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“Three Biotechs Beating the House”

Finishing up our look at Louis Navellier's Emerging Growth teaser picks

The following was originally published, along with this companion article, in late February. Louis Navellier is again pushing exactly the same ad teasing the same three biotech stocks, over the last three months two of them are down and one of them has popped up by about 30% (it was, of course, the one that least impressed me that did the best). We reprint this here for those who are asking about the teaser pitch, the companies are still similar with little in the way of dramatic news in the interim, but the following article has not been updated or revised in any way since February 26.

******from 2/26/14********

Yesterday I promised to follow up on Louis Navellier’s biotech picks — these are three stocks teased and hinted at in the latest promo for his Emerging Growth newsletter.

The first one, covered yesterday, was a Chinese vaccine company called Sinovac (SVA) — no stranger to the world of Gumshoe, but not a favorite of mine personally, despite their pretty solid and presumably recurring business in some core vaccines in their home country (influenza and Hepatitis A and B, mostly).

So what else is he pitching? Well, I already let the cat out of the bag on number two, but we’ll run through the clues anyway …

“Our #2 Biotech Winner of 2014 is a royalty powerhouse with one of the largest and most diversified portfolios in the industry.

“Last year was its ‘break-out’ year—two approvals, 6 Phase III results filed, two orphan designations and a whopping 20 net assets added to its portfolio.

“And 2014 is going to be even better—with revenue generating drugs expected to double over the next year.

“Not to mention that this company has a whopping $700 million in milestone payments from existing deals… Plus, another $800 million in projected R&D investment by its partners over the next year… With more than 80 clinical trials to be run in 2014… And royalties for its current assets are projected to exceed $2.2 billion over the next three years.

“That’s a whole lot of big numbers for an overlooked stock that still trades at just a $1.3 billion market cap.

“This may be our next 600%+ winner, just like Santarus last year, particularly since it keeps taking shots on goal.

“Its latest drug is a novel new diabetes treatment with blockbuster potential. Before that, curing hot flashes. Before that, a treatment that cleans the toxic ‘plaque’ that causes Alzheimer’s disease….

“So with the company’s revenue doubling and its stunning earnings numbers, I expect it will keep racking up the regulatory approvals and handing us smooth and steady gains through the year ahead.”

So that one, which may have come quickly to mind for Gumshoe readers if only because Navellier borrowed the company’s “shots on goal” phrasing, is Ligand Pharmaceuticals (LGND). That was our “Idea of the Month” for the Irregulars back in June, and it does indeed seem like the kind of stock newsletters would love to tease — it’s shareholder-friendly, with big margins and few employees, it uses other peoples money to advance its own business, and it has catalysts for potential growth.

That doesn’t make them stand out among royalty companies — that’s the basic idea of a royalty business, after all — but there aren’t really any other strong, decent-sized pharmaceutical royalty companies that are publicly traded (at least, not that I’m aware of). Ligand has built a large portfolio of compounds that are partnered with big pharma and biotech companies for development, and those compounds require no further investment from Ligand. If they get through to approval after lengthy and expensive clinical trials (yes, LGND partners really are expected to spend $800 million advancing those compounds this year, in 80 different clinical trials), then Ligand gets a royalty on the sales of that product. The royalties vary greatly, some are down around 1%, a few are much higher — including Ligand’s most valuable product, Promacta, which is marketed by GlaxoSmithKline (GSK is also actively trying to expand the label for Promacta, with several clinical trials). The second most valuable product, Kyprolis, a cancer drug marketed by Amgen now, is also the fastest growing — but has a lower royalty rate.

The reliance on Promacta is slowly declining, though it will be the biggest revenue chunk for a while, and the “shots on goal” strategy at Ligand reflects the fact that they really consider themselves a financial company — they put some R&D investment in, including on their diabetes drug that Navellier mentions, but their goal is to partner off everything and make new deals to bring in royalties or other programs that they can use to build their partnered drug portfolio and their future royalty stream. They get these new deals largely from acquisition, including the big deal to acquire Selexis last year and expand into biologics, but they also build them by using their targeting and delivery materials to buy a piece of a drug — their biggest is Captisol, which is a drug delivery platform for intravenous drugs, and their sales of Captisol are growing substantially but also creating future royalties (since they often acquire a small royalty for the use of Captisol with an existing or developing drug, or develop a drug by simply combining it with Captisol).

