The last time I wrote about Parkinson’s I had not yet become Doc Gumshoe. It was quite a few years ago, and I was working on a continuing medical education project in support of donepezil (Aricept, from Eisai/Pfizer). Aricept, as you may know, is one of a very few drugs approved for the […]
Articles
Having just devoted an entire Doc Gumshoe piece to the notorious coronavirus (COVID 19), I’m going to make those coronavirus updates brief – it looks to me as though the news media is devoting a major part of its capacity to covering most aspects of this pandemic – and, yes, it now certainly looks like […]
Today we’ve got a teaser pitch from Dylan Jovine’s new service, Takeover Targets, which he says is “half price” for charter subscribers (that would be $997/year, and unlike many higher-end newsletters they say they do offer refunds for 30 days)… and, as you might imagine, the service is all about identifying companies that might be […]
The many welcome comments to the Alzheimer’s piece that posted a couple of weeks ago prompt me to supply answers (if I am able to do that), but also set my mind to wandering on the fringes of a number of issues that may be of interest to the Gumshoe constituency. Anavex 2-73 At the […]
From where I sit, it seems to me that the entire landscape of Alzheimer’s disease (AD) has changed, and changed quite significantly. The litany of announcements from pharmaceutical companies big and small revealing the unfortunate news that yet another promising agent for the treatment of AD has failed to meet its objectives in a […]
One would think that it would take a person of normal intelligence about half a minute to conclude that lures such as the ones below could not possibly be on the up and up. Here’s one. It starts out with a note from Christine O’Brien. “The Sovereign Investor Daily A brand new, ‘Alzheimer’s vaccine’ […]
I have no idea what’s going to happen in the market today, but perhaps if I spend my time looking into a teaser pitch from a new newsletter I’ll be too busy to obsess over my portfolio and do something dumb during the trade war panic gyrations. Sound good? Want to join me? Great! The […]
Here’s the lead-in to the ad that caught our readers’ attention this week: “This ‘Perfect Storm’ Stock Is Set to Deliver Big Pharma a Swift and Devastating DEATHBLOW It Won’t Come Back From… “And Launch This Little Company on A 72-Hour, $8.98 Billion All-Out SPRINT” And there’s a deadline… today, in fact, when there will […]
I’ll grant that my headline is meant to be catchy and induce you to read this epistle. Some of you will ask what is ketamine anyway, and most of you will know from the get-go that ketamine, whatever the heck it is, will turn out to be neither a menace nor a miracle, but something […]
Ray Blanco makes (part of) his living looking for biotech moonshots, like most biotech-focused newsletter writers — and like his predecessor at Agora’s biotech and emerging tech-focused newsletter Breakthrough Technology Alert, he has often touted companies that are trying to end the scourge of Alzheimer’s Disease. Why? Well, two main reasons: First, and by far […]
Is this going to be good news, or bad news, or somewhere in between? On balance, I would say good news, simply because the research and investigation is going on at an intense pace. Currently there are 1,903 clinical trials underway at some stage, in the US and all over the world. When I first […]
This is a bonus weekend “quickie” for you, so it’s not a stock I’m going to go in depth on… but I thought you might want a few moments to think about it while the market’s not open. The promise is absurd, here’s a taste of it from the top of the ad: “ALERT: Agora […]
[ed. note: Michael Jorrin, who I dubbed “Doc Gumshoe” years ago, is a longtime medical writer (not a doctor) who writes for us a couple times a month about health issues and trends. He does not typically focus on specific investment opportunities, but has agreed to our trading restrictions… as with all of our authors, he […]
We are always, always tempted by anything that promises hope to sufferers of Alzheimer’s Disease and their families… not just because we’re humanitarians and love people, and have seen the pain of this disease, but because Alzheimer’s treatment is by far the largest (mostly) unmet medical need in the US, both because the population of […]
[ed. note: Michael Jorrin, who I dubbed “Doc Gumshoe” years ago, is a longtime medical writer (not a doctor) who writes for us a couple times a month about health issues and trends. He does not typically write about specific investment opportunities, but has agreed to our trading restrictions… as with all of our authors, […]
