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What’s up with Stansberry Venture’s “Major FDA Announcement” Pitch?

Sniffing out the teased Obesity stocks from Dave Lashmet's Stansberry Venture Technology


This is the pitch that sent a bucketful of questions heading our way yesterday:

“Last Week’s Major FDA Announcement Officially Kick-started a Massive Opportunity

“A disease that 42% of Americans suffer from can now be cured. Our analyst tracked this story from the beginning, and he’s finally breaking his silence to reveal the name of the company that could soon produce the biggest drug in history. Its stock could climb 250% in the coming months alongside THREE other plays with 1,000% potential gains.”

Given the Biogen news this week with aducanumab, I thought this might be Lashmet following up on that Alzheimer’s Disease story… along the lines of, “if they’ll approve that drug, suddenly those other Alzheimer’s drugs don’t look so risky”… but no. He has pitched Biogen (BIIB) in the past, but today he’s again talking up obesity.

And obesity is probably the only untapped market that’s bigger than Alzheimer’s Disease, at least if you think of it broadly… so that’s where we’re headed today, as he tries to sell subscriptions to his Stansberry Venture Technology ($5,500/yr list price, though high end letters are pretty much never pitched at list price — it’s “on sale” for $2,500, no refunds, so I guess the undercoating and floor mats are free). More from the ad:

“This is something you never see. Up to 70% of the United States population could eventually be prescribed these drugs.

“To give you some perspective, that’s 38 times more than the best-selling drug to date, the arthritis drug Humira.”

Humira is not the best-selling drug in terms of the number of people who get it, of course, it’s not even in the top 50 (many of which are generic). It’s the best selling drug in terms of dollars (last I saw, the average cost was about $5,000/month). If a drug was priced anything like Humira and prescribed to 70% of the US population, money would lose all meaning, so don’t get too excited about that (that would be about $12 trillion dollars in annual sales, by my rough math, which is about 2/3 of total GDP).

And a little more about the big picture:

“I’m talking about a totally new class of drugs.

“They’re targeting a disease that kills around 5 million people every year.

“This disease steals an average of 15 years of life from those who have it.

“Including 42% of Americans… with more joining the list every year.

“There’s never been a cure, or even an effective treatment.

“But that’s all about to change.”

They give away one of these “freebie” companies, which turns out to be Novo Nordisk (NVO) (more on that in a moment), but the real tease is for the three small fry:

“… three of these companies are very small – around 100x smaller than companies like Pfizer or Abbott.

“Which sets them up for massive potential gains.”

So that’s our first clue, albeit a squishy one — Abbot (ABT) and Pfizer (PFE) have market caps of around $200 billion, so we’re looking for companies with a market cap that maxes out somewhere around $2 billion.

What else do we learn about this dread disease?

“With heart disease there are 74 different drugs on the market.

“The disease we’re taking about today has five approved drugs. And none of them work… except for the drug that was just approved by the FDA.”

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That’s the “catalyst” here, the recent approval of a new weight-loss drug from Novo Nordisk. That came late last week, when the FDA cleared an existing drug, semaglutide, for use as a weekly injection for weight management in people living with obesity who also have at least one comorbidity (high cholesterol, high blood pressure, diabetes, etc.). The drug has been sold as Ozempic for years now, used for glycemic control for diabetes, and also has a pill version called Rybelsus — the weight loss injectable packaging will call it Wegovy, and it’s anticipated that a pill version for weight loss will probably also be approved soon.

We’ve seen anti-obesity drugs before, and there are a few available right now, but it does sound like Wegovy is more effective than the other “mainstream” ones (ie, the ones that might be widely prescribed). In their clinical trials, 68 weeks of treatment led to 14.9% weight loss vs. 2.4% for placebo (you still have to eat less and exercise, too, but that placebo response tells you how successful “diet and exercise” is for many people). There’s a long list of side effects, but it’s not hard to imagine lots of prescriptions getting written — particularly if the pill form gets approved (the Phase 3 trials for the oral version are expected to begin this year, so it will probably be at least late 2022 before they could report those results or begin to apply for approval).

Here’s a little more of the tease from Lashmet about that oral version of semaglutide, since he does “give away” Novo Nordisk as his first recommendation:

“They trade on the New York Stock Exchange, and their first drug Semaglutide was just approved by the FDA.