At this point, Ligand’s big drivers are Promacta and Kyprolis, with a half-dozen other small products producing royalties as well, and the near-term hope is that Duavee from Pfizer will generate substantial royalties after launch this month (that’s a controversial menopause drug that has been in development for more than a decade), or that Merck’s work with the partnered MRK-8931 BACE inhibitor for Alzheimer’s will show promising results in current trials, or that Ligand will be able to soon partner their largest current drug program, their Type 2 Diabetes drug that’s expected to have some results this Summer. But there are dozens more that could provide future revenue, their “shots on goal” strategy is to not invest heavily in any of them but to advance many potential products and let the odds work for them — they say that if the historical averages for success rates in drug approval at each stage apply to their portfolio they would have about 20 revenue-generating assets by 2020.

What I really like about Ligand is that their cash expenses don’t change much — which means that their projected increases in revenue hit the bottom line very nicely, they project that they’ll have non-GAAP earnings per share of well over $3. (That excludes stock-based compensation, particularly, as well as some possible incentives from past deals (CVRs) that would presumably be largely stock-based). It’s more likely to be a little less than $1.50 this year, so the stock is NOT cheap at $70+, but it is growing rapidly. Personally, I would have a hard time even nibbling at $75 but you might be able to talk me into it if I didn’t own the stock … my last buy was a small reinvestment of covered call sales in the mid-$60s a while back, and LGND has grown up to become one of my top-five holdings on the strength of its huge move in the last six months. I got nervous about my LGND holdings for a while last fall, given their incredibly rapid rise, but as I’ve continued to follow their progress I’ve become more comfortable with the relatively lofty valuation.

I’d still be happy to add a bit more on dips, but I don’t want to jump up and down and yell that people should buy it at any price — biotech has been on a tear, this is a company that had a huge breakout year with everything working perfectly in 2013, and there seems a strong likelihood that we’ll see negative analyst comments or disappointments at some point in the next few months that provide a cheaper buy price, or a failure or setback for one of their larger products or one of their “high potential” pipeline “shots on goal”. That said, analysts could give up and pile back on, too — the average price target for the shares is down in the $60 neighborhood, and they could continue to do very appealing acquisitions now that they have a nice strong stock as a currency — I think the biggest likely risk to Ligand’s stock, absent surprising bad news about Kyprolis or Promacta or Captisol, is probably a rerating of the biotech space in general and a loss of investor enthusiasm for the sector, so I’ll hope for that and look to buy some more when it happens.

Wishy washy enough for you? Let’s move on and try to identify Navellier’s third pick:

“Finally, our #3 Biotech Winner of 2014 has a unique claim to fame—it’s immune from scrutiny by the Food and Drug Administration.

“This company solves the manufacturing challenges as drug-making shifts—from traditional pharmaceutical synthesis via everyday chemicals to bio-compounds that are purified from living organisms like bacteria.

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“I’m especially excited about its ‘Factory of the Future’ rollout as biomanufacturing moves from permanent glass-and-steel production facilities to ones that can use disposable products that drastically reduce the time needed for purification, ups efficiency and lowers cost.

“We’re already enjoying 100%+ gains in this stock, and there’s plenty more upside to go as the company continues to blow out earnings and raise its forward guidance.”

Well, this is not a 100% match for the Thinkolator — not enough clues of the precise or calculable variety — but after running the clues through our favorite machine I have a high degree of certainty that he’s teasing Repligen (RGEN).

RGEN is a top-rated stock in Navellier’s PortfolioGrader system, though the area of future growth and earnings momentum is the one where the grade probably gets depressed a bit. The stock is not seeing analyst upgrades or increases in analyst estimates, despite the fact that it has indeed beat analyst estimates for the past two quarters, and that’s largely because their “Factory of the Future” business is not going to grow fast enough to replace the high-margin royalties that they received in a deal that ended on December 31 (that’s the royalty on Orencia from Bristol Myers, which ended last year and supplied a big chunk of RGEN’s revenue). Given even steady growth in the rest of their business, which is mostly bioprocessing equipment and materials sales (including Protein A, used in manufacturing monoclonal antibody drugs, and the OPUS disposable plastic column — more on that in a moment), they’ll probably have earnings per share in 2014 that are about half of what they were in 2013… though that’s all very much in the price, one would expect, since this is not a surprise event and investors have been actively prepared for it by the company for several quarters now, and then they’re expected to grow the bioprocessing business organically from that new, lower base.

