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Stansberry Venture and their next “Biotech Buyout Watch” for a New Antibiotic

What's the "superbug" fighting stock teased by Dave Lashmet?

By xiexgp, March 26, 2015

Antibiotic resistance is a big deal, as you undoubtedly already know — and resistant strains of various cooties are becoming more and more of a problem, particularly in hospital settings where they seem to spread like wildfire among the sick, infirm and open-wounded, but elsewhere as well.

And the new wave of antibiotics is certainly making some fortunes as doctors look for new ways to fight these resistant bugs, and as the government in recent years has (belatedly) pushed on this oft-neglected part of the pharmaceutical research business — lots of big pharma companies stopped developing new antibiotics a decade or two ago, antibiotics in many ways became a victim of their own success when there seemed little additional profit to be wrung from that product category.

But now, of course, they’re back in the headlines — we need new antibiotics, and we need them now. The government has thrown drug developers a couple bones, in increasing the potential market for novel antibiotics and extending their patent life, and that has helped to make the investment case stronger… even if the market wasn’t obviously growing, as it is, thanks largely to overuse of antibiotics breeding ever more resistant strains of bacteria.

So that’s the context of the latest pitch for Stansberry Venture from Dave Lashmet — he recommended two biotech companies in this area last year that were bought out, Durata Therapeutics and Cubist, and he thinks he’s got another one that stands a good chance of a buyout later this year. Does he provide us with enough clues to tell you which company it is? Well, let’s see… here’s how he piques our interest:

“Phase 2 Showed 100% Success Rate

“Phase 3 Results Expected in 90 Days…

“One tiny firm set to explode….

“An announcement is scheduled for the middle of this year that will change the lives of millions of people… Including — most likely — your own.

“The announcement concerns the final clinical trial results of a drug so revolutionary, it’s the only one of its kind — and promises to cure a disease that kills more people than HIV and tuberculosis combined…

“This disease is caused by a class of pathogens that the Director of the U.S. Centers for Disease Control (CDC) says could ‘devastate our economy’ … and kill millions….

“For Americans, and people all over the world, the release of this drug could be as monumental as the discovery of penicillin.

“And for investors, it could mean a windfall…

“Because once the drug’s final clinical trial results are announced, I believe one of the largest pharmaceutical companies in the world is going to swoop in and buy this tiny drug maker to get its hands on the valuable drug they’ve developed…”

There’s quite a bit in the ad about the threat of “superbugs” and antibiotic-resistant bacteria, I won’t go into all of it but you can always check out the ad yourself if you like.

There is, however, more than one smallish biotech firm developing new antibiotics — and even more than one that will likely be releasing Phase III data this year. So which one is he talking about? Let’s see if we can sniff out any further clues:

“We must buy into this tiny firm before the phase 3 results are announced – which could be in a matter of weeks.

“I’ve tracked the final trial’s completion date — and all testing should already be finished.

“All that’s left is for the small drug maker to compile its data and announce to the world if its potentially life-saving drug is a proven success…”

OK…. that’s not enough. Anything else we can scare up in this long ad?

“I expect we have about nine weeks… But we might have just a few short days or weeks before the results are made public….

“It’s a tiny startup, and consists of about 50 employees, most of them scientists….”

And then a bit about where they are in clinical trials…

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“the results show that this tiny firm’s drug is working 30% better than the ‘standard of care’ in one of its Phase 3 studies.

“So from that perspective, the drug is already a success.

“The only thing we don’t know is if the drug works as a pill…

“See, the Phase 3 clinical trial for this drug was split into different studies to measure two objectives. First, to evaluate an intravenous (IV) version of the drug that’s already shown excellent results, and second, to explore the potential for a pill form of the drug.”

There are a number of relatively small, near “pure play” companies who are somewhere in the process of Phase III trials for new antibiotics (either just starting them or near completion), including Achaogen (AKAO), Cempra (CEMP) and Paratek (PRTK), but if we’re focusing on the likelihood of meaningful data in the next few months, and a planned filing for approval sometime in 2015, I agree with our reader who posted a guess yesterday: this is most likely Tetraphase Pharmaceuticals (TTPH), which is developing a drug called eravacycline.

You can see their latest investor conference presentation here for an overview, or a more detailed look at eravacycline here.

