Blanco’s ” $2 Trillion ‘Bio-Switch'” Stock — he says it’s “Hailed as Miracle Drug for 3 Killer Diseases”

What's the latest biotech being teased by Breakthrough Technology Alert? Is there really news coming on Friday, March 15?

By Travis Johnson, Stock Gumshoe, March 12, 2019

Another day, another promise of imminent riches from a biotech clinical trial! This time it’s from Ray Blanco, who has made many such promises in his ads, and the pitch is all about a “bio switch” that has the potential to “end diabetes, plus heart & kidney disease (with a twice-a-day pill).”

What more could you want, right? Blanco says the market is valued at $1.98 trillion, but that this is a tiny little $3 stock — and he’s predicting FDA approval on March 15, 2019, which, in case you aren’t looking at a calendar, is this Friday.

So, naturally, once he’s got you fretting about a huge gain to come in just a couple days… this is the perfect time to say gosh, sorry, can’t tell you the details unless you subscribe to Breakthrough Technology Alert for $1,995. And, whaddya know, that $1,995 is non-refundable even if it turns out that I just made up the March 15 date, or the stock turns out to be lousy.

That seems a raw deal, and a foolish bet, so we’ll just figure out the stock on our own… then you can think it over, decide whether you like the risk, and use your $1,995 for something more satisfying. Or, heck, maybe once you hear about the stock you’ll be convinced of Ray Blanco’s brilliance and will want to send him your money… that’s fine with me, it’s your money, but don’t type in your credit card number just to get a stock tip. This way, you’ll know the stock in advance and have a chance to love or hate it before you pay for it, which isn’t always the way things work in this field (Remember the last time you bought a car? I bet you kept checking ads afterward to make sure you got the best price, right? Same with the last house you bought? Everyone wants to congratulate themselves for making wise choices, the human brain looks for validation for big decisions it has already made — so once you subscribe to a newsletter, most people are hard-wired to want to agree with the author… and if you paid $2,000 for a stock idea, you’re probably going to be hugely biased to BUY THAT STOCK RIGHT AWAY, with your critical thinking put on the back burner. What kind of dummy would spend $2k for stock tip and then not buy the stock? Sheesh!)

So anyway, what’s this magical stock? Clues from the ad for you:

The New York Times raves: “These [‘bio-switches’] are crucial… They can silence some genes and activate others.”

“And the doctor who discovered DNA thinks this science breakthrough is even BIGGER…

“In the race to find a cure, this Rocky Mountain biotech just blasted 7 years ahead of potential competitors — in a market valued at $1.98 Trillion….

“A massive investor in this company recently tripled down…

“Plowing $87 million more in anticipation of the predicted FDA approval…”

OK, so we can skip a few steps and say that yes, this teaser pitch is about epigenetics… which for those of us who don’t really remember much from our science days is defined thusly by NIH:

“What is epigenetics?

“DNA modifications that do not change the DNA sequence can affect gene activity. Chemical compounds that are added to single genes can regulate their activity; these modifications are known as epigenetic changes. The epigenome comprises all of the chemical compounds that have been added to the entirety of one’s DNA (genome) as a way to regulate the activity (expression) of all the genes within the genome. The chemical compounds of the epigenome are not part of the DNA sequence, but are on or attached to DNA (“epi-“ means above in Greek). Epigenetic modifications remain as cells divide and in some cases can be inherited through the generations. Environmental influences, such as a person’s diet and exposure to pollutants, can also impact the epigenome.

“Epigenetic changes can help determine whether genes are turned on or off and can influence the production of proteins in certain cells, ensuring that only necessary proteins are produced. For example, proteins that promote bone growth are not produced in muscle cells. Patterns of epigenetic modification vary among individuals, different tissues within an individual, and even different cells.”

So for our purposes, I guess epigenetic treatments for diseases don’t rely on doing gene editing (like the CRISPR stocks) that actually alter your DNA, but on modifying the way a gene is expressed… or something like that.

I’m a bio-idiot, so bear with me. I’ll focus on naming the company, then let you do the science-y bit. There’s also an interesting site here called “What is Epigenetics” if you want to explore more. (Oh, and that NY Times article cited is here, from 2016)

Other clues? Indeed, here you go:

“… the stock that could earn you a once-in-a-generation $1,032,031 windfall if you move before March 15, 2019 — when the FDA is set to approve its final clinical trial.”

Not sure what “approve its final clinical trial” means — the FDA does have to approve trial design, but what companies are really looking for in the end is for the FDA to approve the drug itself for commercial use. So that’s a little squishy… but that’s OK, because the dates in these ads are often made up anyway, mostly to give an artificial deadline to hurry you up as you dig for your credit card.

More from the ad:

“For millennia, this biological switch was hidden above the surface of your DNA.

“But since 2001, one company has been developing it behind the scenes…

“They’ve figured out how to take advantage of this natural anomaly to fix three of the world’s deadliest diseases…

“And they created a breakthrough treatment for heart & kidney disease, plus diabetes.”