Any qualm about this being the match comes from the notion that the company is continuing to “blow out earnings and raise its forward guidance.” Technically that’s true, I guess, at least until the end of next week when their fourth quarter will be released (don’t know if they’ll “blow out” that number or not … and they have been raising their forward guidance over the last couple of quarters, but the increases in forward guidance have been tepid — generally things like narrowing the expected revenue from $20-24 million to $22-24 million (that’s just an example, not their actual numbers). Increasing guidance is a good thing, sure, but it’s not on a scale that makes you think the company is experiencing fabulous and surprising earnings momentum.

This looks to me like a solid small growth stock, on the back of their expanding OPUS and decent growth in the bioprocessing and Protein A business, and they’ve partnered a couple of small drugs off now and made a decent-sounding deal with Pfizer for another so that they can really focus on growing that part of the equipment business, a transition that’s been underway for them for about three years. This is a $500 million company that’s about to have earnings cut in half, which would normally scare off a growth investor, but if you look forward it’s not all that bad — reset your expectations for earnings growth of perhaps 15%, with potential boosts coming from future milestones if the drugs they sold off ever amount to anything, and perhaps from acquiring more capacity or potential with acquisitions that could expand their bioprocessing business (that’s what most investors think they’ll do with the $70 million or so in cash they have on hand, partly because it was a series of acquisitions that built and consolidated the core business they now rely on).

The OPUS is that “factory of the future” stuff, a tool for making biotech drugs more flexibly and cheaply than current (glass and steel) manufacturing technology — here’s how they describe it:

“Repligen’s pre-packed disposable column technology enables user specified inputs tailored to specific applications. This means end-users are easily able to replace self-packed glass columns with OPUS pre-packed columns for disposable manufacturing processes….

“Combined with the largest range of internal diameters available on the market, OPUS is the only pre-packed column platform which can accommodate the chromatography needs of a disposable manufacturing facility.”

Gosh, don’t you just want to run out and buy one? Well, from what I’ve read so far they do seem to be getting customers — from something like this you’d expect growth to come first from experiments by big manufacturers or by emerging products like a new biotech drug in clinical trials, not from large-volume existing drugs where they wouldn’t want to mess around with the manufacturing process… so presumably there won’t be massive spikes in earnings or overwhelming order volatility. But there are new drugs being developed every day, and perhaps if you develop a drug using this equipment you’ll want to stick with it and use the same equipment when you scale up … presumably the risk of switching would counteract any cost savings of switching to competitors, which is both a challenge for them as they build the business and a competitive advantage once they have some business.

I know almost nothing about biotech manufacturing, so I’ll leave it to you to go forth, researchify some on Repligen, and let us know what you think. From here, it looks like a small and fairly expensive growth stock, probably pretty predictable and with very good margins and a solid record of cost cutting and increasing focus and efficiency in recent years … but it’s trading at about 75 times the expected earnings for 2014, so if you want to buy the stock you’ll have to get yourself comfortable with whatever you think their earnings growth rate might be. I’d have to guess that the shares will likely get cheaper as the “new” Repligen is reflected in their earnings this year (without Orencia royalties), but they might not — particularly if they make good use of their cash to expand quickly or make an acquisition that investors love.

Good luck to you, and please share your thoughts on either Ligand or Repligen, or whatever else seems relevant, with a comment below. And now, I need to take a break from biotech for a couple days and write about something else — off to prospect in the email mines and see what I can find that might be of interest to share with you tomorrow.

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Alan Harris
Guest
Alan Harris
February 26, 2014 1:04 pm

Hows about thinkolating the GS advert: Boston Biotech Tests New Drug That Kills Cancer Cells From Within 🙂

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Elliot Sedlecky
Guest
Elliot Sedlecky
February 26, 2014 2:05 pm

I’ve been following RGEN since I read a SA article on it toward the end of last year. Unfortunately, I decided not to buy because of the expected earnings fall and I’ve watched it nearly double in price 🙁

jenngld
Member
jenngld
February 27, 2014 1:51 am

Good analysis.
Companies have excellent upward potential this year. “Stocks can produce huge returns for investors in 2014”. NeoStem (NBS) – Developing a stem cell industry. MannKind Corporation (MNKD) All or nothing with its diabetes drug. ORAMED – Oral Insulin drug Oramed stock has had a stellar year ending with a bang.