The shares of TTPH more than doubled in 2014, and they took advantage and raised a lot of money — in two tranches, the first in October and a larger second offering, at $35, just last week — so they are flush with cash, close to $300 million probably now (and a market cap closing in on $1.2 billion — the numbers in places like Yahoo Finance won’t reflect the latest money raise just yet), and they also may be eligible for additional funding from government antibiotic-spurring programs… so they’re not going to run out of money anytime soon (even in Phase III trials, they’ve only been burning through $20 million or so per quarter).

So far in 2015 the stock has been fairly flat — plenty of volatility, like almost every biotech stock, but it’s still in the mid-$30s where it started the year. They did release the positive Phase III topline results for eravacycline back in December, which helped to complete that spectacular year for the stock — that trial was IGNITE 1, for Eravacycline in Complicated Intra-abdominal Infections. The second Phase III trial top line results, for a combination of IV and oral treatment of complicated urinary tract infections (“iv-to-oral,” specifically — a more convenient dosing regimen), are expected “mid year” — though they’ve also said that they anticipate releasing “lead-in data” from that trial at a conference in April (the conference is 4/25-28), so perhaps there’s some anticipation that meaningful information will squeak out then. And yes, they do have about 55 employees as of the last report — so they’re not big enough to commercialize and sell the drug on their own, most likely, but with $300 million in cash they may have options beyond just selling out to big pharma.

And that’s all I can tell you — I’m not 100% certain this is the stock Dave Lashmet is teasing for his Stansberry Venture, but it’s the best match I’ve found for the somewhat squishy clues. I am not much of a biotech investor, personally, and I don’t have a handle on the market for novel antibiotics or what kind of sales and earnings might eventually be generated — Dr. KSS, who leads biotech discussions among the irregulars and has written quite a bit about new antibiotics, has noted TTPH only briefly in the past — he wrote early last year that he expected approval for eravacycline, too, but was not particularly excited about the opportunity for wide use and a financial windfall — but that may not be his current opinion.

So I’ll leave it there for you, feel free to suggest if you think I’m wrong on this guess — and no, I don’t usually like to give you a ticker symbol when I’m not certain — and I’ll leave it to the many wiser minds than mine to discuss or dig into the actual drug and its prospects. The company itself is well-capitalized, likely to file for FDA approval by the end of the year, and already valued at over a billion dollars. Over to you, friends.

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sdc
Member
sdc
March 26, 2015 5:43 pm

I am saddened and disgusted by the tasteless name-calling on both sides of the Dr. KSS “debate.” I read this website for enlightened discourse, not for some psychological need of readers, and in this case, Dr. KSS also, to show how knee-jerk nasty they can be.

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Harriman
Guest
Harriman
March 26, 2015 8:02 pm
Reply to  sdc

I agree. The reactions to the criticism were immature, defensive, using crude words, disgusting. If you have to defend yourselves with mudslinging, that is pathetic. I was about to become an Irregular. Now forget it. Who’d want to be in this group?

galhhudson
Member
galhhudson
March 26, 2015 6:32 pm

I see that this string is mostly about Dr. KSS. I enjoyed a free ride for a long time, using Stock Gumshoe, and after reading some very good things about Dr. KSS, I decided to spend a paltry $49 to become an irregular. I then read his Dim Sum article and invested in seven of the bio stocks he mentioned. So far, all have been a disaster, but I’m willing to give them a little more time. I think the $49 will prove to be well spent; and even if it is not, Travis deserves the recognition for the stellar service that is Stock Gumshoe.

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Alan Harris
Guest
Alan Harris
March 26, 2015 7:39 pm
Reply to  galhhudson

So YOU decided to invest in seven of the bio stocks he mentioned. (&) So far, all have been a disaster. So you want to blame someone else ? Where’s your responsibility….what was your other DD. Did you expect overnight riches for $49? Stop whinging and take some personal responsibility for your ignorance.
Oh you all make me sick.

Alan Harris
Guest
Alan Harris
March 26, 2015 7:59 pm
Reply to  Alan Harris

Does anyone truly expect that they can plant a $49 seed in the ground today and expect to be eating oranges by 8am tomorrow? If you have faith…have faith and hang in there. If you dont have faith, dont sign that cheque.

SDC
Member
SDC
March 26, 2015 9:23 pm
Reply to  Alan Harris

I think your advice and description of your illness are useless. See my
comment about childish snark four replies above.

tanglewood
March 26, 2015 8:44 pm
Reply to  galhhudson

Galloway; would you mind listing those seven stocks?

