Michael Jorrin, "Doc Gumshoe"

Author Bio

Michael Jorrin, "Doc Gumshoe"
I have been a medical writer for about 25 years; before that I was a documentary film maker, and some of my films were about medical subjects. I am not a physician, but I have a pretty good scientific background. I wouldn’t dream of recommending any kind of treatment to anyone, and I cannot give medical advice. However, I understand the medical literature and the data and evidence behind it, and I have an inquiring and skeptical turn of mind. I scrutinize and question and, sometimes, challenge the positions of some of the established health-care organizations as well as the marketers of health information. Eternal vigilance is a small price to pay for health. — Michael Jorrin (aka DocGumshoe) Michael Jorrin is a paid contributor to Stock Gumshoe, he has agreed to our trading restrictions but he chooses his own topics and his words and opinions are his own.

Author Archives

It’s hard to stay away from the coronavirus pandemic, even though Doc Gumshoe basically has no information that’s any different from what’s flooding into your inboxes or TV screens or, for those of us who are still members of the ancient fellowship of newspaper readers, the pages of our daily newspapers.   But a few […]

The last time I wrote about Parkinson’s I had not yet become Doc Gumshoe.   It was quite a few years ago, and I was working on a continuing medical education project in support of donepezil (Aricept, from Eisai/Pfizer).   Aricept, as you may know, is one of a very few drugs approved for the […]

Having just devoted an entire Doc Gumshoe piece to the notorious coronavirus (COVID 19), I’m going to make those coronavirus updates brief – it looks to me as though the news media is devoting a major part of its capacity to covering most aspects of this pandemic – and, yes, it now certainly looks like […]

Don’t look to Doc Gumshoe to keep you up to the minute on the spread of the Wuhan coronavirus.   The figures I’m quoting below are as of mid-day today, February 18th.   These will have changed by the time you see this piece, and they may be unreliable in the first place.   But, […]

Please indulge Doc Gumshoe while he presents his musings on what’s going on in general in the health-care arena, and in particular, which new drugs are getting the FDA blessing and why, as well as which ones are getting the short straw.   My impressions and conclusions are in some cases only loosely based on […]

The headline that snagged my attention was this:  ‘Thirty-five Thousand Americans Die of Antibiotic-Resistant Infections Each Year” This was based on the Centers for Disease Control’s Antibiotic Resistance Threats in the United States, 2019, which led off with the statement that more than 2.8 million antibiotic-resistant infections occur in the US every year, and more […]

 “CRISPR” is the word in the headline that signals that the piece is going to be about gene editing.   Doc Gumshoe did not want to put that word – actually, it’s not really a word, but an acronym – in the title of this piece because gene editing is a whole lot more than […]

The many welcome comments to the Alzheimer’s piece that posted a couple of weeks ago prompt me to supply answers (if I am able to do that), but also set my mind to wandering on the fringes of a number of issues that may be of interest to the Gumshoe constituency. Anavex 2-73 At the […]

From where I sit, it seems to me that the entire landscape of Alzheimer’s disease (AD) has changed, and changed quite significantly.   The litany of announcements from pharmaceutical companies big and small revealing the unfortunate news that yet another promising agent for the treatment of AD has failed to meet its objectives in a […]

This particular bit of news leaves your friend Doc Gumshoe shaking his head in puzzlement.  To wit, in the US it is expected that there will be a substantial shortage of physicians in the upcoming years.   The American Association of Medical Colleges predicts that this shortage may reach about 122,000 physicians by the year […]

When we’re trying to fight against an adversary that is as strong and full of tricks as cancer, what we need to do is look for points of vulnerability – Achilles heels.   We all remember, of course, that the mother of Achilles dipped him in the River Styx when he was a tiny boy, […]

The publicity material for M. D. Anderson in Houston, Texas, which is perhaps the leading cancer treatment center in the United States, frequently includes a statement to the effect that they are committed to “ending cancer.” That statement puts me in mind of maps dating from the first century AD, in which large unexplored areas […]

One would think that it would take a person of normal intelligence about half a minute to conclude that lures such as the ones below could not possibly be on the up and up.   Here’s one.  It starts out with a note from Christine O’Brien. “The Sovereign Investor Daily A brand new, ‘Alzheimer’s vaccine’ […]

Doc Gumshoe is not in the habit of contradicting the conclusions, backed by research, that are stated in papers published by the Journal of the American Medical Association, commonly referred to as JAMA.    JAMA is, after all, one of a handful of the most prestigious medical journals on the planet, along with the New […]

“For such a beastly month as February, 28 days as a rule are plenty,” said the Pirate King.   But you would be surprised at the number of interesting snippets of news in the health-care realm that landed in my inbox during this short month.   I’ll lead off with one that gave me a particular kick. […]

What set me off on this rant was the very first comment on the piece that posted on January 31st, “Looking Backward – And a Peek in the Other Direction.”   Here’s the comment: “Thanks, Doc. Hope you will comment on the news out of Israel this week: https://www.jpost.com/HEALTH-SCIENCE/A-cure-for-cancer-Israeli-scientists-say-they-think-they-found-one-578939” Naturally, I looked, and what I found […]

Chances are not many of us observed New Year’s Eve with celebratory toasts to the glorious year gone by.   Rather, we bid goodbye to 2018 and hoped 2019 would be a better year – for ourselves, our near and dear, our country, and our planet.   However, as I wade through the volumes of healthcare-related stuff […]

I’ll grant that my headline is meant to be catchy and induce you to read this epistle.   Some of you will ask what is ketamine anyway, and most of you will know from the get-go that ketamine, whatever the heck it is, will turn out to be neither a menace nor a miracle, but something […]

Recent Author Comments

On Is "The End of Alzheimer's" Going to be "Jeff Bezos' Next Big Thing?"

