Solving Ray Blanco’s “Alzheimer’s Disease is Now Completely Treatable” Teaser

What's the 25-cent prion-targeting stock that Agora's Breakthrough Technology Alert is saying will have a "miracle announcement" on February 14?

By Travis Johnson, Stock Gumshoe, January 20, 2018

This is a bonus weekend “quickie” for you, so it’s not a stock I’m going to go in depth on… but I thought you might want a few moments to think about it while the market’s not open.

The promise is absurd, here’s a taste of it from the top of the ad:

“ALERT: Agora Financial’s biggest prediction yet

“On February 14th a miracle announcement could give hope to millions… overturning three decades of stuck-in-the-mud research… and sending 1 microcap stock THROUGH THE ROOF…
‘Alzheimer’s Disease is Now Completely Treatable'”

That’s an extraordinarily bold prediction to make, but it’s also, frankly, a bit cruel — no, we are not going to hear that “Alzheimer’s Disease is Now Completely Treatable” on February 14. That’s a headline promise to get your attention, and, if we’re being charitable, a hope for the future.

And the financial prediction is equally nutty:

“The prediction? For the first-time ever, a true Alzheimer’s breakthrough could be just days away from being unveiled to the public… by an unknown, microcap company no one’s heard of. Based on a similar historical precedent, if this prediction is correct – and we’re nearly certain it is – it could result in a surge in company value of as much as $40 billion. Hard to imagine, but if that kind of sudden growth happens to the small cap company DETAILED BELOW, the result would be unprecedented:the largest two-day gain in stock market history.”

So what’s the actual stock? I said we’ll be quick, so I’m going to skip over a lot of the usual stuff… Ray Blanco calls their technology a “revolutionary ‘prion targeting’ protocol,” and these are the hints he drops about the company:

“A scientific breakthrough so advanced… so revolutionary… it’s now being recognized by the world’s leading brain researchers as apotential CURE for a disease they thought couldn’t be stopped

“It’s true. Including…

“Doctors at the Boston University School of Medicine, who published a detailed paper on the science behind this doctor’s research, concluding it ‘offers new hope to Alzheimer’s Disease patients and families.’

“The University of British Columbia, which has partnered with this doctor to bring this solution to Alzheimer’s patients as fast as possible.

“A panel of experts at the prestigious Alzheimer’s Association International Conference who recently reached a consensus confirming this theory.”

And he claims that there’s a February 14 announcement coming…

“On February 14, 2018, this doctor is going to gather the press at his companyheadquarters… stride up to the podium… and stun the world”

And that there has been a lot of insider buying…

“Just 11 men and women make up this company’s Senior Management Team and Board of Directors.
And would you believe over the last several months these 11 men and women… the doctor included… bought more than 10 million shares of the company?”

And “in the know” buying…

“… recently, the smartest, most connected insiders and biotech investors in the game loaded up on this one….

“Michael Bigger, the legendary scientist turned technology investor who made a name for himself with investments in Innovative Fibers, Netflix, Priceline, Amazon, and more. He recently snapped up saying…

‘This is a multi-billion dollar opportunity hiding in a dark alley… Never in my life have I seen a situation with such enormous potential and catalysts already at work… ‘

“Eden Rahim – who with annual returns that have put Warren Buffett to shame, you could consider the ‘Buffett of Biotech’- recently went all-in on this company, declaring…

‘I’m in it because of some of the really important insights it has discovered into the mechanism of action of Alzheimer’s disease… [It has] a really favorable risk/reward proposition.’

“A group of venture capitalists who insisted their identities be kept private. They didn’t just dip their toes in. They bought 18.7 million shares.”

So who is it? This is, Thinkolator sez, the little Canadian biotech ProMIS Neurosciences (PMN in Toronto, ARFXF OTC in the US).

And I’m not going to dig deep into this one, I just want you to be able to start your thinking on it. The important “slow your roll” item I want to bring to your attention is that the lead drug for ProMIS, PMN310, is still Pre-Clinical. That means it hasn’t yet been tested in a human being — this is a promising drug that seems to target toxic oligomers in the lab, but hasn’t yet been tried in a person.

Human trials, starting with an FDA approval to begin Phase 1, which has not yet been applied for, are at least a year away. Their investor presentation indicates that they are on track to initiate clinical trials in 2019 and “provide potentially superior clinical data vs aducanumab in late 2021” from their Phase II trials.