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mary
mary
March 27, 2015 10:42 am
Reply to  galhhudson

My bio stocks were up tremendously last week and down tremendously this week; that is the nature of the bio tech beast. Dr Kss evaluates the science behind the stock and also gives us an idea of a risk rating with the understanding all biotech stocks are risky. I have had best luck buying when the stock is first mentioned and holding until he says he has sold. I have had some losses and gained much. (bought ESPR @ 15).
I don’t know what you have but recommend patience and read Dr. Kss’s thread
daily…I was on vacation and missed when he said he had sold RNN ( last year) resulting in my not making as much as I could have…but it was still a winner. Welcome to the group!

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H.W. Hill
Guest
March 26, 2015 11:33 pm

Let me wrap this up. I am sorry that I created such a stir in the first place. I did say that Dr. KSS writes “very interesting and informative articles”. I would like to say that the nasty back and forth here is very uncommon and childish. I would encourage anyone following Gumshoe who is not an Irregular (paid subscriber) to seriously consider joining the Irregulars to benefit from the in-depth articles and analysis available to Irregulars.

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Alan Harris
Guest
Alan Harris
March 27, 2015 7:04 am
Reply to  H.W. Hill

If we go back to your original post; as you clearly knew about MEIP, you must be an Irreg. But there is no H W Hill listed as an Irreg. So it seems quite clear to me that you deliberately posted some rude comments with the clear aim of goading KSS, and did so while hiding behind an alias. That seems like an act of cowardly mischief making to me. Others may seek to excuse your treachery, but Je ne regrette rein. Nuff said by me on the subject.

Travis Johnson, Stock Gumshoe
March 27, 2015 8:00 am
Reply to  Alan Harris

To clarify for anyone who is concerned about privacy, Alan does not have a list of Irregulars. Presumably he’s referring to people who comment on the Irregulars articles and discussions — which is, as for any article, a small minority of the people who read the articles or comments. In no small part because of comment exchanges such as this one. If 100 people read an article, eight of them might read the comments, one of them might submit a comment. (That’s an illustration, I don’t know if it matches the numbers on Stock Gumshoe specifically — but you get the idea)

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LostOkie
LostOkie
March 27, 2015 8:57 pm
Reply to  Alan Harris

Nuff said by you, huh???
Well it’s about time!
I don’t understand why you got so paranoid defensive over this matter to begin with.
Must be some heavy insecurities there somewhere.

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Alan Harris
Guest
Alan Harris
March 28, 2015 6:26 am
Reply to  LostOkie

When a friend is unjustly attacked, you come to their defense….how else can you justify the title ‘friend’? Thats why so many others came to KSS’s defense I suspect….. He has EARNED a lot of friends.

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gard
Guest
March 28, 2015 2:39 pm
Reply to  Alan Harris

I don’t know Dr. Kss personally, so I cannot call him a “Friend”. And if I happen to disagree with him, then I will say so. He is not a God, and should not be treated so. And I should not be criticized for speaking up, that is what I see as a valuable asset of this website. Please, do not discourage dissent, even if you idolize Dr. Kss and haven’t yet experienced his ire.

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Alan Harris
Guest
Alan Harris
March 28, 2015 3:48 pm
Reply to  Alan Harris

Alan Pennock: I have certainly gone about these post the wrong way….. That’s my personal failing. You cannot possibly know, but via private emails with my friend KSS, I can assure you (and others could attest) I have been on the receiving end of KSS’s ire more often than the rest of you put together….and then some. But you do NOT abandon a friend just because they call you 3 sorts of b’stard on an off day. KSS is not a God: in fact, I know no one who has ever said it other than those who intend to insult (there are days when I would gladly label him as the Devil incarnate though) But I would say, he’s often been God’s gift to those Irregs who are interested in Bio investing. What I truly cannot countenance is someone saying (sic) ‘His advice is so duff, youd have made more money by shorting his picks’. Even that would be ok if there was some reasoned argument or justification. KSS has analysed literally hundreds of bio stocks…..does anyone expect a winner every time? Doesnt the person signing the cheque have a responsibility to do their own DD before signing that cheque? But when someone comes on with a one line unreasoned slur, it’s an insult to the intelligence of all those that read it, coz some may be fooled into believing it is true without checking. It was just a cheap shot at someone who has given blood to those paying a paltry $49, and in return for little personal reward . HW knew full well what (s)he was doing. They knew he can react badly to any unsubstantiated personal attack (who doesnt?), and decided to have some fun tweaking his beard. I suspect it was an act inspired by professional jealousy.
Alan P…By all means, publish your (collective) dissent. If its backed up with something substantial rather than a para of rude innuendo, I will be all ears. But to attack anyone (friend or foe) who has given so much to so many, is just stupid and plain rude. And I hope you will agree that stupidity and rudeness is not something any right minded person wants to encourage on SG.