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komal1234
Member
komal1234
February 27, 2014 2:22 am

Here are some of the top biotech names to buy and the stocks with the highest upside for 2014.
1. Acorda Therapeutics Inc. (ACOR)
2. Amgen Inc. (AMGN)

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DoctorJack
Guest
February 27, 2014 6:22 pm

I see that both the author and at least one of the respondents have a familiar problem. That is, when you see/hear a a recommendation, you face the quandry of “should I buy it or not” and if you do buy it, how to you save your a$$ if it tanks. I went through the same thing in March of 2000 as the market were crashing. When the smoke & explosion had cleared several years late, I was left with a fragmented portfolio that was a mere shadow of it’s former self. Just as I was about to give up, some friends whom I had met online. You see for almost 10 years I had used Technical Analysis to direct my investments. And I DID make ton – in the bull market. But a friend volunteered to help me learn to understand the market the way he did. And in teaching me that, he showed me not only the way to pick stocks that had a strong likelihood of going UP, but also when to tighten a stop loss order or even just sell outright. Elliott, who commented above would have been able to “see” that RPGN was a buy ans a hold as it was doubling. And the publisher would have been able to see through the clouds with LGND:

“Personally, I would have a hard time even nibbling at $75 but you might be able to talk me into it if I didn’t own the stock … my last buy was a small reinvestment of covered call sales in the mid-$60s a while back, and LGND has grown up to become one of my top-five holdings on the strength of its huge move in the last six months. I got nervous about my LGND holdings for a while last fall, given their incredibly rapid rise, but as I’ve continued to follow their progress I’ve become more comfortable with the relatively lofty valuation”.

Some hints:
1- the charts you see in books & on the web don’t tell you enough.
2- looking at a chart in 1 time frame is worthless. You need to look at 3 time frames… one SHORTER than your “TARGET time frame and another LONGER than your target time frame. ALL 3 HAVE TO AGREE!
3- don’t memorize price or indicator patterns. You have to learn WHAT an indicator is TELLING you, and by using several or multiple indicators to review many, many stocks, the “patterns” will begin to make sense. It’s all about recognizing buying & selling, accumulation & distribution, money flowing into and out of a stock and support and resistance. And volume is the fuel that feed the fire. Here is a thought to start you off. Think of this traffic signal analogy: price going up & Volume going up = green light – buy. Price going down & volume going up = red light – get out. And price going in either direction with no volume pattern to discern = indeterminate. And remember, volume has 2 characteristics… high volume days (height of bars) OR grouped volume days. i.e. multiple days of average volume in repetition of a similar color – green for buying or red for selling. Train you eye to recognize these volume patterns and their relationship to price as it moves up and down. You will be off to a start when you do.
Then learn to recognize trends, how to use price channels, Bollinger Bands and Stochastics. Put them together and see how market moves become less mysterious.

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Alan Harris
Guest
Alan Harris
February 27, 2014 7:19 pm
Reply to  DoctorJack

Gobbldygook. But I have the suspicion youve found a truth. Can you pls give a specific example so i (we) can follow. Someone did you the favour didnt they? Bread on the water always comes back.

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M P
Guest
M P
June 17, 2014 6:39 pm
Reply to  DoctorJack

Doctor Jack,
Thanks for this message.
I went through the same thing in 2000 -2002 with a few investment in stocks and at the time did not have the knowledge to know when to sell or how to save my $$ and saw my $$ tank. Lost much. I thought I learned my lesson and recently did same with another stock . See my question to Group below.. I need some wins 🙂

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DoctorJack
Guest
February 27, 2014 9:11 pm

