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What’s Dave Lashmet’s “Biggest Ever Breakthrough for treating Alzheimer’s Disease?”

Special Report now being promoted called The Alzheimer's Breakthrough Manual: How to Create Wealth with the One Biotech Stock Set to Change the World

What's Stansberry's Investment Advisory hinting at with a July 16 date for profiting from the "biggest health story of 2017?"

Alzheimer’s Disease always gets a lot of attention from newsletter publishers, readers and investors — not only because we all know someone who suffers from this terrible malady, but because we know that the current treatments are ineffective and the market is huge… which means that any real solutions or more effective treatments could create tremendous profits for the companies who discover and market them.

That’s been far more often promised than realized, however, as Alzheimer’s Disease has proven to be a tough nut to crack — not only because of the fact that you’re dealing with peoples brains and the side effects can be frightening, or because success or failure is often measured with pretty squishy instruments that try to standardize patient reactions when it comes to memory and the ability to deal with daily tasks, but also because there’s still a lot of uncertainty about how Alzheimer’s works, what causes it, and what might slow it down or reverse it.

The huge market and the huge human need keeps researchers going, of course — and it keeps pharmaceutical companies investing, even after decades of billion-dollar losses on failed late stage Alzheimer’s Drugs from some of the biggest companies in pharmaceuticals… hope springs eternal, thankfully, so hopefully we’ll soon see some far better drugs or treatments as our largest generation heads into its high-risk Alzheimer’s years.

And Dave Lashmet is pitching an Alzheimer’s Breakthrough to entice subscribers to sign up for Stansberry’s Investment Advisory … so what is it that he’s talking about? Here’s a bit from the order form:

“Profit from the Greatest Medical Breakthrough of the 21st Century

“By July 16th, we expect a major announcement on the biggest breakthrough for Alzheimer’s Disease EVER. Investors who get in before this date stand to gain the most — but you must act now…”

And Lashmet says he’ll be at the meeting in London where the latest news on this breakthrough is announced, and will be reporting directly to subscribers… but it’s also an ad for Stansberry’s Investment Advisory, not for Lashmet’s much more expensive Stansberry Venture newsletter, so presumably it’s a pretty large company (generally, they use their pricier newsletters to recommend smaller, more obscure or more illiquid stocks).

He refers to the drug as “B-37”, and this is the sum-up from the order page:

“Once an announcement is made, this stock could move quickly. All you need is a standard brokerage account to get started….

“Why the science behind B-37 is different than any treatment for Alzheimer’s before.
Our top medical and financial analyst, Dave Lashmet, dedicated four years of his life to tracking this new drug, meeting with the top neurologists in North America, PhDs at Harvard, and scientists from the most successful pharmaceutical companies in the world. You’ll find out why this drug works while hundreds before it have failed.”

So that’s probably enough to feed into the Thinkolator, but let’s check a few more clues…

He shows a series of MRI scan images of brains with “before” and “after” images of the plaque that is believed to cause Alzheimer’s Disease, with this sum-up….

“Notice, the plaque is all but gone in everyone, except the person who got no drug.

“These results are unprecedented in the history of treating this disease.

“Patients taking this new treatment wiped away 20 years’ worth of Alzheimer’s plaque in just 12 months.”

So… that sounds pretty exciting, and it did indeed get plenty of doctors excited and hopeful, there are several quotes from experts in the field about how promising and significant those results were (more on that in a moment).

And we’re also told that this drug is getting the green light treatment from regulators:

“This new blockbuster drug has already received what’s known as “Fast Track” designation from the U.S. Food and Drug Administration, so it can move through clinical trials quickly and get in the hands of patients who desperately need it.

“The European Medicines Agency granted it an even higher status — “PRIME” — for priority medication. It means European regulators will help oversee these trials.

“Keep in mind: This is the first and only neurology treatment to ever receive this relatively new program’s PRIME designation.”

So we’re really left with an embarrassment of riches when it comes to this “secret” stock, and I suspect many of you have already identified it… but here’s one more bit:

“The company behind this new drug is going ‘all-in’ to prepare for future sales. They know they’ve got a game-changer in the first drug to successfully treat Alzehimer’s.

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“For example, the company started by buying up a $75 million factory in North Carolina to jump-start production. And they recently broke ground on a $1.4 billion plant to produce the drug on a massive scale.”