[ed. note: Michael Jorrin, who I call Doc Gumshoe, is a longtime medical writer (not a doctor) who writes for us about medicine and health a couple times a month. He has agreed to our trading and disclosure restrictions, but does not generally write directly about investment ideas. His ideas, thoughts and words are his […]
Alzheimer’s Disease always gets a lot of attention from newsletter publishers, readers and investors — not only because we all know someone who suffers from this terrible malady, but because we know that the current treatments are ineffective and the market is huge… which means that any real solutions or more effective treatments could create […]
[ed. note: Michael Jorrin, who I like to call Doc Gumshoe, is a longtime medical writer (not a doctor) who writes about non-financial health and medical issues for us a couple times a month (past submissions can be found on his author page here). Like all of our authors, he chooses his own topics and […]
[ed note: Michael Jorrin is longtime medical writer who has been sharing his thoughts with our readers as “Doc Gumshoe” for several years (he’s not a doctor, I gave him the name). He generally covers medical and health news and sometimes health promotions and hype, but he rarely opines about investments or specific stocks. All of his past […]
Alzheimer’s Wrap-Up[ed note: Michael Jorrin, who I like call “Doc Gumshoe,” is a longtime medical writer who shares his thoughts with us a couple times a month — his articles are non-financial in nature, his words and opinions are his own, and you can see his bio and his past pieces here. Enjoy!] Indulge me while […]
[ed. note: Michael Jorrin, who I like to call “Doc Gumshoe,” writes about health and medicine for us from time to time. His columns are not generally focused on investments, though this one does include some commentary about a number of specific companies (most are not publicly traded). His words and opinions are his own, […]
[ed. note: Michael Jorrin is a longtime medical writer who writes about health and medicine a couple times a month for our readers, usually without a specific investment focus — though it so happens that today’s topic, Alzheimer’s, is also subject to at least one current heavily-hyped investment pitch. I like to call him “Doc […]
10/28 update: this article is about a week old, but the teaser ads have changed a bit — the newsletter is now also being pitched under the headline, “Has this Maine town bottled the fountain of youth?” and it’s now also going out under the name Dr. Richard Robinson, who apparently works on the newsletter […]
[ed note: Michael Jorrin, who we like to call “Doc Gumshoe”, is a longtime medical writer (not a doctor) who writes non-investment articles about medicine and health topics for us once or twice a month. As with all of our guest contributors and columnists, he chooses his own topics and his words are his alone] […]
That’s a subtle headline, right? I already issued a bit of a “brain dump” for the Irregulars this week, on Wednesday instead of Friday, but I couldn’t resist taking a little look at this latest teaser pitch from Patrick Cox for his Transformational Technology Alert. Quite a few readers have been asking about it, and […]
[ed note: Michael Jorrin, aka “Doc Gumshoe,” is a medical writer (not a doctor) who shares his thoughts with us once or twice a month. As with all our guest authors, his words and opinions are his own] The stream – or should I say “torrent” – of medical and health-care related news doesn’t seem […]
[ed note: This is another installment from our favorite medical writer, Doc Gumshoe (no, he’s not a doctor, but we like the way he analyzes and explains medical issues for our readers). Since he’s talking about specific companies this time, we’ve restricted the piece to the Irregulars and have inserted some comments about the stocks […]
[Ed. note: Michael Jorrin, who we like to call “Doc Gumshoe,” is not a doctor, he is a longtime medical writer who contributes pieces for us that we hope give a good background or perspective on medical issues (and marketing) for those of us who are as overwhelmed with “live to 150” promises as we […]
I always feel a swell of optimism when I read a teaser ad from Patrick Cox — something about his relentless happy-facing about the teensy tiny technology and biotech companies he loves just stirs me up a little bit, reminds me that the reason many of us dabble in microcap stocks, little mining companies, new […]
Comments
ACW.asx Actinogen presents latest Xanamem data at AD Conference https://actinogen.com.au/asx-announcements/ Above is l...