OK. I will give a few pointers here in follow-up comments./DJ

DoctorJack
Guest
February 27, 2014 10:45 pm

For starters, check out this web site: http://www.investopedia.com
That is a reliable site to look up information on both fundamental and technical questions regarding investing. Sign up for some of their free emails – there are a number of different topics. It is a good site to learn from.
Now learn all you can from them about the following: “Bollinger bands” “Stochastic indicators” (including this site- ) and this one too: “elder’s triple screen”. Additional articles to review = “MACD And Stochastic: A Double-Cross Strategy”, “Stochastic Crossovers “, and “Two indicators are better than one”. Don’t memorize, just try to understand the concepts. Remember, NO indicator is cast in stone, Combinations of Indicators can be additive AND can be confusing. Plus any indicator can be “customized” i.e their parameters can be altered if needed. This will help for what is to come./DJ

johnmca99
Member
johnmca99
March 3, 2014 6:57 am

Hi all
They are absolutely brilliant analyses. I have only discovered this site recently after I googled something to contra Motley Fool and Gumshoe came up and I must say it is relaxed and informative group
Your indicators of when to buy or not … the “green” shows me that BIR.IR is a stock worth watching Ball park > 40M shares are traded each day and it is a case of two steps forward one step back. I believe hedge funds are the primary reason for this but the candle shows an upward trend I purchased recently and I am up 10% c. Ireland is on the on mend and this bank would be considered the strongest of the banks here They are down today but they had a huge rally just before the close last Friday. Keep an eye out for them they are cheap and cheerful at the moment
Regards
John

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Alan Harris
Guest
Alan Harris
March 3, 2014 7:55 am
Reply to  johnmca99

If you think this thread is good, you should spend a WHOLE $49 becomming an Irregular…..best investment I ever made. Ive added 3 naughts.

Exactly which ‘green’ indicator do you refer to?

Slick Rick
Guest
Slick Rick
June 12, 2014 6:09 pm
Reply to  Alan Harris

I joined The Irregular service for $49 . The money was charged to my credit card , and yet I cannot access the premium or irregular service. I had sent an inquiry to Stockgumshoe at their contact address……about 4 times with absolutely NO response.
Service is the worst I had ever encountered. Perhaps I should have left well enough alone and remained a free member ?

Alan Harris
Guest
Alan Harris
June 12, 2014 6:13 pm
Reply to  Slick Rick

Worry not. GS is a great place. Sorry somethings gone wrong, but chill. Travis WILL sort. Im not a paid employee, but Im a happy bunny. Im sure you will be too. $49 will seem like chaff for whats on offer here.

Alan Harris
Guest
Alan Harris
June 12, 2014 6:15 pm
Reply to  Slick Rick

PS….Best to post at top of thread or things get lost down under.

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Lynn Clark, Stock Gumshoe
June 12, 2014 10:56 pm
Reply to  Slick Rick

We have found the problem and corrected it. I apologize for the trouble. I’ve sent you an email with all the details. Thanks for your patience.

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baygreen
June 16, 2014 5:38 am
Reply to  Slick Rick

NEVER HAD A PROBLEM SOMETHING WRONG BUT COMPLAINING NOT HELPING IF YOU FOLLOW IT ENOUGH GET ONE OF THE IRREGULARS TO HELP I TRAVEL TO MUCH OR I WOULD YOU WILL BE HAPPY IN LONG RUN YOU WILL GET IT. hE IS AS FAIR AS THEY COME. SORRY FOR YOUR PROBLEMS BUT GET A REGULR IRREGULAR AND YOU WILL GET HELP I WOULD BE SURPRISED IF YOU DON’T GET IT DONE THERE ARE SOME GREAT IRREGULARS. GOOD LUCK

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Frenchy
Frenchy
March 3, 2014 1:36 pm

Hello, simply getting on the thread for now.

David B
Guest
March 18, 2014 1:46 am
Reply to  Frenchy

Bienvenue ici Frenchy. SVA a une vaccine avec promis.
My French is rusty, but I have invested recently in SVA due to DR. KSS analysis that it has a very promising new vaccine against a particularly nasty form of Foot and Mouth disease that is prevalent in Asia. He sees it as a winner for a company which was growing even without this vaccine.

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rblade
Member
rblade
March 8, 2014 4:14 pm

Lewis has owned RGEN, LGND before not sure about SVA so for them to show up on his emerging growth when RGEN was a Blue Chip pick, why did he sell?

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Frenchy
Frenchy
March 18, 2014 5:38 am

Merci David,

I remember your bringing up Sinovac on another thread with Dr KSS. Thanks for the reminder.

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David B
Guest
March 21, 2014 11:55 pm
Reply to  Frenchy

SVA had a great week Frenchy as it outperformed on both revenue and earnings. It’s doing this even without any revenue yet from its most promising new vaccine against HFM disease which is particularly prevalent and nasty in Asia so this should be a big winner for Sinovac. For investors who want more safety than most small biotechs offer, I think SVA is a great investment as it’s already bringing in strong and growing revenue. There should not be any PP dilutions necessary. The HFM vaccine looks very likely to be approved–great New England Journal of Medicine article showing superb results. The upside is solid and strong (not nearly as high an upside and Benitec but also much less risk). I’m liking SVA more and more all the time and may add to my position on a dip.