So who are we being teased about here? This is biotech giant Biogen Idec (BIIB), which has grown over the past decade mostly on the strength of their several multiple sclerosis drugs, but has recently seen some worrisome possible competition creeping up in that area from Celgene (though Biogen also recently launched Tecdifera in that market, which is keeping their growth going as Avonex and Tysabri age), and is seen by some as having a relatively thin pipeline when it comes to late-stage drugs.

But the real game changer, of course, would be if their Phase 3 Alzheimer’s Disease drug does indeed turn out to be a huge hit — since that would, one imagines, have the potential to be one of the best selling drugs of all time.

That drug Lashmet is hinting at is aducanumab, a monoclonal antibody that they developed with Neurimmune (which discovered it and partnered it with Biogen ten years ago) — and no, Stansberry didn’t try all that hard to make this teaser impenetrable… they even used the same number, the identifier that Aducanumab has carried over the past decade is BIIB037, so “B-37” isn’t such a stretch.

If you’d like to get a handle on the drug and on expectations for it, most of the excitement came from releases from an earlier stage clinical trial last year that generated a lot of news coverage (and a bit of a pop in Biogen’s share price). The excited quotes from doctors that Lashmet uses in the ad mostly came from those stories in 2016, so I’d suggest reading those before you start to build a little understanding of the stock and the drug and the potential.

CNBC — Can this new drug slow the progression of Alzheimer’s?”

The Independent — “Alzheimer’s disease breakthrough as new drug clears toxic proteins from patients’ brains”

Toronto Star — “High hopes new drug could be a ‘game changer’ against long-incurable Alzheimer’s”

Biogen’s only has three drugs in phase 3 clinical trials right now, and one of the others is also aimed at Alzheimer’s Disease, that being their BACE1 inhibtor E2609 (a collaboration with Eisai).

So what’s the story with this July meeting in London? Well, Biogen will undoubtedly be at the meeting, what Lashmet is presumably referring to is the Alzheimer’s Association International Conference (AAIC) taking place from July 16-20 in London. Biogen has not formally announced that they will be releasing any new data on their clinical trials at this conference, and the Phase 3 trials for aducanumab are far from complete (they are still enrolling now, and their final data collection date for their primary outcome measure is 2019 and 2020), but it’s quite likely that updates will be released with some regularity as they begin to get a meaningful number of patients into the trials.

The last presentation I reviewed from Biogen, their first quarter presentation here, indicated that the aducanumab trials should be 50% enrolled by mid-May, so presumably we’re at least past that point. The company has not publicly said whether or when they’ll release any results, from what I’ve seen, but it’s a 76-week trial (roughly a year and a half, for the math challenged), and the first patient was enrolled back in September of 2015, with essentially all sites still enrolling new patients. They think they’ll be fully enrolled a year from now, according to management comments in the transcript of their last call, so I would guess that more patience will be required and we won’t get any big news from Biogen at the AAIC meeting next month… but I could be wrong, and I’m sure Lashmet is much more informed than I am on this drug’s progress.

Lashmet’s argument, made further down in the ad, is that they are going to have a critical mass of people who have been taking the drug for at least a year soon, maybe even past 1,000 patients with some long-term data already, and he hasn’t heard any bad news… which he thinks means there might be good news that would force them to present the data and, if the drug works, perhaps stop treating patients with the placebo and giving them the drug if they want it, bringing an early end to the trial because it’s so successful.

And he says the earliest date when there might be successful results shared is this July conference, though he also allows that it might take months longer or roll into 2018.

Whether or not they provide any update on the enrollment or initial progress of these first patients, or have some blowout early success that really shakes things up, the second quarter report (also in July) should be significant for investors because the company is going through a management transition, has made some more acquisitions, and is going to update on their progress at refining or refocusing their strategy.

The positive thing, I think, is that expectations are probably pretty low for aducanumab among investment analysts — everyone hopes it will do well and become a blockbuster, but analysts are probably really keeping their expectations in check just because every other monoclonal antibody that tries to remove amyloid plaque has failed, often in Phase 3 trials… and the Phase 1b trial that got everyone so excited last year was really different from a Phase 3 trial (they got exciting efficacy results as the plaque was removed in an impressively dose-dependent fashion, but also had a very small sample and were looking more for safety than for efficacy). Phase 3 trials in the past have been where Alzheimer’s Disease drugs go to die… which doesn’t mean this one will fail, but it means we should put pretty long odds on success and be cautious that it’s very early yet.