“And I want to emphasize this point again. It doesn’t matter that you didn’t make it in before that approval.

“Because we know what many don’t…. that NVO has a second weight loss drug coming.

“It’s going to be bigger than the injection drug that was just approved… because it will be in pill form.”

Novo Nordisk (NVO) is a huge pharmaceutical company ($190 billion market cap), best known for their massive market share in the global insulin market and their variety of other diabetes care products, though they do also research and sell drugs in other areas. Whether or not Wegovy makes an impact on their income statement depends on marketing and insurance coverage… and in the first year or two, it might be fairly slow moving, and also might not show up as dramatic because it will also be cannibalizing sales from their first-generation weight-loss drug in this same class, Saxenda (liraglutide), which is also a weight-loss version of an existing diabetes drug. Diabetes will remain the big driver for Novo, I imagine, but they’re certainly betting big on building a new weight loss franchise — it just takes time. Sales of Saxenda are only about a quarter of sales of the diabetes version of liragluditde, which is called Victoza… the better results indicate that maybe Wegovy has a chance of doing better than that, but we don’t know for sure, sales might take quite a long time to build, and I am certainly not an expert on this stuff.

They include a couple quotes from luminaries that reinforce the breakthrough nature of semaglutide…

“I’d guess a lot of readers are skeptical this could be bigger than penicillin. But I’m looking here at some of the bullets you sent over.

“One doctor and Professor of Medicine at the University of Alabama called this ‘a game-changer.’

“He said more than half of patients in this drug trial saw results that no drug in history has ever been able to produce.

“Dr. Harold Bays, the medical director and president of a Louisville-based Research firm said:

“Y’all better buckle up because things are about to change. The world is about to change.'”

That Alabama quote can be found here, if you’d like some context, and the quote from Dr. Bays is from a CNBC story a couple years ago which also highlights some of the challenges weight loss drugs face in winning over doctors and insurance companies.

And then we get into some very light clues for the three smaller “secret” companies…

“….one of the other companies…. has already been designated a “breakthrough drug” by the FDA….

“And it’s not something the FDA hands out lightly. It points to something really big.

“Another drug in this class snagged a Priority Review from the FDA, because the potential benefit is so urgent.

“It’s hands-down the biggest market opportunity I’ve found in decades of writing about pharma… biotech… and scientific discovery.”

Any other hints about those other three companies and their drugs?

“The next dominos will be Drug number 2, 3, and 4. They’re much smaller companies I’m going to be sharing with my subscribers.

“They’re about a hundred times smaller, and they’re leading the pack in their clinical tests.

“Please, don’t get caught up on the idea that there can only be one winner. That’s almost never how situations like this work, where there’s a massive new market, with hundreds of billions of dollars at stake.

“I’m expecting all four of these companies to deliver incredible returns.

“But keep in mind – even if one of them doesn’t work out, that’s not a problem… but only if you play this situation just right.”

And yes, to be fair, Lashmet does repeatedly make the point in the pitch that he can’t promise what the FDA will do, or whether the drugs from these smaller companies will make it through to approval — he’s using a basket approach, it seems, buying a handful fo the most promising small companies with drugs he likes and counting on the fact that a 1,000% return from a big success would more than make up for the 100% failure of a couple others. I don’t dabble in biotech much, but that’s an important thing to keep in mind — small biotechs are often binary stocks, they either have great results or terrible ones and the stocks often react accordingly, and nobody knows for sure in advance which way a clinical trial or a FDA decision will go… there are no certainties. Even if you’re an expert (which, to be clear, I ain’t).

And then the story takes a turn, to treating not obesity but one of the major scary outcomes of obesity…

“Obesity develops into Fatty Liver Disease.

“And this is where this story is maybe a little surprising. And why there’s such a huge opportunity.

“Because maybe you’ve never thought about liver disease. That’s partly because a lot of people don’t know they have it.

“But this liver disease has quietly become the No. 1 most common disease in America.”

So that seems to be where at least some of his three smaller companies are focused…

“Let me give you an example. One of the drugs we’re covering today has found the right way to deliver messages to liver-filtering-cells.