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Frenchy
Frenchy
March 22, 2014 6:19 am

I’ve noticed and regret now having bought any. I ended up buying ELTP instead… I got a few dollars to spare so maybe I’ll wait for a dip as well. It is on my watchlist

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c193
c193
June 12, 2014 12:24 pm

DoctorJack, what you describe sounds similar to ThinkorSwim, a trading platform that is (from what I can gather) free with a TD Ameritrade account. I am thinking about starting an account there and playing a bit. I actually took a beginner’s class in ThinkorSwim several years ago.

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DocctorJack
Guest
DocctorJack
June 12, 2014 2:02 pm
Reply to  c193

I am familiar with TOS. And what I hear is that it is a great program. I do my investing thought Fidelity, not TDAmeritrade simply b/c I have been with them for about 35 years. The market software I use (since about 1990) is Telechart from Worden Brothers Inc. I started back in the DOS days and their new software is fantastic. The most important thing to remember about trading is that you have to understand what the indicators are telling you about the market and the stock you are looking at. You don’t just follow blips & lines. You have to recognize that the market is like a living breathing beast that can be placid on one hand and eat you alive on the other. You indicators are your window into what is going on in the movement of a stock’s price. I would beginners read, read and read first (both fundamental and technical material) and learn to use both. You find the best stocks fundamentally and trade them technically. That is exactly what I do. I use IBD and Zacks for my fundamental screening and trade those with great fundamentals. A novice should NEVER trade without a long learning curve with PAPER TRADING ONLY! When you are sure you can do that successfully, only then, do you commit your money.

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DocctorJack
Guest
DocctorJack
June 12, 2014 2:19 pm

Added info…when I see “recommendations” I go right to my charts on that company. Sometimes I see that buying that stock would be a loser, it is overbought and ready to go down! Sometimes, the chart is indifferent, and I don’ buy “indifferent” stocks. But I can also see a great unfolding pattern of an oversold situation in a good company, that if you know how to use charts, is just begging to be bought. They are the ones that I make my best profits from. And, as long as they are working for me – I hold them. But, I have no qualms about selling a holding as it corrects and buying it back when it bottoms. ALL my trading is in tax deferred accounts like IRA’s etc. Taxable accounts are managed for the most tax efficient gains. I always assume that there are traders who are smarter than I, so I look for signs of accumulation before I buy a stock and distribution before I sell one. “They” say it can’t be done but that is a load of crap. When doe correctly , profits always far outrun any losses which should be kept to a minimum..

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Dr. Shizz
June 18, 2014 1:31 am
Reply to  DocctorJack

Well said, enjoyed the read.

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c193
c193
June 12, 2014 5:01 pm

Good points DocctorJack!

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rjcrot84
rjcrot84
June 12, 2014 8:49 pm

I’ve held LGND several time and made money every time. A great stock that has actually been promoted on this website, not just by Navellier. Need to watch your entry point on LGND; however, it’s probably a pretty good long-term bet. Also had SVA for several months but found it to be dead money, in fact sold it at a loss.

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DoctorJack
Guest
June 13, 2014 12:25 am
Reply to  rjcrot84

Robert- you are correct on SVA. Dead money for months now and will likely go lower in the near future. LGND on the other hand is a buy for intermediate term upside. With the mkt being sloppy here it might trade down a few more dollars. There is support around 60. An entry near there would be a good opportunity. It closed at 66.61 today. I would wait to get it lower. That opportunity should be here soon. Upside target price ~ $80/sh

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Elliot
June 13, 2014 7:31 am
Reply to  DoctorJack

What’s so special about LGND? The chart looks nice, but it looks fundamentally overpriced

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Elliot
June 13, 2014 8:19 am

Thanks, Travis

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DoctorJack
Guest
June 13, 2014 11:49 am

Ah, the eternal question, what statistics to believe and what to ignore? That is why most investors consider the stock market to be just like a Las Vegas casino! It’s like we’re elephant hunting with a bee bee gun. How to get our target without getting trampled. I don’t have all the answers either, except to say play your hand safely. See my comment below.

