Recent Comments

  • arch1

    Some new info on brain wiring. https://scienmag.com/new-study-of-brain-circuits-finds-key-links-to-symptoms-of-depression/ I am convinced that mind is not brain only but is throughout the body,,,including got. It is entirely possible to re-make your mind by perspective,attitude, position including your associations. What you ingest via any sense organs and mouth or IV can effect the mind, wh...

  • $AUPH patents I apologize for butting in before Doc has a chance to respond to your question. In my prior life with a global pharma, I had the responsibility of overseeing company's patent activities on world-wide basis. We always filed follow-up patents continually covering the major claims, with minor modifications but NEWER and more favorable expiration dates. Thus, the patent recycl...

  • Also awaiting news results from the now 15 drills. Robert Friedland - “You're going to need a telescope to see the copper price in 2021!”...

  • Great point. "However" is a term related to concealment and is at least a minor form of deception when looked at from a purely psychiatric point of view. Of course the goal is to conceal until results are posted publically. Although If you ran the email through LIWC engines it gave a lower then average message in confidence....

  • Scarcity and exploration & production are not easily forecast. He may have a winner here, but based on past over-hyped commodities ("peak oil" and uranium and rare earth elements) I am a bit skeptical. The company may bear watching to see what develops over time. Missing out on some possible up-front gains is better than losing big-time if the promises don't pan out later....

  • $CUR, $AXSM no positions at present I completely agree with the above comments, and I feel foolish, as if I should have put two and two together way before. In depression, what is primary in most cases is the thoughts, the moods, the direct conscious experience. And therefore the treatments that work are those that affect consciousness directly. Change of scene, change of companions, a will...

  • Hi Doc, I recently read a twitter exchange regarding $AUPH. The poster said that even if $AUPH is approved for Lupus, the company wont make money since their Intellectual Property for Lupus expires in 2021. Are they correct in regards to the Intellectual property ? Long $AUPH...

  • DR. KSS, I see some coagulation gauze products at drug stores that say they are for external use, but also suggest they can be folded and inserted into anterior nasal cavity. Do you think AC5, if approved for "external use", will be indicated for nose bleeds? That would bring in another first aid use for the product. I understand "external" should be self explanatory, but curious if you think ...

  • $CUR long for the moment. Thanks for the thoughts doc. Wondering if perhaps MDD wasn't the best indication to seek. Is the neuronal/synaptic loss theory more tenuous in depression than in such things as post-stroke, etc? May have a future elsewhere. Depends on where mgmt. takes it....

  • I hesitate to post this again because it is obnoxiously long. But I will repost in case the Doc didn't see it on account of his holiday. I hope you had a rejuvenating time Doc if it was an r/r trip. In a way I wish it was Chris Young who were introducing $MYOK to the Gumshoe. He understands biotech much better than I and details his company introductions intricately and accurately and they are ...

  • Chocolat belgique - my first thought when I saw the rewamped webstite yesterday was "lipstick on a pig" - but thought that was very politically incorrect to post. I dodged the bullet - like Linling would probably have said and got out yesterday - with a nice profit. I too am done with neuro plays - although I think there is a big unmet need. I actually suffered a depression a few years ago - and ...

  • $IVANHOE Copper at 2 year high. Heading back to $3.00. IVN should start to really run from here....

  • $CUR, $AXSM I'm discouraged with the CUR results also. I was really hoping that CUR had a good shot at coming up with a revolutionary way of treating depression. I'm wondering if the announcements emphasis on the positives is spin or if there is actually a hopeful future for NSI-189 in treating depression and other disorders. Even if there is a future for the company I plan to follow Dr. KSS l...

  • $CUR np Besides the 'LingLing-effect' (see point 7 in the excellent article 'Ten Common Biotech Investing Mistakes' by dr KSS for details) and alertness for 'however', I would like to point out another possible warningsign: Prior to the bad news of today the Neuralstem website was updated with emphasis on NSI-189. There was some enthousiasm about that on the boards here perceiving this a sign of ...

  • $ARTH long This is $GREAT news! I celebrated by adding :-)...