“Those messages say,

‘Stop storing fat.’
‘Get rid of these fat deposits that have formed.’
‘Start healing the scars that have formed.’

“And those receptors within the liver cells are following those orders.”

Not a lot of other clues about those drugs or companies, he does add this:

“These new drugs could be the key to (1) righting the balance of fat stored in your body… (2) fixing the damage that has been done to your body and organs… (3) controlling your hunger to prevent the cycle from reversing.”

And we get one specific clue about one of the drugs, thankfully… they show an image from an MRI and make these comments:

“Do you see that glob of grey on the left side? That’s a liver filled with fat bubbles and scarring. 22.2% of their liver is filled with fat. That’s a liver that’s rapidly approaching total liver failure.

“Now I want you to look at this image:

“That’s a picture of the same liver… in the same patient. The liver on the left was before they were put on Drug #2. The picture on the right is after they were on the drug. For 12 weeks.

“100% of patients lost some or most of their liver fat….

“… a drug that’s the difference between a 0% response rate and a 100% response rate. For the late stages of a fatal condition.

“If that’s not a breakthrough, I don’t know what is.

“This company is sitting on the first drug to cure fatty livers.”

That’s Akero Therapeutics (AKRO), whose presentations include a perfect match to the MRI picture Lashmet shows in his ad. More on that in a few minutes.

Jeff Brown has also recommended this one in the past, FYI, he has posted free articles noting that he bought it in January and sold it in July last year.

How about the others? This is the only other clue that jumped out at me from the ad:

“One drug is about to enter phase three trials. Which means they are going to test it on a much grander scale. Word is going to get out soon, and I believe we’re going to see some big moves in the stock price when that happens.”

And, of course, he’s intentionally keeping those clues close to the vest… this is from the ad, too:

“I want to be even more careful about divulging the details of the other two. They’re tiny, tiny companies. The potential upside for my readers is astronomical.

“But if I give out too much information in this public forum… meaning the clinical trial results or details about these small companies – I’m sure you understand what can happen.

“Someone will figure out the names of the companies… broadcast them to the world for free… and wash out the opportunity for my subscribers, based on our own financial detective work.

“And I’m not willing to let that happen.”

Oh, come on now — if you demand $5,500, or even $2,500, with the dangling tease of a life-changing stock ticker, and won’t offer refunds even if the newsletter is a terrible fit for folks who sign up, or they got overheated by your marketing and maybe overcommitted, then we get to pick at you a little bit.

Yes, I know, caveat emptor — but if you can dangle a promise of a secret behind the curtain, we can pick at your clues and try to peek around the curtain a little. We aren’t trying to replace newsletters, we’re trying to help people think about top-secret teases and get some rational perspective before they plunk down $5,000 with no hope of ever getting it back — a “get rich” secret tip drives impulse purchases.

If you use a supermodel to sell a car, we should at least get to take a photo of her from her bad side, too. And remind potential buyers that maybe the supermodel won’t be in the passenger seat when you drive home.

Sorry, got off track there. Anything else about these obesity and “fatty liver” stocks?

“I watched from the sidelines as investors flooded the fatty liver disease market five years ago.

“They were chasing early results that worked on test mice. But not in people. Fortunately, science has now bridged this gap. We are seeing trial results in people that prove these drugs work.

“So for investors, this is a perfect set-up to make big returns. Because no one is paying attention.”

And other than the update that these stocks are “all in the public markets,” so there’s no sneaky private investment or other obscurity here, that’s about all we get.

We know, then, that Akero Therapeutics (AKRO) must be one of them. That is roughly a billion-dollar company — they’re pretty regularly presenting new bits of data on their efruxifermin (sometimes abbreviated EFX) drug for nonalcoholic steatohepatitis (common referred to as NASH), the latest readout of data that they presented was in March, and they seemed excited about it (the match for Lashmet’s MRI image clue is in their November presentation, if you want to be specific). The graphs look impressive, though I must confess that you should not listen to me on this — they could easily mislead me, I know nothing about liver disease. Seemed like there were some annoying side effects, but pretty substantial improvement in a good number of people. A couple cohorts of Phase 2b trials are ongoing or about to begin, with different groups and dosages.