So yes, the company will likely have a quarterly report around February 14, but the most aggressive thing likely from that is some update to their timeline for applying to start Phase 1 trials (the IND application) at some point over the next year or so, or, perhaps some optimistic commentary about partnering with a larger company.

Blanco got many of his gushing comments about this drug from a Streetwise compilation of reports, it appears, so you can see that here if you like… or review the company’s investor presentation here.

Just do remember, please, that Alzheimer’s Disease drugs that are in the lab or even in Phase 1 trials are by their very nature exciting and hopeful… it’s when they try them on lots of human beings that reality has hit for most of the drugs we’ve seen advanced in the past, either because of safety concerns or lack of efficacy. The stock jumped 50% on Friday just because of Blanco’s ad campaign, but it’s still a tiny $77 million R&D company.

They say they’re “pursuing a Nasdaq listing, likely in 2018,” which could also have a big impact on the stock… and would be accompanied, I would assume, by some substantial capital raising — perhaps very soon They’ve been living hand to mouth by selling shares to raise the cash they burn through each quarter for the past couple years, but if they actually move to clinical trials they’ll need a lot more money.

The FDA is focusing on getting Alzheimer’s Disease drugs developed, and they have laid out several ways to speed up the approval process for these drugs… but that doesn’t mean they’re going to green light a drug that literally tens of millions of people would beg their doctors for without some clear indication of safety and at least a little bit of efficacy, so the clinical trial process is not going to go away, it can just speed up a bit. Which, of course, is not the primary concern for this little company because their drug has not yet even reached the point of applying to begin clinical trials… so cool your jets, ignore the promise of becoming a millionaire by Summer, look it over, and let us know what you think with a comment below. Maybe it will be a great winner, I have no idea, there are a lot of steps in between and investor enthusiasm could easily send the stock soaring after that kind of wild promise is made by a large financial publisher… but they’re not going to announce that they’ve cured Alzheimer’s Disease next month.

Over to year, dear readers… want to convince us either pro or con on ProMIS? Have at it with a comment below.

P.S. This isn’t the first time Blanco’s attention has been poured on an Alzheimer’s Disease stock — back in 2015 his teaser ad promises of a breakthrough, similar in tone to this ad, helped Anavex (AVXL) go from $5 to $15 in a matter of a week or so, though it came sharply back down when the reality of long-term clinical trials hit the stock. AVXL was far more advanced, of course, they were in Phase 2 trials at the time.


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63 Comments on "Solving Ray Blanco’s “Alzheimer’s Disease is Now Completely Treatable” Teaser"

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DrKSSMDPhD
Member
47654

We’ve pretty much broken the back of this one in the biotech threads. “Danger Will Robinson!”

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OracleofJersey
Member
18

Welcome back Doc, the stock market is just no fun without you.

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gregboyd703
Irregular
1

Please send links to the biotech threads on this subject

Gr8Full!
Member
11336
OSUfball
Irregular
161

A safe strategy when it comes to any drug involving Alzheimer’s would be to short it or buy put options. Sadly, most Alzheimer’s drugs fail clinical trials.

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goldtharhills
Irregular
12
One miracle drug is not going to solve what is a complex disease involving a number of bio challenges…more than 30, according to Dr. Dale Bredesen who has had amazing success in California over 30 years of research, demonstrating in documented clinical trials that his approach is helping people stabilize, partially recover or be cured. His “Bredesen Protocol” involves a myriad of suspects in Alzheimers, including heavy metal toxicity. His work is well documented as googling will reveal. My wife’s ex-husband lived with us for a year in 2016-7. He was 54 when he came down with early Alz. We… Read more »
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bstew
Irregular
23
Two very important things to consider are bad fats and sugar. Sugar causes glycation so the proteins don’t work properly, putting it simply. But fats are probably a bigger problem because we were sold a bill of goods with the margarine and Crisco lies/poison. The brain is mostly fat and a large part of that is cholesterol. You feed it bad fats and you have a bad brain. All vegetable oils and trans-fats need to be banned. They cause oxidative stress to the vascular system and brain. The trans fats add extra damage to the lipo-portein coating on HDL and… Read more »
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5000 Fingers
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0

I believe there have been no clinical trials or peer reviewed studies to date of Bredesen’s protocol. He is, however, a respected, credible and accomplished doctor – not a crackpot in any way. Following his protocol will make you a healthy and likely happier person… And there may be a connection to Alzheimer’s in that.

cocobolo
Member
81

It’s s shame that Blanco can’t be even remotely honest. Yes, it will be fantastic the day that Alzheimer’s is beaten, but February 14th of this year isn’t going to be that day. Unfortunately, I always equate anything that Blanco says with that big pile out behind the cow barn.