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Dr. KSS, MD, PhD
June 13, 2014 11:12 am

I would encourage Irregulars not to tie their fortunes to Navellier’s recommended Repligen. This stock has grown literally exponentially, as a smooth proxy or index of biotech fortunes. The pesky force called gravity is going to intervene in share price.

It is impossible to successfully vaccinate against Staphylococcus aureus. Why? Because vaccine causing the production of antibody, and antibody does not touch Staph. That is because by natural selection, Staph has evolved 2 proteins, A and G, that antibody of the IgG class sticks to fervently. This sumps, diverts, wicks away the antibody so that it cannot attack the germ itself. And is a wonderful tool for purifying IgG (nearly all pharmaceutical monoclonals are IgG, not IgA, IgM, IgD or IgE). Prior to Repligen, protein A was made by growing liters of Staph cultures, killing the bacteria and teasing the protein out of the bacterial crud. Repligen cloned and sequenced the protein A gene and placed it into yeast to make large quantities of recombinant clean protein A. But Repligen’s patent on this recently expired, which means that frankly better biotech support companies such as Thermo Fisher and GE Healthcare can come along now and do the same thing.

People have misconceptions about Big Pharma…..that each company owns plants that chug out drugs 2 shifts a day. Not true. Mostly there are non-denominational cGMP factories out there now, and they have dance cards on which Big Pharma books time….say one month a year for the making of that year’s run of Irregularimab….done using a one-time use throwaway protein A Sepharose column from Repligen that costs 50k. They can charge this confiscatory price because of the environment. Company X does not want to use the column Company Y used a month ago….it might be contaminated with company Y’s cooties. But monolithic Big Pharma does still often run its own secretive factories year round, and in those they use truly industrial chromatographic columns, the size of a cannon, that can be mothballed in azide to kill bacteria, eluted occasionally, and function on a permanent basis. With a wave of M&A activity, there will be consolidation and less need for throwaway protein A columns. And my suspicion is that Repligen’s columns cannot be reused…that they are made of cheap enough resins that they crump with recycling.

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DoctorJack
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June 13, 2014 11:33 am

Great point Dr. KSS, MD, PhD!

My 10 cent corollary of that would be when a stock like RGEN (which BTW, I have a position in) rises exponentially, you should be fearful not jubilant. It can fall fast and just as hard. The cautious would be SELLING into this exponential rise and banking profits. At the very minimum, use a trailing stop! The mortal sin of investing is loosing capital and hard won gains.

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who noze
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who noze
June 13, 2014 4:36 pm

i was an early investor so earley that i took a revessplit

M P
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M P
June 17, 2014 6:49 pm

What about MRI Interventions (MRIC) ?
(MRIC), a commercial stage medical technology company focused on creating innovative platforms for performing the next generation of minimally invasive surgical procedures in the brain and heart. It opened with great promise and to me seemed to be sound in technology and medical need. I invested. It has not taken off and been “stuck at stable” UNTIL recently…where it has taken a real drop (not sure why?) However, it seems that this technology, ClearPoint(R) Neuro Intervention System should take off and they have shown it safe and being used by top Neuro experts and Medical Centers. What is keeping it back? I am invested.
The ClearPoint system’s role is in enabling real-time MR-guided neurosurgical procedures .
Anyone have a comment? Thanks.

DrKSSMDPhD
June 17, 2014 7:42 pm
Reply to  M P

You’re asking why it is going down. I wonder if a much better question would be: what is to keep it from going down? Nothing so far as I can see. This company strikes me as barely relevant, and one going to extraordinary lengths to whip up interest in a cap-ex likely to find no takers. I don’t see its methods as an improvement on existing ones. For this company to be trying to do this in this field, against the likes of GE, Siemens and Philips? Gee, that is a lot like me getting a BB gun and a rowboat and heading off for the Mediterranean ‘cuz I want to make a difference in the ISIS conflagration. Cut your losses and get out of this stray-dog stock. I watched its “instructional video,” and the only instructions I glean from it are a feeling that no one should be in this stock. This is a Memphis shuck-n-jive, not a real investment.

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M P
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M P
June 17, 2014 10:47 pm
Reply to  DrKSSMDPhD

Dr. KSS, MD, PhD,
Thank you for your review and assessment. I really appreciate it.

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