I haven’t seen an indication about Akero receiving a Priority Review or Breakthrough designation from the FDA, but they have gotten that PRIME designation from the European Medicines Agency (EMA).

There are others, but no other real clues — so we’ll throw out a list of possibles for you to consider, if you’re so inclined. These are roughly in the order of “most likely to be in Lashmet’s portfolio,” though I confess that is based on little more than a Gumshoe “Spidey sense”… I’ve read that there are currently at least 40 different drugs in Phase 2 or Phase 3 studies for NASH, and quite a few of them are being run by pretty small companies:

Inventiva (IVA) matches on that “breakthrough therapy designation” in NASH for their lanifibranor, granted in October, and a FAST Track designation. They’re planning to begin dosing in their Phase 3 trial in the next few months, so that’s a good match as well, and they also have some other programs (two in clinical trials, including a collaboration with AbbVie on cedirogant for psoriasis that’s in Phase 1).

That’s also a pill, with a different mechanism of action than Akero (it’s a PPAR agonist), and their Investor Presentation includes some comparisons vs. the drugs from Akero, Madrigal and others when it comes to safety and efficacy. This one’s really small at a $500 million market cap, they IPO’d their ADRs in the US about a year ago and may be a little bit obscure for US investors (they’re French, and have been public in Paris for four years or so). There isn’t a lot of analyst attention and the share price hasn’t moved much this year.

Madrigal (MDGL) is the other one that’s close to a match, their resmetiron is just starting to enroll patients in their Phase 3 trials for NASH right about now, and that’s a 52-week study so results will take a while… though they do also say they expect top-line results from the similar study ongoing in NAFLD by the end of this year. NAFLD is nonalcoholic fatty liver disease, a broader indication, NASH is one type of NAFLD. The NIH explanation page is short and helpful if this is all new to you.

Madrigal is a heavily shorted (about 20% of the float is sold short), and their pill has shown some high efficacy numbers in the past. They just filed to raise $200 million in a stock sale last week, and their latest investor presentation is here (from April) if you’d like to see how they position themselves — they believe they will be first to market with a new NASH drug. And this is a one-trick pony, they don’t have any other drugs in the pipeline, so investors are at least somewhat confident in the prospects of resmetiron, too, or MDGL wouldn’t be a $1.8 billion company. I would assume that they’re likely to see a buyout a partnership deal next year if Phase 3 results are good, that’s a big market for a small company to take on on its own, but you never know.

I’d say those are probably the two most likely candidates, but there are several others I should mention as possibles — it has not gone unnoticed that NASH is a huge market, and a huge unmet need, and such things always attract researchers and new drug candidates.

Viking Therapeutics (VKTX) has its drug, VK2809, in Phase 2b trials for NASH — their corporate presentation here shows what look like pretty impressive results in reducing liver fat, without scary side effects.

89bio (ETNB) plans to start their Phase 2b trial of BIO89-100 in NASH soon, with top-line results by the end of the year.

Poxel’s (POXEL.PA, PXXLF) is a little more obscure for US investors, though Lashmet has had a propensity to pick European-listed biotechs in the past, and they claim pretty amazing potential in their presentations) — their lead drug is nearing approval for diabetes in Japan, but the one they seem most excited about for NASH is a variation of pioglitazone, which is well-studied in NASH, and they think their stabilized version will cut down on the side effects. I stopped understanding about halfway through their presentation, but you can take a look if you like.

NGM Biopharmaceuticals (NGM) reported topline results from one of their Phase 2b trials in NASH (they have two drugs in development for that indication, both in Phase 2, these results were for aldafermin), and the stock got almost cut in half on the news a couple weeks ago, so I guess that’s an indicator of how much investors like it when a drug fails to meet its primary endpoint. They aren’t giving up, they’re still enrolling other aldafermin trials, and sometimes those stock crashes on bad trial results turn out to be buying opportunities for companies that have other potential in their pipeline… but at least some of the bloom is off the rose.

Galmed (GLMD) os so tiny that it’s probably too small even for this newsletter, with a market cap of $90 million, but you never know. Their presentation back in January indicated progress in Phase 3 for NASH with Aramchol, with possibly some news in the next couple quarters.