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Dave S.
Guest
0

Yep, there is a very wide gulf separating “Alzheimer’s Disease is Now Completely Treatable”” and “could give hope to millions”. Shame on them.

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tomjan
Irregular
15

Ray’s stock picks has my portfolio up 40% last year.

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bigger
Irregular
52
Disclaimer: I’m the largest shareholder in this company. I have no clue what the February 14th headline is. The way to think about PMN310 is a drug similar to Aducanumab that binds to the Toxic Oligomers but doesn’t bind the fibril (plaque) which is the driver of the Aria-E side effect of Adu. Aducanumab binds to both the toxic oligomer and the plaque. PMN310 doesn’t bind to the monomer. I’ll leave it at that given the size of my position. I had no clue this article was coming out yesterday and I have never talk to Blanco. I don’t know… Read more »
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schubrrw3212
Member
74
Mr Blanco may have his signals crossed. Another company with links to a potential Alzheimer’s drug has news due in litigation that’s set for Feb 14th. Kannalife and Isodiol International investor Marvin Washington is suing the US DEA for practicing medicine without a license. The lawsuit, Washington v Sessions, is up for hearing on a motion by AG Jeff Sessions to dismiss it so that DEA does not have to admit or deny the charges. Mr Washington bought the rights to US Patent 6,630,507 on a brain protection drug invented by 3 NIMH scientists, then hit a snag when trying… Read more »
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Dr.Fiero
Guest
0

That twat Sessions cost me ~10K on that stupid announcement! Which has almost no meaning in Canada here! Grrrr….

I’d love to hear Trump say “you’re fired” one more time at him.

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Mark T
Guest
0

I hope it IS a cbd-based wonder drug that proves the cure. GWPH could well lead the way to legitimizing cannabis based products out of Sessions dark age mentality. Been betting on it for a year. BTW if any of y’all are really serious investors, and gamblers, check out IMLFF pipeline as well.

Dean Gulbranson
Guest
0

Read or listen over an hour to Ray’s BS, then even though you have paid a membership fee in the first place, he just leads you on and on about all the money that will flow to you if you buy the stock shares he’s promoting for you. Now if you want the name of the company or stock it will cost you $2000 to get in. Maybe that will leave you with a couple hundred to put in. You cannot go for it if you don’t have a pile of cash to play with !

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Lonni
Guest
0

You can watch for the QTRLY $500 payment to pop up. If it doesn’t, you can call Agora for it.
A lot more affordable and you get the whole story!

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Mark T
Guest
0
I figured out who it was yesterday Travis, and when I saw it was pre-stage my immediate enthusiasm waned. However, if anyone is gonna find the cure for AD and ALS it IS this guy. He has been at it some 35 years and has won the prestigious Jonas Salk lifetime achievement lifetime award in this field. This Dr Neil Cashman and his newly public co. have proven that big pharma has been wrong and selling false hope for years to the victims of these diseases, his patented methods already have better results than any meds out there now, and… Read more »
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Mark T
Guest
0

Give Dr Cashman time! He has already shown that Big Pharma are the cruel ones. They have been selling useless meds to “treat” AD&ALS for years! I for one am gonna buy&hold this stock…even if nothing happens til 2021. Hear me now…and believe me later!

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Martha
Guest
0

Sounds like the PITS to me — Pie In The Sky.

David Goodrow
Guest
0

Despite the hyperbole, this company MAY be onto something. The approach I am taking is to buy, sell half at a double (hopefully) and then let it ride. Like any other interesting small cap.
Happy to see an insider speak up

drdave

4lllls
Member
21

I think Agora and all their staff might be good candidates for Alzheimer’s drug trials. I don’t like any of their styles of reeling in money to their coffers. They seem to forget that desperate people trying to save their loved ones , are looking for hope. It is very cruel to take advantage of them.