Beyond that, I don’t have any specific insight into either their multiple sclerosis drugs, which dominate the market, or on the chances for aducanumab or their other compounds in the pipeline, but the Morningstar analyst who follows this one, for example, puts the fair value at about $338 and expects 11% ongoing annual earnings growth, with the wide moat of their multiple sclerosis drugs, though some of that expected earnings comes from their Alzheimer’s drugs — she models $3 billion as the “probability weighted” revenue for those drugs by 2025, which implies actual sales, if they are approved, of more than $15 billion a year (which probably means, if you read between the lines, that she’s modeling in roughly a 20% chance that one of their Alzheimer’s Disease drugs gets approved and becomes a big seller within eight years).

Biogen is not likely to be a violent growth stock, not unless shockingly great Alzheimer’s news sends them rocketing higher and the drug is approved quickly, but it is profitable and reasonably valued based on the current business, with a forward PE of about 13 that doesn’t assume any Alzheimer’s revenue (which would be at least a couple years away even in a great scenario), and that valuation seems more than fair if they can grow at even a pretty slow pace — the same is true of lots of mature biotechs, though, like Gilead (GILD), and a reasonable current valuation is of little solace when growth-hungry investors see declining future revenue and risks in future drug development and sell the stock.

So I don’t know what’s going to happen in the future, but Biogen Idec is a strong and profitable company today, and there is certainly the potential for Alzheimer’s Disease profits to come their way in the future if their drug continues to be successful in clinical trials (though we should always keep some skepticism, honoring the fact that more than 99% of Alzheimer’s Disease drugs have failed in clinical trials so far). If you’ve got a take on aducanumab or their other drugs, or a bet on their future stock price, let us know with a comment below.

Lashmet has talked up Alzheimer’s before — last time out, I determined that he was pitching Biogen’s partner Eisai, so you can see our take on that pitch from last Summer here if you’re curious.

And, as always, if you’ve ever tried Stansberry’s Investment Advisory please let your fellow investors know what you think of it by clicking here to share your opinion (and if you’ve tried Lashmet’s pricier offering, Stansberry Venture, feel free to review that as well). Thanks!

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hedy1234
hedy1234
June 14, 2017 2:51 pm

I have subscribed to SIA for a while. It is a good service and I have made money. I bought Biogen when recommended last year. Results so far are flat.

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denton
denton
June 14, 2017 3:01 pm

No $ticker. For those who have loved ones suffering from Alzheimer’s Disease, as I do, perhaps this is an alternative to just another “pill”. No stock associated with this therapy…
v/r
jdd

https://nutritionfacts.org/video/best-aromatherapy-herb-for-alzheimers/

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aldosov
June 14, 2017 3:32 pm
Reply to  denton

Thanks! Will give it a try!

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denton
denton
June 14, 2017 4:12 pm
Reply to  aldosov

No $Ticker. Prorsum- I pray it will provide some benefit. This is an affordable, natural option that appears to have some efficacy. The other available options have failed to stop this ever growing destroyer of lives. And for those who’ve never lost a loved one to this unrelenting and destructive disease, I pray you never will. To those who want to add thumbs down, I am willing to take a hundred, if my message provided relief or some slight benefit to just one reader’s loved one…

v/r
jdd

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Eric
Guest
Eric
June 15, 2017 5:09 pm
Reply to  aldosov

Their track record is piss poor, careful!

Kenneth N. Shonk
Member
Kenneth N. Shonk
June 14, 2017 4:37 pm
Reply to  denton

Denton:

There are other natural treatments for Alzheimer’s that do not involve the use of phamacuetical drugs. Dr. Dale E. Bredesen (Buck Institure for Research on Aging – Novato, CA) has published the results of a small investigational study on 10 patients with mild to moderate cognitive with an Alzheimer’s diagosis. It successfully reversed the cognitive decline in 9 of 10 patients with the one failure the most advanced case. The protocol used is a 36 step protocol. The research is published in the peer reviewed journal Obesity in 2014 and 2016. You can download the papers for free from PubMed. Here is the link to Dr. Bredesen’s publications page: http://www.buckinstitute.org/bredesenPubs which has the links to the papers on PubMed.