$INND Innerscope Hearing Technologies, Inc. Good to hear from you Wfuiii. I've nibbled again. There will be further...
$INND Innerscope Hearing Technologies, Inc. https://www.innd.com/ MarkeTrak 10: Hearing Aids in an Era of Disruption ...
https://assets.boardroom.media/company_logo/ccdd47bd-38a1-4648-a771-398f23d727eb.jpg $ACW.asx Actinogen Medical > ...
Thank you Michael for this refresher, update and all your very informative articles. Announced this article on Twitter...
The two leading world experts on Alzheimers are Dr Dale Bredesden who has written a book entitled 'The End of Alzheimers...
This was immensely interesting as my mother has Alzheimer’s. You do not mention anywhere the research carried out by D...
Prevention is much more effective that treatment. Other measures include exercise, eating little or no sugar and doing m...
Four years ago, we returned to our retirement home, purchased over 40 years previously. Going to greet our neighbors, w...
Please look at Anavex Life Sciences: AVXL as I believe that they are on the right track with their A2-73 drug candidate ...
You might want to have a look at AVXL. From today's MT Newswires: "07:42 AM EDT, 10/02/2019 (MT Newswires) -- Anavex Li...
Virtual reality can spot navigation problems in early Alzheimer's disease by University of Cambridge https://medicalxpr...
Fred, sorry I missed your comment on L-serine. Have you found another source that taste's ok/better? I have not found...
Another failure in Alzheimer's Disease trials... BIIB and Eisai discontinued their late Phase 3 trials because they were...
This is a business there will he sales nonsense and I looked before I bought in bought in about their opt out policy. Th...
What is Ray Blonco's "Alzheimer’s Disease cure" 4olbear....
Anybody with experience using L-serine for preventative for ALS Alzheimers?; I can not find on retail market. I read an...
There may be something behind this. A 2017 book "The End of Alzheimer's..." published by Penguin/Random House, written b...
#86AD > Mandelblatt cautioned that her study was still too small to reach any conclusion, but if future studies could re...
I hope it works well for you, and that their drug is both effective and profitable. I've gotten very skeptical about Al...
Hello Doc, All, I have hesitated to mention this company involved in this field, but since we are on a common thread, na...
Many interesting comments in response to that Alzheimer’s piece. I’ll try to respond to as many as I can. And ma...
Hi Doc. What do you think about ANAVEX ? They are starting a phase 3 and here are the recent bullets. One huge positive ...
What does running do to your #brain? https://pbs.twimg.com/media/DhHfG2ZWAAYz_xC.jpg ty https://twitter.com/LEAD_C...
New development in 3-D super-resolution imaging gives insight on Alzheimer's disease https://phys.org/news/2018-07-d-su...
$AXSM > Bid 204K at $3.05 Axsome Therapeutics Announces AXS-05 Presentation at the 2018 Alzheimer's Association Interna...
Yet More Evidence that Viruses May Cause Alzheimer's Disease https://gizmodo.com/yet-more-evidence-that-viruses-may-cau...
Excitement about Alzheimer's drugs sometimes spurs big movements in Phase 1 and 2, though so far almost all of them have...
I'm trying to assess the opportunity for an investment in Promis Neurosciences. They are a pre-clinical stage biotech co...
$VTVT np - vTv Therapeutics Inc. has added a news release to its Investor Relations website. Title: vTv Therapeutics ...
$VTVT np - vTv Therapeutics Announces Topline Results from the First STEADFAST Phase 3 Study Evaluating Azeliragon in Pe...
See research at Paul H. Duray Pathology Research Fellowship that show borrelia burgdorferi aka Lyme disease spirochetes ...
Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease https://www.nature.com/articles/s415...
$ORY.BME - Oryzon to present at upcoming international conferences Madrid, Spain and Cambridge, MA - February 21st 20...
#AD - Arthritis drugs could halve the risk of Alzheimer's disease, study suggests http://www.telegraph.co.uk/news/2018/...