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jeremiahberndt
Guest
0

Agora has got to be the most audacious publisher. Fear mongering and click-bait don’t even begin to describe their sales tactics.

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Diane Anglin
Guest
0

I made the mistake of subscribing to Agoura last year. They sent me a post card with a number to call if I don’t want an auto renewal on my credit card. Called it to cancel and it’s a sex chat line.

saint stephen
Irregular
286

What was that number? LOL.

drog7nan
Member
4

Unfortunately, I have a family member going thru early stages of this dreadful disease so I didn’t appreciate Ray’s claim that there is a cure, etc etc — wish there was, obviously, Just another example of “fake news” — right? IMO

S. Sloan
Guest
0

Alzheimer’s is one of the most devastating diseases known to plague mankind. Better odds of cure with stem cell therapy, particularly with mesenchymal cells. Check out Dr. Neil Riordan in Panama and Texas. Early work is very promising .

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saint stephen
Irregular
286

A lot of supplement companies are pitching natural cures for aging issues. My mother is 92 and still sharp as a tack. Her secret? She swims three times a week even though she is legally blind.

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DrKSSMDPhD
Member
47654
My intent in commenting on ProMIS is not to make it look risible (I don’t question its sincerity in its approach and its belief in the authenticity of its work) but simply to caution investors and safeguard against capital losses. I see several issues about its approach that are not necessarily problems unique to ProMIS: (1) the amyloid hypothesis has serious deficits. Science cannot even answer why amyloid is elaborated, though we have made contentions in early commentaries about its origin. (2) Two major theories of the ailment have gained considerable momentum: these would be the dampened synaptic transmission hypothesis… Read more »
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bigger
Irregular
52

I’m not under an NDA with Promis and I don’t have any information that other investors do not have.

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senior111
Guest
0

Dr KSS.. So you are a bona fided MD.. or else you know a lot of medical terms strung together to sound reasonable. Thx for your scientific comments.

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GregBoyd703
Guest
0

Thank you for the detailed reply. I really appreciate your input and effort.

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Leo Graciano
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0

Lost big time on AVXL! Not interested in this. But can you tell us what the $0.70 cryptocurrency Jim Rickards teased us with this weekend (on Saturday, Jan. 20, 2018) is? And how to buy into it?

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Andy
Guest
0

Stellar Lumens (XLM) appears to be a close match. You would need to buy some Etherium (ETH) from the likes of Coinbase first then trade it for XLM on an exchange like Binance. Then I would recommend transferring them to a hard wallet device to take it offline so that you hold the private keys and can’t suffer loss from a hacking of the exchange.

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rbblum
Guest
0

I believe that it is Biogen that remains on the ‘fast track’ for its Alzheimers drug . . . It should be only a relatively short amount of time yet to determine whether it will be marketable or fall to the wayside. Current test results look rather promising.

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bigger
Irregular
52

Aducanumab is the only drug that has shown meaningful AD efficacy to date. I believe it will be approved (I don’t have a position).

GregBoyd703
Guest
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This morning’s press release: Humanized PMN310 Shows Significantly Greater Binding to The Toxic Oligomer Fraction of Alzheimers Disease Brain Extract Compared to Aducanumab TORONTO and CAMBRIDGE, Mass., Jan. 23, 2018 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (PMN.TO) (ARFXF), a biotechnology company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced further results of its previously announced and ongoing preclinical program for Alzheimers disease (AD). ProMIS is pleased to announce that its lead product candidate for AD, PMN310, compared to aducanumab (Biogen) showed significantly greater binding to the neurotoxic oligomer-enriched fraction of amyloid beta (Abeta) in… Read more »
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G. Miller
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0
My wife has had Alzheimers for 5 years. Currently she is on Namenda the only drug she tolerates. She has had very little regression and she still knows me and is very happy. Never complains about anything. She will forget something in 5 seconds. If she has ice cream and you ask her seconds later she says no I did not have ice cream. However she knows my name and her name and our daughters name. She knows a few of her sisters names. She loves to color and walks around with a book and colored pens. I know she… Read more »
Andy
Guest
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Have you investigated the effects of diet on her condition? Some useful links to explore at the bottom of this older post an a similar topic.
https://www.stockgumshoe.com/2017/11/whats-happening-on-the-alzheimersdementia-front/comment-page-1/#comment-4960037