Denali does have a drug, DNL 151, that penetrates the blood-brain barrier. It targets a gene that can lead to Parkinson's. - not Alzheimer's. Looks to me that if DNL 151 amounts to anything, Biogen will reap a big part of the profits. But if Dena[...]

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On Responses to Questions and Selected News Items

I’ve hugely enjoyed the wide-ranging comments that have come in during the past 24 hours. Gumshoe Nation, it seems to me, is representative of Planet Earth in microcosm. We, in the more developed parts of the world, seem to be emerging from the pande[...]

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On May Miscellany – Some Covid-19, Some Otherwise

Your problems are indeed challenging to the utmost. May your situation improve! However, all the evidence I have seen indicates that aerobic exercise in particular delivers the same benefits to the brain and mind as it does to the body.[...]

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On May Miscellany – Some Covid-19, Some Otherwise

Those vaccines do not make people immortal, but they do very effectively protect us from the most dire effects of the coronavirus - as well as depriving the virus of opportunities to multiply and infect others,[...]

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On May Miscellany – Some Covid-19, Some Otherwise

I don't know anything about Fasudil, but I'll put it on my lookout listl[...]

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On May Miscellany – Some Covid-19, Some Otherwise

Those of us who live in the parts of the world where the pandemic is easing up are extremely lucky. And India has been extremely unlucky. May its fortunes improve![...]

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On What’s New on the CRISPR Front?

If you're talking about Goosehead Insurance, that's outside my range.[...]

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On What’s New on the CRISPR Front?

Gerard, many thanks for your comment. I have not yet digested the content, but I will save it and read it carefully.[...]

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On What’s New on the CRISPR Front?

Thanks for the fix, best, MJ[...]

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On What’s New on the CRISPR Front?

As far as yielding any benefit in terms of treament, proteomics is in its infancy. The number of proteins is colossal. The research will surely turn up a great deal of interesting stuff, but there's not a whole lot for me to report on at this point.[...]

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On What’s New on the CRISPR Front?

I had never heard of it, and when I checked there was not a whole lot of information. What I did turn up was encouraging - that is, the results of the Phase 2B/3 trial in patients with COVID-19. I cannot comment on the stock as an investment. That's[...]

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On Does Phage Therapy for Infectious Diseases Have Potential as Antibiotics Fail?

Yes, the lysin has been named EXEBACASE. I wasn't going to get into lysins in this installment - it's a complicated subject. Lysins are what some phages use to destroy the exterior coating of bacteria. The Phase 2 trial was successful - we'll see w[...]

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On Where Are We in the COVID-19 Pandemic? – March 2021

As it happens, in a previous posting I discussed the MMR vaccine's effectiveness in preventing coronavirus infection in children & possibly also in adults.[...]

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On Where Are We in the COVID-19 Pandemic? – March 2021

Excellent question. I would venture a possible answer. Most transmission is by way of droplets rather than aerosols. Aerosols might be enough to cause infection, but not severe disease or death. Aerosols, but not droplets, can pass through the [...]

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On Where Are We in the COVID-19 Pandemic? – March 2021

I just checked the Feb 1 paper in The Lancet by Monk et al. Not sure how easy it will be for interferon beta to be given to patients at home. But on balance it looks promising. I'll keep an eye out for preliminary Phase 3 results.[...]

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On Doc Gumshoe's Responses to Comments and Questions

I'll check on those, but all the data I've seen so far indicates that the vaccines in current use are quite safe, especially compared with the risk of getting walloped by the coronavirus. Thanks & best, MJ[...]

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On Doc Gumshoe's Responses to Comments and Questions

I'm the wrong guy to ask![...]

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On Doc Gumshoe's Responses to Comments and Questions

Thanks - I'll check on the ones I missed.[...]

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On COVID-19 Prospects in the New Year

The specific citation for the correlation between vitamin D deficiency and COVID-19 is Jain A. Sci Rep.2020 Nov 19:10(1)20191 doi.10.1038/s 41598-020-77-93-2. A more general citation is Pereira M Crit Rev Food Sci Nutrition, DOI: 10.1080/10408398.2020.18[...]

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On COVID-19 Prospects in the New Year

You are exactly right! Thank you for pointing out that goof. By the way, I got my first shot of the Pfizer vac yesterday evening (HOORAY) and am due for the second in precisely three weeks.[...]

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