Alan Harris
Guest
Alan Harris
March 28, 2015 3:51 pm
Reply to  Alan Harris

And that really is it from me !

Patricia
March 28, 2015 4:07 pm
Reply to  Alan Harris

Alan P. – Your comment makes little sense to me. Obviously the “other Alan” was referring to himself as Dr. KSS’s friend, not you, and yes he was defending a friend against the idiotic comment #3 and subsequent attacks. Dr. KSS’s great value to biotech investors is in identifying “junk science” companies, which eliminates most of the worst stock choices for people interested in the sector, and also in identifying some of what he considers the best and new and exciting companies. It’s clear to people who ACTUALLY READ his thread regularly that biotech is a very risky, specialized kind of investing and that this is not a tip sheet of any kind. High risk/high reward as repeated so often.

Sorry Travis, I wasn’t planning to come out of lurking this weekend to post anything, and I know you want the fight to be over, but this was too much. This “brouhaha” was not about discouraging dissent, it was about discouraging idiotic remarks by those who expect to just buy stocks they read about here and expect them to go up – right away and permanently, apparently. It takes more work and attention than that.

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seanmc
seanmc
March 29, 2015 3:31 am
Reply to  Alan Harris

Alan, you’re the best! Just ventured over here to see what all the fuss was about and love your relentless support and defense of our man…ignorance and stupidity should never be ignored.

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Pat
Guest
Pat
March 27, 2015 9:33 am

Love the site. Don’t usually read comments mostly because folks egos always get bruised at any criticism directed their way

Pat
Guest
Pat
March 27, 2015 9:36 am

Am considering becoming a subscriber. I suppose it’s referred to as an irregular

Travis Johnson, Stock Gumshoe
March 27, 2015 9:47 am
Reply to  Pat

Thanks Pat, we’d be delighted to have you.

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SoGiAm
March 27, 2015 10:07 am
Reply to  Pat

Pat-There is absolutely no better value for an investor available on the web IMHO.
Best2ALL!-Benjamin

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gard
Guest
March 28, 2015 2:43 pm
Reply to  Pat

I’d be delighted as well. It is well worth it, and don’t let the back and forth discourage you. Just know that it is necessary for an open and rigorous discussion. Enjoy

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mike
mike
April 16, 2015 10:40 pm
Reply to  Pat

I’m paying monthly not yearly….does that make me irregular? or is that because I skip my morning java on occasion? Kind of surprised by all the heat in here. I read a lot of comments because there is usually great info here. Not so sure anymore. I’ve read a lot on this one and gained VERY LITTLE! Can we get back to the heart of the matter? Sheesh!

Patricia
March 27, 2015 10:12 am

My 2 cents: we’ve elected presidents who had much worse tempers than Dr. KSS’s. Exceptional people always attract a lot of attention from both positive and negative personalities: both those whose primary impulse is to help, and those whose primary impulse is to destroy and “make nothing” of others. I think that’s where the phrase “temperamental genius” comes from – being attacked (and fed upon) more than the rest of us, they do tend to get a bit prickly.

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sparhawk
sparhawk
March 27, 2015 1:31 pm

I’m very happy to read Dr Kss’s posts. I always learn something and I enjoy his comments about the companies he writes about.
Travis is a very nice person and I enjoy his commentary and good humor immensely.

Bill

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Michael Jorrin (aka Dod Gumshoe)
Member
March 27, 2015 5:16 pm

Sorry to be boring, but sticking to the eravacycline subject, the chances that this drug – even if the Phase 3 data comes in rosy – will be a huge moneymaker are small. First, it will be held in reserve for use in patients in whom other antibiotics fail. Second, it will be copied by generics developed in countries where our patent laws are ignored or over-ridden for “humanitarian reasons.” Third, it is likely to be overused, leading once again to the emergence of resistance.
As for Dr KSS, my admiration for him knows no bounds. Best all, MJ

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Shailesh
March 28, 2015 12:28 am

Travis,
Here’s a tangent to move away from this brouhaha – any thoughts on Brett Jensen’s “Back-Door Access to a $3.35 Billion Market Opportunity” as a carrot to join his Small Cap Gems advisory?

deepdiver
Member
deepdiver
March 28, 2015 2:31 pm
Reply to  Shailesh

That would go in another thread.