And there are a bunch more… including the Indian company Zydus Cadila, which is known primarily for generics but claims to be first over the finish line with NASH approval in India last year for their proprietary drug Saroglitazar. That one can’t be easily traded by US investors.

Genfit (GNFT) had a drug for NASH called elafibranor, but it became one of the many NASH casualties last year, they’re hoping to repurpose it for other liver ailments.

Likewise, former NASH darling CymaBay (CBAY) collapsed just before the pandemic hit because of the failure of its NASH drug in studies.

Intercept Pharma (ICPT) has a drug for cirrhosis that’s been selling pretty well in Ocaliva, and they’ve been trying to expand the market for that drug to NASH… that program was granted Priority Review about 18 months ago, but then rejected by the FDA last year in a pretty big surprise (Intercept had already been negotiating with insurers and staffing up for their commercial rollout). Intercept’s investor presentation is here if you want to take a quick look, they seem to be holding out hope that some segment of the NASH population will benefit from antifibrotic capabilities of their drug — investors have clearly given up on their NASH prospects, and the stock has now lost more than 90% of its value since they first surged on their Phase 2 NASH trials back in 2014 (and 75% since the FDA rejection last summer).

There are lots of failures littering this market, so risk is high — even if you know a lot more than I do about it, as I’m sure Dave Lashmet does.

And he’s certainly not going to be picking an established pharmaceutical company here, but lots of them are also working on NASH, despite past failures — that includes Bristol-Myers (BMY), Eli Lilly (LLY), Roche (RHHBY), and, yes, Novo Nordisk (NVO) again.

The implication is also that he’s maybe talking up actual weight loss treatments, not just specifically NASH drugs… so I wouldn’t be surprised if he’s also throwing Rhythm Pharmaceuticals (RYTM) into the mix again, that’s a drug for weight loss in those with genetic disorders of obesity, and he pitched it pretty aggressively last Summer.

So… best guess? I’d bet he’s pitching Akero (AKRO), Inventiva (IVA) and Madrigal (MDGL) for NASH, but wouldn’t be surprised if he swapped out either MDGL or IVA for Rhythm (RYTM) in addition to the “freebie” pick of Novo Nordisk (NVO) — two obesity drugs, two NASH drugs, maybe that would be a nice balance. Other than Akero and Novo Nordisk, though, I should be clear that these are guesses.

He also hints at some other stocks that he likes which are still in “buy range”, including the “Universal Cancer Cure” — he doesn’t provide any detail, but it wouldn’t be surprising if that were the same one he pitched a couple years ago, when I covered that prior ad here.

And with that, dear friends, I’ll leave you to your own cogitating — I’m sure there are a great many Gumshoe readers who are more informed than I in all things biotech, so if you’d like to jump in with thoughts on NASH or any of Lashmet’s tease, please feel free to use the happy little comment box below. Don’t worry, we don’t bite.

Disclosure: I don’t own any of the companies listed above, and per Stock Gumshoe’s trading rules will not trade in any covered stock for at least three days after publication.

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Jeff
Guest
Jeff
June 9, 2021 1:14 pm

I’ve been burned by two of his picks in the past, Rhythm Pharmaceuticals (RYTM) and Esperion Therapeutics (ESPR). Both had large spikes and then seemed to fall off of a cliff. So, being wiser and poorer, I only bought one share of NVO this morning at $83.38.

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cartero
cartero
June 9, 2021 3:12 pm

“No man has the right to be an amateur in the matter of physical training. It is a shame for a man to grow old without seeing the beauty and strength of which his body is capable.” Socrates
Wouldn’t it be cheaper and more beneficial to emphasize exercise and healthy diets to defeat obesity? Since the mass media, politicians, including the president, and celebrities have been able to convince a majority of Americans to get vaccinated, couldn’t they do the same thing for combatting obesity. Especially since obesity is responsible for more death and sickness than any corona virus.

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timcoahran
Irregular
June 9, 2021 4:14 pm

Hear Here!

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eleanorxduval
eleanorxduval
June 10, 2021 3:31 pm
Reply to  cartero

Great concept but diet and exercise is a lot of work and take so much discipline for us humans. A pill is so easy. I am totally agreeing with you though.