Other clues? He says it’s “trading at just $3.06 per share” …

And “Seeking Alpha calls the stock ‘A Billion-Dollar Blockbuster in the Making.'”

Which is pretty silly for anyone who spends time perusing Seeking Alpha, since you can easily find extreme opinions on both sides of any stock there… with very little editorial control (not that Stock Gumshoe is any better, but, well, I wrote some for Seeking Alpha in its early days, years ago, and hopefully no one ever quotes me to validate their opinion about a stock’s future).

And he’s got a quote from the company’s 9/12/2018 earnings call…

“When we were finished with Phase 2, no other pharma or biotech had even started Phase 1.”

And the “seven years” quote is sourced to a hedge fund…

“The renowned NY-based Makalu Fund estimates they hold ‘a lead of seven years over potential competitive drugs.'”

More from the pitch:

“… they have a stunning sixteen patents protecting the lifesaving creation.

“Plus, I’ve found only 1 Wall Street analyst covering it.

“It all set to come to a head on March 15, 2019…

“That’s when they’re slated for a key FDA approval round that could trigger the catalyst to catapult every $1,000 invested into $158,770 over time… in its longer mission to end suffering.”

So who is this? We’ve got plenty more clues we could bore you with here, but that’s enough to get our answer — Thinkolator sez this is Resverlogix (RVX.TO, RVXCF OTC in the US), which is trading right around C$3 (in US$, the 52-week high was right around $3.06, back in September).

The drug in question is apabetalone, which works through an epigenetic mechanism called BET inhibition (bromodomain and extra-terminal), and the FDA did approve its plan and endpoints for the first big Phase 3 trial of the drug in Acute Coronary Syndrome (ACS). That trial was originally noted in their investor presentations last fall to have a “read out” of top line data in the first quarter, which I guess could make the March 15 date somewhat relevant, though in subsequent presentations they have been a lot squishier about that (in the latest investor presentation, they note that the trial will probably be complete in the first half of 2019 and that the top line data will be announced after the outcomes (SAE MACE events) are adjudicated, two or three months after the trial is completed. These are high risk patients, and it’s a Phase 3 trial so there are a lot of very sick people being treated… so my understanding is that this basically just means it will take some time to get the official judgement (from who, I don’t know) on which Serious Adverse Events or Major Adverse Cardiac Events might have been caused by the drug and which weren’t. The drug has apparently been judged safe in 1,900 patients so far over the years, but I assume this is their biggest trial yet.

That sounds more to me like we’ll have results from the clinical trial in the Fall, not on Friday this week… though who knows, maybe they will say something about how the trial is going at a conference — and they do have a poster session about this trial at a conference on March 16, though poster sessions don’t usually announce huge news (Resverlogix did announce yesterday that they’re participating in a bunch of conferences in the coming weeks, so you can peruse that list for other possible events if you like).

And yes, Resverlogix did get an $87 million infusion from one of their big investors, their Chinese partner Shenzhen Hepalink… but I’d call “recent” a bit of an exaggeration, that private placement deal was announced back in December of 2017. That got them through a few quarters, along with a $30 million loan last summer and another $30 million in shares issued late in the year (including a November private placement of $13 million that’s not in the filings yet), but a biotech running late-stage trials is a cash-burning machine and they’ll presumably need to raise money again soon (I’d guess they will probably have to do so in the next couple months, well before we have top-line results from their Phase 3 trial, but one never knows — maybe they’ll be able to do more borrowing or hit up one of their partners for more cash).

If you’re curious to see a bullish take, that hedge fund mentioned published its analysis a few months ago — you can download Makalu’s report, “Resverlogix — The Making of a mini-Humira?” here. I don’t know anything about Makalu or their track record, though the author does also note that this Phase 3 trial will be critical to proving their concept, with an argument for huge potential gains if there is a large and verifiable reduction in cardiac risk, and that they will need to raise more money. Makalu seems to think that a takeover is likely if the trial is successful, but that the risk is higher before trial results are in so any acquirer would prefer to wait for that ‘derisking’ event. Which makes some sense, though I had never heard of Resverlogix or Makalu before today so my judgement isn’t terribly useful here, either.

So I’ll leave you there, dear reader — think Resverlogix has the next big breakthrough in cardiovascular disease with their apabetalone? Want to bet on what the clinical trial results will be later this year? Understand the science better than I and feel like explaining for us? Just use the happy little comment box below to share your thoughts… thanks for reading!

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22 Comments on "Blanco’s ” $2 Trillion ‘Bio-Switch'” Stock — he says it’s “Hailed as Miracle Drug for 3 Killer Diseases”"

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I think the ticker is RVXCF

David M Paton

This is what I have found about their latest Phase 3 trial: “The BETonMACE trial is currently expected to be completed within the first half of calendar 2019, with third party adjudication of all MACE events anticipated to be available within two to three months past trial completion. The topline results of the study will be made available shortly thereafter.” I don’t know of any FDA announcement likely in the next few days.