  • ## Thats when i got rid of mine. $CUR, almost the same as "Data delayed" as DOC stated before. But did try to get a small position yesterday at the last minute, but with Scottrade and $CUR, have to call and get a broker assist for some reason and was on hold and just hung up. Dumb luck. Took my profit last week. Also was still cautious after the $NTRP. Also as for $AKAO, don't know why down when...

  • Dr. KSS MD PhD

    Slam-dunk approval in all likelihood. There's nothing about it that could evoke rejection. https://www.emergogroup.com/sites/default/files/emergo-fda-510k-data-analysis-2017.pdf...

  • $No. Ticker. Article off Drudge on Ketamine and depression. http://www.independent.co.uk/news/health/ketamine-elderly-patients-severe-depression-effect-benefit-horse-tranquiliser-study-colleen-loo-new-a7859511.html...

  • Three different ways to file 510k filing with FDA with ARTH and they went with traditional. Expected timeline 3 to 6 months depending on how many questions asked and what they ask of ARTH. Do not perceive any problems. They have been talking with FDA for months and have good rapport. I expect partnership is coming next. https://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/HowtoMarketY...

  • Dr. KSS MD PhD

    In defiance of the orthodox theory, I've often wondered the very same thing ajgmorican. The patient who suffers for 15 years on SSRI's but finds self in a new place in life, stops the drugs and regards self as healed. Seen that a lot in practice....

  • $cur np I had high hopes here, I think depressed people need to be around people that are wise and accept things most others find difficulty accepting. So drugs may not be the cure as much as altering ones actual surroundings. The brain finds a way when it's ready to accept so it seems....

  • Dr. KSS MD PhD

    I am deeply discouraged by what's happened. I will not personally do any more neuroscience plays, though am happy to mention them in coverage. Ugly rumors are out....that Johe knew, that there was a data leak yesterday with share dumping. I think it's important to maintain SOME perspective here, however: that NSI-189 DOES cause neural regeneration in the CNS is NOT in question. What has to be figu...

  • Cobalt demand and supply CRU stated earlier in 2017 it "expects 900 T (tonnes) cobalt deficit this year". Investing News state that Macquarie Bank forecasts "a deficit of 885 tonnes is expected next year (2018), with deficits of 3,205 tonnes and 5,340 tonnes expected in 2019 and 2020, respectively." https://seekingalpha.com/article/4090153-cobalt-miners-news-month-july-2017...

  • Bummer about $CUR results. Makes me wonder if there is also an issue with how we tests/screen for depression and other neural indications as well as the drugs themselves. I think you're right on this one Doc. Too much of a black box still for neural plays. Thankful for the guidance here, lightened my position before data read out. Which leads me to $AXSM, does this change your thinking at all ...

  • $SSVFF. Latest drill results continue to expand the potential of this deposit. Vancouver, British Columbia--(Newsfile Corp. - July 25, 2017) - Southern Silver Exploration Corp. (TSXV: SSV) (OTCQB: SSVFF) (FSE: SEG1) ("Southern Silver") reported today that it continues to identify high-grade mineralization from the current core drilling program on the Cerro Las Minitas project, Duran...

  • Awesome, I appreciate the response, eyedoc. Love hearing your insight and rationale. I don't get to play the patient very often in medicine so this has been fun to research and even cooler to have the opportunity to bounce my thoughts off of you. Thank you for your well wishes!...

  • From street contact: (repeat of prior post to avoid it getting lost in shuffle) $MDCO success in TANGO-2 likely to weigh on $AKAO today. Will be a competitor to AKAO’s lead drug – think impact will likely be somewhat muted given docs use combo therapy to treat these CRE infections. This news will provide ammo for the shorts…one point to make for AKAO is MDCO highlighted stat sig for prim...

  • $AKAO Price drop of AKAO is due to $MDCO's new antibiotic whose trial was stopped due to superior activity against all existing therapies in CRE. Please see Zimmy's post this morning - thanks - for details. I exited AKAO at $26 months ago. /Helen...

  • ##No Tick, Hi Mich, its almost addicting when it comes down. I don't know when to stop, just a grab another handful . Hoping turning North soon...Best to all...John...

  • #johncolts54 $CUR hope you watched from the sidelines, me I got my strike 3 on "neuro"...