There are numerious papers listed related to Dr. Bredesen’s Lab research on Alzheimer’s but the particular two that detail the 36 step protocol are these:

1) Dale E Bredesen (2014) “Reversal of cognitive decline: A novel therapeutic program.” Aging (Albany NY), 6:9 707-17
2) Dale E Bredesen, Edwin C Amos, Jonathan Canick, Mary Ackerley, Cyrus Raji, Milan Fiala, Jamila Ahdidan (2016) “Reversal of cognitive decline in Alzheimer’s disease.” Aging (Albany NY), 8:6 1250-8 .

Not all end diagnoses of Alzheimer’s have the same cause. My favorite quote from Dr. Bredesen is “there are multiple pathway to the same pathology”. About 25-30% of Alzheimer’s cases are related to build-up of toxic metals in the brain, especially aluminum but also lead, mercury, cadmium, arsenic. Dr. Exley at Kent University in the UK found that he could reverse 30% of Alzheimer’s by having the patient drink 1 liter per day of a natural spring water containing 30 mg/liter of ionic silicic acid (those waters equilibrated with volcanic rocks typically equilibrated with volcanic rocks often have this level of ionic silicic acid – Fiji Water is an example but there are others – see his lecture on YouTube and his 2014 paper). He is the world expert on the toxicity of aluminum in the environment. The silicic acid combines with the aluminum to form hydroaluminosilicates which cells excrete into the bloodstream where the kidneys can remove them.

Dr. Glenn Rothfeld is setting up an Alzheimer’s clinic in Waltham, MA that will use the Bredesen protocol.

Other processes that lead to the Alzheimer’s pathology include:
1)low grade inflammatory whole body and/or brain infections – Candida albicans, salmonela, Lyme disease, dental infectios from hidde infections from root canals especially, etc.)
2) non-metal environmental toxins such as pesticides (especially those with neurotoxic properties) and herbicides (glysophate for example).
3) development of insulin resistance in the brain (the risk of this developing is increased by toxic metals) – medium chain truglycerides which the liver can convert to ketones can be used in this case since the ketones can be used by brain cells for energy production.
Interestingly, amyloid proteins have been shown to have immune activity against brain infection agents, so the benefit from the removal of amyloid plaques my be short lived or deleterious if the brain infection agent isn’t also addressed. Targeting amyloid beta for removal may be based on an overly simplistic model of Alzheimer’s which fails to address the multiple causes which will be different for different patients. Perhaps this is why previous Phase III clinical trials targeting amyloid beta protein plaques for removal have failed. With regard to removal of amyloid beta from the brain the combination of curcumin from tumeric (lyposomal form is best) + Vitamin D (5000 to 10000 IU/day) + deep natural sleep (8-9 hrs/d) increases the body’s removal of amyloid which occurs principally during deep sleep betwe midnight and 4am.

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denton
denton
June 14, 2017 4:47 pm

God’s blessing upon you, my friend for sharing this information. I have already passed it on.
v/r
jdd

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Jeni B
Guest
Jeni B
June 20, 2017 7:56 pm

Very interesting. I’d like to know the level of lithium in the “natural spring water containing 30 mg/liter of ionic silicic acid”, as low dose Lithium – which naturally occurs in spring water – can also be protective against brain deterioration. WHAT ARE WE WAITING FOR has been said…except we can take low dose lithium as a supplement, it doesn’t have to be a pharmaceutical drug…which is likely why its not being promoted.

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vivian
June 14, 2017 3:07 pm

the problem with drugs to deal with brain plaque to cure Alzheimer’s is that we don’t know if one causes the other, and which way it goes. work on brain and central nervous system drugs (also against multiple sclerosis, Woody Guthrie’s disease, epilepsy, migraine etc etc) are being worked on by several major firms not just biogen idec.

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arch1
June 14, 2017 4:20 pm
Reply to  vivian

Absolutely true.

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Fabian
Fabian
June 14, 2017 3:17 pm

It looks like the market doesn’t really care. Buyable bottom at $ 245 , that’s only $ 7 away. But the downtrend is pretty steep.

Double Dumb
Guest
Double Dumb
June 14, 2017 3:25 pm

After Lashmet’s last pitch, I bought Eisai (ESALY) thinking that it was sure to double. I have received a couple of dividend checks since then, but I’m down from what I bought it at.