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woody pang
woody pang
June 9, 2021 6:17 pm

I subscribed to Lashmet’s letter three years ago. While I did not take all of his suggestions, I did invest in BIIB, INO, LMT, MAXR, NVDA, NVO and ORA and have been pleased.
I have reached the point in my investing career where I have decided to cut back on listening to webinars on what to buy. Over the years, it has cost a tremendous amount of time and made my portfolio too unwieldy. There are just too many names to follow. Most of the time, I would take a recommendation and buy a small amount, like 100 shares.
But with 100 shares of a $10 stock, even if that investment doubled, I would make only $1,000. And not all of the choices turn a profit. Not hardly.
On average, I probably could make 50% for a profit of $500.
So suppose I have one winner each month at $500 each, and i would probably have losers giving me a net of $250 per month. These are just made-up numbers to illustrate, and are probably optimistic.
Making $250 per month would give me $3,000 over a year’s time.
That would certainly be enough to pay for one of my subscriptions.

But it’s not enough to pay for any additional subscriptions, and it’s not enough to build wealth.

Over the last few weeks, I have stopped listening to webinars, and stopped reading recommendations from nearly all sources, even those that I paid for. I decided to no longer add any new entries to my portfolio, except when I find a good opportunity from Lashmet’s Venture Technology. And I always check with Stock Gumshoe.
By being careful with how I approach the investments, using options and larger bets, I have doubled the value of my portfolio in the past 12 months. I finally feel that I have a handle on my investments.

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eleanorxduval
eleanorxduval
June 10, 2021 3:35 pm
Reply to  woody pang

I feel the same. Too much information and definitely a lot of research. I have so many stocks in my portfolio, it is a full time job.

But I always value Travis’s opinion and research.

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bravobill
June 9, 2021 6:27 pm

I don’t think Lashmet mentioned RYTM this time. It was a COVID related deal in the beginning, obesity being the condition it is.

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bravobill
June 10, 2021 4:46 pm
Reply to  bravobill

You missed this one bravobilly, wake up! (I was wrong). Mr. Lashmet sees RYTM in the wings waiting for the stage to clear.

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Dana McReynolds
Member
Dana McReynolds
June 9, 2021 7:15 pm

Any time I see a newsletter writer opine “100X smaller…”, I know they’re an ignoramus and reading their pitch is a waste of my time.

Good work on your part as usual.

William Dunn
William Dunn
June 10, 2021 12:28 pm

Jeff Brown has been wrong many times. I jumped on Homology (FIXX) when he pushed it, and I’ve been losing money ever since.

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Cubes
Guest
Cubes
June 11, 2021 12:44 pm

Im always amazed at your uncanny ability, Travis, to decipher clues from newsletters (please read as compliment!) Ive been a Stansberry Alliance member for a long time. Some analysis in listen closely, some i dont even bother to read their research. Lashmet is one of the analysts I give more listening to. No one gets everything right all the time, but he hits some out of the park. Ive lost on plenty of their recommendations, but have made back my investment in their services easily 20 times over. These guys get paid to make stock recommendations. But maybe people give too much trust in them. Yes, in theory, they know more than we do in their area of expertise, but if you are investing your own hard earned $, you should also take a little time to do your own research. If you like it, buy it, if it doesnt sound so great..pass.

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Cathy Schlecker
Member
Cathy Schlecker
June 13, 2021 12:09 am

Does anyone know anything about Karolinska Development AB (KDEVF) There is an article in Science Daily that Karolinska Institute “Researchers have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. As I understand it the Institute is blended research at the university with the Stock Market and trades as KDEVF. on the Nasdaq. These finding were announced Feb 2020. Are any drugs being developed around these new findings?

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mikllee
Member
June 13, 2021 3:14 pm

I just read a brief article on Ne wAtlas.com That confirm Novo Nordisk as the company and provide a little more detail….. https://newatlas.com/health-wellbeing/semaglutide-weight-loss-drug-fda-approval/?utm_source=New+Atlas+Subscribers&utm_campaign=b0bdad1659-EMAIL_CAMPAIGN_2021_06_11_07_21&utm_medium=email&utm_term=0_65b67362bd-b0bdad1659-92670821 …… there were 6 comments attached to it. They we interesting and one longer on seemed very well reasoned.

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