CFRX – just announcing OK results for Phase I

by maddogdne | September 18, 2016 9:36 pm

Hello all –
Just hoping to perhaps draw Dr. KSS[1] out regarding his view of this company. They are working on using lysins from bacteriophage as antibiotic compounds. Lysins are complex proteins, which I presume they are producing by recombinant DNA tech, but the exquisite specificity of the phage is lost when just the lysin is created. So insofar as I can find, these lysins are entirely nonspecific in their attack on bacterial cell walls, so they will likely have as big a negative impact on our microbiome as they do on the pathogens. I would be a strong supporter of anyone attempting to develop ultra-narrow-spectrum antibiotic compounds with high specificity for pathogens, but another broad spectrum antibiotic compound I think we don’t need, as it will lay waste our pivotally-important natural microbiome in the process of hitting the pathogen(s), thus providing few real new advantages.

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