#AD - PMN.to NP - As someone who lost their father to alzheimer's disease, I did a fair bit of research into this compan...
$CWBR #MDPs New research article published in the journal of Alzheimer’s and Dementia supports a mitochondria(MDP)-b...
#AD #Tunes Another joy to parents/patients with Alzheimer's Disease is playing/listening to their favorite #music. Some...
Yep, there is a very wide gulf separating "Alzheimer’s Disease is Now Completely Treatable”" and "could give hope to...
#Alzheimer's Disease $CWBR Article: Dementia Shown Associated with Synaptic Dysfunction Rather Than Synaptic Loss GEN N...
Question of the week Maybe a bit of a trick question? My quick research says that the answer is HDV. It also says t...
NTRP-NP. Looking for $6.55 ( untested low) for SP. I am surprised that there hasn't been more interest in this outfit. R...
$AXSM UW Axsome announces recommendations to continue COAST-1, discontinue CREATE-1 trial Axsome Therapeutics an...
#Alzheimers Disease $Biogen$Merck$J&J$Denali Nice summary article in WSJ "Drug Industry Isn't Giving Up On Alzheimer's" ...
TRAVIS, LYNN, #ZKSS one in Moderation replaced by this one... #Alzheimer's #Disease #AD… The Neuroscience Inno...
$NTRP np - https://www.morningstar.com/news/pr-news-wire/PRNews_20171219NY73157/neurotrope-to-present-additional-findin...
$NTRP (long) [Post-hoc subgroup analysis of Phase 2 patients, completed May 2016, shows that Bryostatin had an appare...
$PFE Pfizer Ends Hunt for Drugs to Treat Alzheimer’s and Parkinson’s - About 300 layoffs to take place after once...
$Alzheimer Hi John, scary indeed. Last I heard the role of tau-phosphorylation in the pathogenesis of Alzheimers Dis...
$Alzheimers $AD (A great read of new research findings) Alzheimer’s protein may spread like an infection, human...
#Alzheimer'sDisease - Healthy mitochondria could stop Alzheimer's Date: December 6, 2017 Source: Ecole Polytechnique F...
#Alzheimer's Disease related - How Loneliness Affects Our Health https://www.nytimes.com/2017/12/11/well/mind/how-lonel...
Grief is convoluted but does have two "messy" phases: LOSS -as you plunge into a pit of pain and confusion, and then, ...
#Alzheimer's Disease related - http://fortune.com/2017/12/01/human-longevity-dna-ceo-out/...
#Alzheimer’s Disease Protective Alzheimer’s Gene Variant Uncovered ---> Linkage, whole genome sequence, and biologi...
#Alzheimer's Disease Protective Alzheimer's Gene Variant Uncovered https://genomemedicine.biomedcentral.com/articles/10....
Michael Jorrin - This was posted on the ihub message board this morning. This is too lengthy for your comment section bu...
My research into Alzheimer’s potential “cures” or drugs that do not attack the disease from the amyloid plaque ang...
What do you think about "Anavex Life Sciences Says Study of ANAVEX2-73 Shows Improvement in Alzheimer's Disease Patients...
Are you aware of the work by Dr Dale Bredesen? Here is a summary of that work as reported by Dr Mercola on his website:...
$ AXSM NP : (AXSM) More News 08-Nov-2017:07:00:00, Axsome Therapeutics Reports Third Quarter 2017 Financial R...
$Anti-aging $Mitochondria (?) An exciting new research report from NATURE (11/1) “Infusions of young blood tes...
$AXON np #FAIL Announces Negative Topline Results of Intepirdine Phase 3 MINDSET Trial in Alzheimer's Disease http:/...
$AXON -- I wish I had the guts to short this. Interesting piece on Alzheimers but doc is embargoed 'til December. Long-...
#Alzheimer's_Disease - $BIIB - Biogen Reports New Data from Phase 1b Study of Investigational Alzheimer’s Disease Trea...
#Alzheimers _Hypothesis “Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease.” St...