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Rich Abel
Irregular
June 14, 2017 4:26 pm

I do not know if this is the 1st Biologic to be used, but Biologic are used in many other disease entities and are highly advertised on TV. It seems like most of the advertising is of Biologics.The many disease entities that are advertised on TV may not be as grave to people as Alzhiemers is. I am not saying that the affected disease entities are not important, I am trying to say that Alzhiemers is in a larger percentage of people, as I believe it. Correct me if I am wrong. Anyway, IMHO, that’s my 2 cents.

pfrench42
pfrench42
June 14, 2017 5:41 pm

Announced their CFO is leaving for another company yesterday

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kblyons46
kblyons46
June 15, 2017 11:44 am

It’s not very well publicized yet, but there is pretty good evidence recently that the plaque that everybody has been viewing as the “cause” of Alzheimer’s is in fact a side-effect of a metabolic disorder that is far harder to detect. And there is some feeling, although I wouldn’t say it’s been shown really, that treatments that address the plaque per se in reality aren’t making much of a difference in the progression of the disease. The jury is still out on that, but let’s be careful not to assume that the disappearance of plaque in the brain scans mean that the disease has been cured. It makes a good story, but it might very well NOT mean that. There might be benefit to the treatment, since the plaque does interfere with some neural functions,, but it’s most likely not the end game.

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Michael Jorrin, "Doc Gumshoe"
June 15, 2017 1:50 pm

I discussed aducanumab & Biogen Idec back in 2015 after the Phase Ib trial results. What was particularly positive is that the clearing of the amyloid was linked with an improvement in cognition scores. But then another trial showed no efficacy at a higher dose. The question is, even if it turns out that amyloid plaque is the essential cause of Alzheimer’s, does removal of the plaque really restore cognition, or has some permanent loss already occurred? That said, Biogen continues to be a strong outfit, with other horses in the AD race, strong contenders in Parkinson’s, and other profit-making drugs. Best all!

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JOHN
Member
JOHN
June 15, 2017 9:39 pm

AVXL has been the leader for Alzheimer

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Jack Waserman
Member
Jack Waserman
June 18, 2017 5:26 pm

grammatical correction: “…anyone WHO can make real progress…”

diane
Guest
diane
June 16, 2017 2:15 am

Coconut oil shows promise to help with Alzheimer’s but of course drug companies can’t make money off it and you don’t have to wait or spend tons of money to try it. I cook with it daily.

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mosley1234
June 16, 2017 7:08 am
Reply to  diane

Essential fatty acids DHA &EPA also help considerably with brain health

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charles howe
Guest
November 14, 2017 3:18 am
Reply to  diane

how do you consume it? At what amounts? How often?

Dave Hanson
Member
Dave Hanson
June 18, 2017 8:45 am

Another outstanding piece of writing,Travis Johnson. Not much gumshoeing (sleuthing) needed on thisone, but g-r-e-a-t job of listing the likelihoods of things happening.I have little use for Stansberry because they hype possibilities (often longshots) as sure things in order to get into our wallets. In my view,they are like PT Barnum. They are not intellectually honest.

BASparks
Guest
BASparks
June 27, 2017 10:31 am

It’s surprising how many “experts” are ignoring or looking past AVXL. If one takes the time to understand the science and mechanism of action (MoA) that 2-73 targets, then one would begin to see the potential and likely success it will have. The Alz P2a trial data, to date, have all been positive, with stabilization to baseline after 52 wks. Not only is the MoA related to Alz, it’s also applicable to PD, HD, MS and ALS. It’s the same MoA; it just depends upon where the cellular breakdown occurs in the brain. Modulating the Sigma-1 receptor stimulates a restorative action within the cell, enabling it to return to normal function (if not too far gone).

Not surprisingly, the same MoA applies to neurodevelopmental diseases like Epilepsy, Retts Syndrome, Infantile Spasms, Fragile-X and Autism.

I think people’s eyes will start to open to AVXL as we progress through the back half of the year. Three trials will be starting: Retts P2, Parkinson’s P2 and a larger Alz P2b/3 (all funded by their respective sponsors).

Full disclosure: I’m very long AVXL and have been for over 2 yrs.