Resverlogix Announces Participation at Prominent Industry and Investor Conferences March 16th, 2019 – Poster Session: Apabetalone, an Epigenetic BET Inhibitor in a Phase 3 Trial, Inhibits Vascular Inflammation and Cellular Adhesion Leading to Beneficial Outcomes in CVD Patients March 18th, 2019 – Poster Session: BET Protein Inhibition and Cognition: A Pre-Specified Substudy of the BETonMACE Phase 3 Trial Evaluating Apabetalone in Patients With Diabetes and Acute Coronary Syndrome 31st Annual ROTH Conference, Orange County, CA, USA, March 17 – 19, 2019 Ahead of the conference, a pre-recorded webcast will be accessible on the afternoon of March 11, 2019. Access the… Read more »
carl adrianopoli

Resverlogix has no ongoing clinical trial on the site. Not sure what they are addressing. There are some interim results as late as 2016, and two that will be recruiting, one for renal. Doc, thanks for the past help, you saved me some money. Should have paid more attention to your ADXS review, you were spot on, it is a huge loser. down in the quarter range last time I looked. Had always wished you would have reviewed IPIX (formerly CTIX). GLTY

Gordie Canuk

Carl, if you’d bothered to do a simple google search you would have found this: That’s for the Phase III BETonMACE trial, if you are able to do simple searching you’ll see that there are also planned trials for CKD and Fabry’s on as well…


Here’s a current Zacks report that will provide more clarity:


I read a pitch about a similar trial that was going to catapult the stock to the stratosphere. XOMA was the name. I came to Stock Gumshoe to see what it was. I bought the stock, the test failed, and the stock tanked. I still own the stock, but at least I didn’t have to sign up for the overpriced newsletter thanks to Travis. I keep thinking XOMA may get something approved that will run the stock back up to breakeven. I know – I’m not holding my breath.

EXTREME caution is due when evaluating biotech stocks, especially including those that describe altering DNA/RNA and/or its expression, to benefit patients with specific medical needs. Note the above comments, per currently available, effective dietary, etc. interventions. Case in point: Check out J. Gelsinger, a teenager whose parents agreed to have their son participate in the first, ever, genetic study, in order to try to save their child from cancer. He died. when he succumbed to what is termed unpredictable “cascade effects” = in this case, and in many more to follow, harmful sequelae, that claimed his life. Also note that… Read more »
Jim Thomas

This is what makes for the classic “resistance levels”: enough individuals bought at a certain price level, then the price went down. Now they all want the price to go back up to their break even point so they can get out.
If the price does go back up to that level, all that supply comes onto the market and the price will not go higher until it is all picked up by new buyers. Some potential buyers will hold off when they see that the price rise has stalled.
Classic “resistance levels” in action.

Bruce Macomber

Thanks for all the research! I’m going to buy a few shares, just for giggles. If anything awesome transpires, I’ll let y’all know.


This coming from the Cl&*n who promised us “Wireless phone charging”…over and over again….this guy is a hack!


Ray recommended this stock back in October and it has dropped 25% since then. Might be set for a rebound?

Michael Jorrin,

Many pharm outfits – Novartis, for one – are researching epigenetics, which is indeed a promising field. There will certainly be many drugs based on that mechanism. Does Resverlogix have an inside track? Just possibly.

David M Paton

For all who are sceptical about this company, do have a close look at page 16 of This shows that apabetalone had achieved a significant beneficial effect on the composite of death, myocardial infarction, stroke, heart failure etc and in the diabetes sub-group. If this continues to the end of this trial (not far off now) this could well be a major new drug in CVS disease!!

I looked at your link. I am a physician that does clinical trials. The red flag is that it is published in a really low impact factor journal. So obscure that I can’t access through my university library online system that subscribes to almost every mainstream journal. What does this mean? Usually researcher try and publish in the best journal possible. This article was probably rejected a number of times from mainstream journals due to some concerns with the study design. Overall, I find the story pretty compelling but I am just a little bothered by the above.
Posted this on Stockhouse and exactly a year ago: I have been in and out of this stock for the last 10 years. Since 2017 I do not own any shares for the following reasons: Stonegate extracts AND MY COMMENTS from the ABOVE REPORT: Since August 2000, Don McCaffrey and Dr. Norman Wong have been working together …… with an accumulated deficit of USD $366M as of 1/31/18. As of 1/31/18, the Company reported approximately USD $0.5 million in cash on hand with a reported average monthly cash burn rate of approximately USD $4.7M for the quarter. AND… Read more »
Gordie Canuk
To whomever published this article for Gumshoe, I would like to point something out. The article says: “Seeking Alpha calls the stock ‘A Billion-Dollar Blockbuster in the Making.’” That is not qute true. Firstly I wrote the article, I have an account on Seeking Alpha where my user ID is Joe Retail. While it is published there it is what they call an Insta-Blog post. As such on that site it is only available to those who are following me, however I am somewhat proud of what I wrote and I did share a link on sites like Twitter. Regardless… Read more »
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