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Mac
Mac
March 28, 2015 10:31 am

Travis is my hero.

gard
Guest
March 28, 2015 2:45 pm
Reply to  Mac

Mine too! lol

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GHHudson
Member
March 28, 2015 3:47 pm

Responding top tanglewood’s post of 26MAR15, I’d rather not identify the seven stocks, but six of them were up yesterday, and I clearly said I would give them a little more time. So, I do not understand where Alan Harris is coming from with his rude posts, which seem to be characteristic. Perhaps he should re-read mine (my first ever on Stock Gumshoe). I suppose an apology would be too much to ask.

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Alan Harris
Guest
Alan Harris
March 28, 2015 4:05 pm
Reply to  GHHudson

GHH: Ive tried CtrlF and find nothing other than the above post. Ehat do I need to apologise for? If I owe you some form of apology, you will have it writ large. Please give me the post number and thread so I can respond.

Patricia
March 28, 2015 4:19 pm

Just one more comment then I’m gone too: I think that possibly many of the “likes” given to Dr. KSS’s critics were people who, like me, lean more towards “natural” approaches to health than conventional treatments. I think that’s your real beef with him, because I just don’t think there are that many of you dumb enough to invest in biotech the way HW Hill did. Read all his articles and you’ll understand that though KSS at times makes statements that make some of us cringe – that’s just disagreement. He is a wonderful, compassionate, and understandably crusty genius of a man.

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goldnugget
goldnugget
March 29, 2015 1:06 am

With any newsletter one subscribes to, it is the individuals responsibility to do their own due diligence on touted stocks. There are no guarantees in life, and certainly not in investing, which is why a prudent investor always utilizes a stop loss to minimize, and avoid catastrophic losses.

It’s your money and you’re responsible for it, no one else is.

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stephen.e.mandell
stephen.e.mandell
March 29, 2015 10:24 am

Well !!
There certainly nothing Irregular about our irregulars !!
At the risk of completely mixing my metaphors… This back & forth, done on horseback with Knights in Dull Armor and running at each other with extended lances, blurting an insult as they pass each other, would make an hysterical Benny Hill episode.
Run at half-speed, of course, to qualify as “Half-Fast.”
Love you guys.
Suggest you make your point with “dislike” and no verbiage.
Even the weakest minded will eventually look at the (-) comments attached to their efforts to achieve fame and adjust.

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Benny Hill
Guest
Benny Hill
March 29, 2015 12:39 pm

Stephen: If you look very carefully, youll notice there is no ‘Dislike’ button….consequently, theres no balance in the system. Thanks for your suggestion though.

Art
Member
March 29, 2015 2:28 pm

Travis,
Would the content CEMP presented on March 18 and market action (Oh My!!) since then give you a clear cut answer. Just wondering. Thank you in advance, Art

Art
Member
Tom K.
Tom K.
March 29, 2015 2:49 pm

This may be a little off the subject (or maybe not) but the time to buy Tetraphase Pharmaceuticals (TTPH) was August of last year……. when it traded for about $10.00 per share.

Art
Member
March 29, 2015 2:57 pm

“One more thing!” — Colombo
I received this over the weekend from S & A Master Series:

The four new gram-negative drugs include:
1. Ceftolozane/tazobactam – now called “Zerbaxa” – which drug giant Merck acquired in its takeover of antibiotic maker Cubist Pharmaceuticals (intravenous, or “IV,” only)

2. Ceftazidime/avibactam, which is being jointly developed by AstraZeneca and Actavis (IV only)

3. Plazomicin, which is being developed by clinical-stage biotech firm Achaogen (IV only)

4. Eravacycline, which is being developed by biotech firm Tetraphase (IV and pill)
Closing footnote: “Out of fairness to Dave’s Stansberry Venture subscribers, we can’t give away the name of this biotech company.”
If you look closely at the companies’ application only one company fits, TTPH. Cute or a deliberate way to throw one off the trail. Maybe it’s CEMP which is not on the list.
Hmm!

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yochris48
Irregular
yochris48
March 29, 2015 9:56 pm

Don’t know if you guys got back around to the stock at hand- I skipped down here to the end. Anyway, I am a Flex member at SA, so I get a ton of emails from them. I am 90 percent sure they accididentally identified TTPH in a recent pitch email. They listed four bio tech firms that are introducing antibiotics, and they like TTPH because it is the only one that has the meds in pill form.

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74fcb22
Member
74fcb22
April 6, 2015 2:20 pm
Reply to  yochris48

well cempra
is developing an antibiotic ( Solithromycin) that would be also available in pill form

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