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BASparks
Guest
BASparks
June 27, 2017 2:39 pm

All of the failed drugs in the past had been targeting A-beta plaque, which has been proven to be an effect, not the cause. Anavex is the first to target the root cause… neuroinflammation… in a way that restores cellular homeostasis. A totally different approach with good results to date.

Anavex has not taken that long in its preclinical and clinical processes (2-3 years), compared to BP who has spent 10+ years and hundreds of millions of dollars. I’m a firm believer that 2-73 will be approved by the FDA (Retts) by the end of next year…then will be prescribed off-label for other indications.

There are several news topics due to come yet this year that will serve as huge catalysts for significant price appreciation. Institutions are still acquiring (ownership doubled in the past 6 months). I like having my investment along side Park West and Fred Knoll. Shareholders are in good company!

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advantedges
July 18, 2017 3:04 pm

Travis and others: so what recommendations are there for humans to reduce plaque in the brain? What can we do NOW to help ourselves besides drinking water from Fiji? (I have been to Fiji, and didn’t see people drinking their water -most were drinking beer!)

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Kenneth N. Shonk
Member
Kenneth N. Shonk
August 20, 2017 1:44 pm

Casey Research has promo for another company with a “breakthrough” Alzheimer’s drug that he calls Sig-1 that in a Phase II trial reversed Alzheimers in a substantial number of patients. The promo can be found at: https://secure.caseyresearch.com/chain?cid=MKT337775&eid=MKT338551#AST69941. Anyone know what company this is? It doesn’t match BIIB because is its supposedly a small biotech currently trading in the $5-6 range and the drug does not target removal of the amyloid beta plaque proteins.

Removing the amyloid beta proteins may be a mistake. Recent( late 2016) research at Harvard has shown the amyloid beta proteins are immune system proteins with activity against all tested pathogens include Lyme disease , candida albicans, and toxic metals like Al, Hg, Cd, and Pb. A recent study of the brain tissue of a small number of people who died of Alzheimer’s all showed brain infections of Candida Albicans. Dr. Exley’s research at Kent University in England has demonstrated that approximately 30% of Alzheimer’s cases are related to aluminum toxicity and that ingesting soluble ionic silicic acid (Fiji water with 30 mg/liter soluble silicic acid and similar waters and probably also the herbal supplement BioSil derived from the silica rich horsetail plant) enables the body to excrete accumulated aluminum from the brain and reverses Alzheimer’s in 30% of the small population of Alzheimer’s patients tested. (See Dr. Exley’s YouTube video) – The peer reviewed paper was published in 2014. Dr. Exley is considered the world’s foremost authority on aluminum toxicity and the behavior of aluminum in the geobiologic cycle.

Also, in any case, in case anyone has missed it. Early to moderate stage Alzheimer’s can be reversed using a 37 step protocol. The protocol was developed by Dr. Dale E. Bredesen, an Alzheimer’s researcher at the Buck Institute for Research on Aging in Novato, California. He has an extensive list of peer reviewed publications. The protocol and results were published in the peer reviewed journal “Aging” in 2014 and brain scan results in 2016. The protocol uses no pharmacuetical drugs. The scientific papers are available from Dr. Bredesen’s web page on the Buck Institute website through links to PubMed for free (I have copies). In addition, Dr. Bredesen is publishing a book on the protocol. The book, titled “The End of Alzheimer’s, THE FIRST PROGRAM TO PREVENT AND REVERSE COGNITIVE DECLINE, will be released on Auguste 22, 2017 (in 2 days). One can pre-release order the book from the following website: http://www.penguinrandomhouse.com/books/551532/the-end-of-alzheimers-by-dale-e-bredesen-md/#excerpt.
This is big news that I doubt you will hear about from the pharma controlled mainstream media.

The protocol is very similar to the Wahl protocol that Dr. Terry Wahl used to reverse her multiple sclerosis symtoms and which she has also successfully used to reverse Type II diabetes, treat traumatic brain injury (TBI), and reverse early stage Alzheimer’s and dementia. Her first peer review published paper on the protocol was publish several months ago though her book, The Walhl Protocol has been available and ignored by the mainstream media, the medical community, the MS Society, and most MS patients since it was published in 2011.

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rotundra9876
Member
rotundra9876
June 30, 2020 3:24 pm

Thanks for the update Travis!

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