AOZ#Alzheimer’s_disease , #Obesity , #Zika –
The #Numbers , #$s , #Mystery , #KASH ; #Past #present & #future
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#zika – Team Shows How Zika Crosses Placental Barrier to Cause Birth Defects http://www.genengnews.com/gen-news-highlights/team-shows-how-zika-crosses-placental-barrier-to-cause-birth-defects/81253835
Lundbeck gives up on Alzheimer’s drug, rival to Axovant pill http://in.reuters.com/article/us-health-alzheimers-lundbeck-idINKBN15N16R
#Zika – Mosquitoes swat back via resistance to CRISPR gene drive
http://www.ipscell.com/2017/02/mosquitoes-swat-back-via-resistance-crispr-gene-drive/
Hi Ben! Just found this topic. Nothing of my own to contribute here, at least not yet. Wow this field is huge, isn’t it? Kinda makes my brain hurt reading all the bio stuff, but in a good way.
$TDSGF – 3D Signaturesโ TeloViewโข Software Identifies and Stages Patients With Alzheimerโs Disease From a Cheek Swab http://globenewswire.com/news-release/2017/03/21/942602/0/en/3D-Signatures-TeloView-Software-Identifies-and-Stages-Patients-With-Alzheimer-s-Disease-From-a-Cheek-Swab.html
Alzheimerโs: Learning From a Legacy of Bitter Setbacks
https://endpts.com/special/alzheimers-2017/
Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awx052
The Alzheimer’s Treatment That Repairs Brain Cells In Mice Just Got More Promising http://thelightmedia.com/posts/58484-the-alzheimers-treatment-that-repairs-brain-cells-in-mice-just-got-more-promising
How hibernating animals are helping doctors treat diabetes and Alzheimer’s http://www.wired.co.uk/article/animals-hibernating-treat-diabetes-alzheimers
First Alzheimerโs Patient Treated with Focused Ultrasound to Open Blood-Brain Barrier https://www.medgadget.com/2017/05/first-alzheimers-patient-treated-focused-ultrasound-open-blood-brain-barrier.html
#Alzheimer’s Prevention – interesting new findings published in Medscape
“Olive Oil Key Ingredient in Alzheimer’s Prevention?”
June 27, 2017
Extra-virgin olive oil (EVOO) appears to protect memory and learning ability and reduces the formation of beta amyloid (Aฮฒ) plaques and neurofibrillary tangles in the brain โ the classic hallmarks of Alzheimer’s disease (AD) โ new animal research shows.
The study, conducted by investigators at Temple University in Philadelphia, Pennsylvania, suggests that it is the olive oil component of the Mediterranean diet that likely promotes healthy brain aging.
“Our study is the first demonstration that EVOO can beneficially affect memory, amyloid plaques, and tau pathology, the hallmark lesions in the brain of Alzheimer’s patients,” lead researcher Domenico Pratico, MD, professor of pharmacology and microbiology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, told Medscape Medical News.
“And results are important enough to absolutely encourage people to consume greater amounts of EVOO. Given that it’s been consumed for at least 2000 years, I do not anticipate any side effects,” he added.
The study was published online June 21 in the Annals of Clinical and Translational Neurology.
“Exciting Finding”
For the study, the investigators tested the potentially beneficial effects of EVOO on triple transgenic mice. These mice are specifically bred to develop key pathologic features of AD, including amyloid plaques and neurofibrillary tangles.
The animals were divided into two groups. One group received EVOO-enriched chow, and the other received regular chow without EVOO.
The olive oil was introduced into the diet when the mice were 6 months of age, before they began to develop symptoms of AD.
At 6 months, all animals were tested for their behavioral performance on a series of tests in order to establish baseline competency.
“Overall, we did not observe any statistically significant difference between the two groups of mice during the study, except for the 10 month time-point when the treated mice had a higher body weight than untreated ones,” the investigators report.
The mice were subjected to the same behavioral tests at both 9 and 12 months of age, after which they were euthanized and their brains were examined for the presence of key pathologic features of AD.
The researchers confirmed that mice fed the EVOO-enriched diet performed significantly better at both 9 and 12 months on tests designed to assess working memory, spatial memory, and learning abilities compared with mice fed regular chow.[…]
http://www.medscape.com/viewarticle/882149?nlid=116152_4503&src=wnl_dne_170628_mscpedit&uac=24471DV&impID=1378355&faf=1
Thank you, Helen, for sharing.
https://www.stockgumshoe.com/2017/06/oncotutorial/comment-page-1/#comment-4940136
#Alzheimer’s – Stress may be linked to Alzheimer’s. Other lifestyle factors that may reduce likelihood are exercise, sleep, weight control, reading, diet. #Stress and Alzheimer’s: More Evidence Strengthens the Link #TipsforCaregivers #potentialdisease … https://twitter.com/BirdBrayn/status/881037210157432835
Alzheimers emerging concepts;
https://www.alz.org/aaic/program/emerging-concepts.asp
https://healthminute.org/2017/07/alzheimers-disease-could-be-treated-with-gene-therapy/ shared by Arch1:
https://www.stockgumshoe.com/2017/06/oncotutorial/comment-page-3/#comment-4940920 Thanks Frank!
Scientists uncover the structure of tau filaments from Alzheimer’s disease https://medicalxpress.com/news/2017-07-atomic-protein-tangles-alzheimer-disease.html#jCp
Cryo-EM structures of tau filaments from Alzheimerโs disease
https://www.nature.com/nature/journal/vaop/ncurrent/full/nature23002.html
#AD – Human Blood May Offer Fresh Approach for Dementia Treatment
http://www.medscape.com/viewarticle/883474?
#Alzheimers – Brain scan study adds to evidence that lower brain serotonin levels are linked to dementia https://medicalxpress.com/news/2017-08-brain-scan-evidence-serotonin-linked.html
#alzheimers Really interesting. Father-in-law has early dementia (mother-in-law has advanced dementia. Both were heavy drinkers, had high fat diets, smoked a lot early in life. Wondering which of those factors, or all, contributed). He’s depressed and craves ice cream/sugar, which are also signs of low serotonin levels. Now if they can determine cause of lower serotonin levels many could be helped before they develop dementia.
Simulation Shows The High Cost Of Dementia, Especially For Families
https://scienmag.com/simulation-shows-the-high-cost-of-dementia-especially-for-families/
#ZIKA – Dr. KSS MD PhD
Two years ago, the media made extreme heavy weather about the coming of Zika and the birth defect risk it imposed. Zika was coming to the America, north, south and central. It came alright, did some harm, but we were told it would be a permanent fixture of life here. Not true, that turns out: only 1 case reported in continentl US, in south Texas.
http://www.sciencemag.org/news/2017/08/zika-has-all-disappeared-americas-why
https://www.stockgumshoe.com/2017/06/oncotutorial/comment-page-19/#comment-4946726
#Obesity – Energy dense foods may increase cancer risk regardless of obesity status – Scienmag #EnergyDense foods
https://scienmag.com/energy-dense-foods-may-increase-cancer-risk-regardless-of-obesity-status/
#Alzheimers _Hypothesis โSerum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimerโs Disease.โ Sternberg Z, et al. Aging Dis. 2017… https://www.stockgumshoe.com/2017/06/oncotutorial/comment-page-19/#comment-4946921 Thank you Helen!
$Alzheimer’s – Alzheimer’s drug developers still hoping for a homer http://www.biopharmadive.com/news/alzheimers-disease-lilly-biogen/446963/