  • From street contact: $MDCO success in TANGO-2 likely to weigh on $AKAO today. Will be a competitor to AKAO's lead drug - think impact will likely be somewhat muted given docs use combo therapy to treat these CRE infections. This news will provide ammo for the shorts...one point to make for AKAO is MDCO highlighted stat sig for primary endpoint but only said "lower mortality rates" (not quantif...

  • The only downer for me was that product would not be ready for sale for another year. $ARTH long small position...

  • If they submitted a 510K application to the FDA with the same data, then I doubt they are hiding anything. $ARTH long small position...

  • Lesson learned.... Thanks! I looked at the announcement and while they did not meet their primary endpoint, Dr. Fava did say "The company said that the drug did meet a secondary efficacy endpoint of statistical significance on the patient-rated Symptoms of Depression Questionnaire. That secondary endpoint was one of two that the company said it has analyzed so far. "We are encouraged by its emergi...

  • USG has developed a flat pattern between 28-30. Each number represents a breakout or breakdown. Market ALWAYS explode to the flat side but when you have two flat sides--above and below-- it's tricky. There is a slight reason, however, to believe that it will go up. If you notice there was a slight breach at 28 and then a close above that number. (That's a reset.) There is also a mini trend hig...

  • That is a sobering study, IP. S. Pneumonia is a nasty organism. I would hate to be born as one of those rabbits. I use ofloxacin, myself. The moral of the story is to NOT contaminate your wound. Of course, this is a bet on the doctor taking care of his instruments properly, sterilizing the ocular surface with 5% Povidine drops, washing the interface at the end of the procedure, and you keeping you...

  • SoGiAm

    $AXSM long - Axsome Therapeutics Announces AXS-06 (MoSEIC™ Meloxicam and Esomeprazole) Meets Primary Endpoint in Phase 1 Clinical Trial http://globenewswire.com/news-release/2017/07/25/1057586/0/en/Axsome-Therapeutics-Announces-AXS-06-MoSEIC-Meloxicam-and-Esomeprazole-Meets-Primary-Endpoint-in-Phase-1-Clinical-Trial.html Weird, not on their website... Best2ALL...

  • $akao See a tweet by JohnTuckerphd relating to $mdco where he mentions halt of their trial for efficacy is not good news for $akao. Might be that tweet's effect. Tucker knows a thing or two about abx's....

  • $axsm. Long Axsome Therapeutics announces AXS-06 meets primary endpoint in phase 1 clinical trial July 25 (Reuters) - Axsome Therapeutics Inc * Axsome Therapeutics announces AXS-06 (moseic meloxicam and esomeprazole) meets primary endpoint in phase 1 clinical trial * Axsome Therapeutics Inc - ‍primary endpoint met with 9 times faster time to maximum plasma concentration tmax of melox...

  • @ Fred - that's just it (what's not to like?). Looking at their Q1 2017 Report, they even produced revenue (so far). Sooo, why is the stock so cheap?...

  • trading was halted premarket....

  • $AKAO np. Good news and price drops. Seriously!!!...

  • Something to the effect that stocks fall whenever a press release contains the word "however." That's, I think, why she exited CUR before now....

  • Here's the link to her comment: https://www.stockgumshoe.com/2017/06/oncotutorial/comment-page-7/#comment-4942413 The quote: "Hi Marianne, thanks for your efforts in contacting IR of CUR. The reply looks generally benign except for the last sentence starting with “However…” There have been ample discussions on Twitter that anytime this word was found in a PR, the results were frequen...

  • Mossysprog Helen had mentioned the use of the word "however" was interestingly placed in $cur response when asked if the results were being delayed a week ago. Ive also been wanting to ask would the 10000 shares bought by an $abio insider be considered as the "lingling effect", the example in the 10 Biotech Mistakes said 5000 shares right before results is usually a bad sign???...

  • Thought we'd see bigger volume on the ARTH news. Just glad it wasn't bad news. Long ARTH....

  • $CUR long fp - The good Dr. suggested we might want to take profit. I guess it is like when my wife says "You never listen to me" :(...

  • In the grand scheme of things the accelerated 510k filing in US much more important than EMA submission. EMA submission will come in due time, meanwhile focus will be on huge market in US with AC5. Cheers,Glenn...

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