#Alzheimers _Hypothesis “Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer’s Disease.” St...
$Alzheimers $Hypothesis "Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease." Sternb...
I wrote today about a different Alzheimer's Disease drug being tested in mice, not the one Doc Gumshoe mentioned. It als...
$AXSM long - Prognosticating report and update tomorrow, Aug 9th, as that was the date last year. http://finviz.com/qu...
Molecular link between post-traumatic stress disorder and Alzheimer's disease https://medicalxpress.com/news/2017-08-m...
Interesting article. This seems to support the positive affect of Doxycycline for AD as it passes the BBB easily. A tria...
$NTRP Neurotrope Presents Phase 2 Data Assessing Bryostatin-1 in Moderate-to-Severe Alzheimer's Patients at AAIC 201...
$AXSM long - Title: Axsome Therapeutics Initiates Phase 2/3 Trial of AXS-05 for Alzheimer's Disease Agitation http://...
$Diabetes $Obesity $Alzheimers Disease "Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disea...
Scientists uncover the structure of tau filaments from Alzheimer’s disease https://medicalxpress.com/news/2017-07-atom...
Scientists uncover the structure of tau filaments from Alzheimer's disease https://medicalxpress.com/news/2017-07-atomic...
$CUR np - Neurotrope to Present Bryostatin Phase 2 Data in an Oral Presentation at AAIC 2017 Meeting NEW YORK - June 29...
#Alzheimer's Prevention - interesting new findings published in Medscape "Olive Oil Key Ingredient in Alzheimer's Pre...
#Alzheimer's Prevention - interesting new findings published in Medscape "Olive Oil Key Ingredient in Alzheimer's Pre...
#Alzheimer's Prevention - interesting new findings published in Medscape "Olive Oil Key Ingredient in Alzheimer's Pre...
I think folks have tired of the constant promise -- AVXL has been pitched as an "Alzheimer's Cure" company for almost a ...
$EBIX long and OW (but not like $AUPH!) This is the stock that got away from the Fool. I can't believe they never res...
They'd certainly like to believe they are. Anavex's drugs have been overpromised so many times over the years that I gr...
No $ticker. For those who have loved ones suffering from Alzheimer’s Disease, as I do, perhaps this is an alternative ...
Where to I go for Number 3. 3.A weird-looking mushroom from Europe that can REVERSE the effects of Alzheimer’s Disease...
$AXSM - Axsome Therapeutics Receives FDA Fast Track Designation for AXS-05 for Alzheimer's Disease Agitation Globe News...
$NTRP: Neurotrope Alzheimer's Trial Shows Top Line Efficacy in Hardest to Treat Patients Accesswire May 2, 201 Re...
$NTRP phew! glad you posted that Dr KSS. It's down pre-mkt but coming nicely off the bottom since you posted. Neurotr...
$NTRP Long Neurotrope Bioscience to Release Results From Phase 2 Clinical Trial in Moderate to Severe Alzheimer's Disea...
$AXSM: Initial AXS-02 Phase 3 trial data readout expected in 4Q17. AXS-02 is in Phase 3 development with Fast Track stat...
$TDSGF - 3D Signatures’ TeloView™ Software Identifies and Stages Patients With Alzheimer’s Disease From a Cheek Sw...
Interesting and well written article. Thank you. It's particularly disturbing how little progress modern medicine has ...
I heard back from the Alzheimer’s foundation I donate to about the bexarotene study: "To summarize the results from wh...
Sometime back I was reading an article which mentioned an executive (can't remember the name) who had previously been at...
$NTRP The market does not seem too excited by the news out today, no change in stock price. I recall there are at least ...
Myron are you seriously calling Alzheimer's Disease a "lifestyle disease" caused by a lousy diet?? You claim that folk ...
Layman's article: THE NEW OFFENSIVE ON ALZHEIMER’S DISEASE: STOP IT BEFORE IT STARTS http://www.newsweek.com/2017/...
$NTRP (long) I just wanted to point out that there was a corporate presentation today, which included a discussion (by ...