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Leslie
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I feel for you .My husband is 83 and has been diagnosed with dementia several years ago and sounds a lot like your wife except he does not color and isn’t always happy. He was never diagnosed with ALzheimers and his original brain scans were free of plaques but showed brain shrinkage. He also takes Namenda and the patch. HIs regression comes in giant drops. this year after Hurricane Irma, last year after his daughters illness. he knows me, our dog, and his daughter, a few others but not their names. He is profoundly deaf and wears hearing aids but… Read more »
senior111
Guest
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Please watch “Bright Brains” on PBS by Dr. Amen.

catherine
Irregular
131

Mr. Miller, you appear to be doing so many things right, as your wife is very happy!

May I suggest 2 more? If you haven’t already found it, you might want to read another thread: https://www.stockgumshoe.com/2017/11/whats-happening-on-the-alzheimersdementia-front/comment-page-1/#comments

If you have old family pictures, you (or another loved one) might enjoy going through them with her and preparing a scrap book. If the scrap book never gets made, that’s fine – there’s joy in the memories of looking and talking about the people and events in the pictures.

Gr8Full!
Member
11336

#AD #Tunes Another joy to parents/patients with Alzheimer’s Disease is playing/listening to their favorite #music. Some may be found here at Magical Music Mystery Mining https://www.stockgumshoe.com/2016/05/microblog-magical-music-mystery-mining/ or youtube, itunes, soundcloud, etc Exercise, yoga, meditation, painting, socializing, going shopping, swimming, etc. may be of tremendous assistance as well… . #Best2ALL!

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bstew
Irregular
23
My dad was diagnosed with Alzheimer’s when he was about 80. I didn’t live very close but would take him omega 3, a good B complex with methylcobalamin and methyltetrahydrofolate (not folic acid). When I was there and able to guide his eating and supplements he showed marked improvement. As someone else mentioned in another post small amounts of lithium in drinking water has been associated with better mental health. Diet is very complex and needs some tailoring to the individual but avoid ALL vegetable oils and sugar. Use coconut, peanut or cold processed non-hydrogenated palm oil. Vegetable oils are… Read more »
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Gambini
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I read an article on researchers at MIT who engineered mice with AH of the brain and by aiming light at certain intervals (optogenetics) directly at each neuron , thereby eliminating the AH effects. The scientists then duplicated the effects by having the mice stare at this same light delivered at the same intervals. Human trials are expected in the very near future. Different approach than chemicals. I’m hopeful; lost a cousin to AH last year who developed it one yr after retirement at 62 yrs . His wife was the caregiver for 11 years; needless to say, they both… Read more »
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bakermre
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The only authoritative/reliable source on treatment published as/of late 2017 is Dale E. Bredesen, M.D. book: The End of Alzheimer’s, publ. by Avery, Penguin Random House, 375 Hudson St. N.Y., NY 10014. ISBN 978073516204. 36 specific factors that together are the principle causes of the disease are clinically identified and specific treatments for each defined. Hundreds of patients suffering from early to mid-stage Alzheimer’s have had recoveries recorded, documented by a widely respected peer group. Also see David Perlmutter, M.D. and Sara Gottfried, M.D. NY Times best selling authors on this affliction. Any other claim that fails to include Bredesen’s… Read more »
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senior111
Guest
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I have relatives who had or have Alzheimer’s. The impact on their families were profoundly difficult.

Perhaps next to a cure, a method to mitigate or retard the progress is very important. PLease watch PBS series on Bright Minds by Dr. Amen.

somewhatcautious
Guest
0
Alzheimers IS treatable in early stages and perhaps mid stage depending on individual, genes, etc. Dr. Dale Bredesen (google him) and his team are having some success. Having diabetes which I have controlled for 35 yrs with diet alone means I can live a reasonable healthy life but I can never put one bite of food in my mouth that contributes to worsening the disease and I believe the same about AD. It is an unending task to eat whole foods not coming out of a box but I am still going at 84. this year. A friend who was… Read more »
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Gr8Full!
Member
11336

SomeWhatCautious and ignorant