DR. KSS LOOKS AT A COMPANY TACKLING HEPATITIS B
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36 diseases not caused by virus or bacteria have had exponential increases since the start of the digital age. One of t...
I am aware of only one (1) instance when enough vitamin C was used in a study by the Orthodoxy to show a meaningful ef...
I hope you are aware that the first Polio vaccine was outlawed in multiple states (of USA) because it caused so much Pol...
There is plenty to fear from all sides in this argument. The inherent deception being put upon the general public is ver...
$APTO (FP) 6/4/18 SEC form 6K FILING -- Very positive news, but as of noon today it has not affected the share price...
Oops. Wrong on two counts: 1) microwaves are part of the electromagnetic spectrum, not sound; and 2) Most cancers are n...
$CWBRI saw this interesting study yesterday but was unsure of the source. Evidently the editors of the APA online n...
Decades ago you may have read (published once in NY Times) that NIH found high levels of ascorbic acid caused Apoptosis ...
Hi LostOkie: Thanks for your post and query. A good discussion. Sort of as is the case with most stocks in biotech, I'm ...
$AMBS SORRY everyone. Long post here. Hi Dr. KSS. If you don't mind, I'd like to have your opinion on something? I've ...
$FATE long, $APTO xxOWxx and $HTBX long, post in MODERATION, please release. Thank YOU!PRESENTATION Aptose Bioscie...
$APTO longSAN DIEGO and TORONTO, Dec. 11, 2017 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. (APTO) (APS.TO) today ann...
$apto ow $blph ow $SRRA ow my top three horsemen holdings for that proverbial greek island. $apto huge move after Dr KS...
$THIS and $THAT $WEED.TO, $POT, $MJ $TRPX np :)Abstract:Cannabinoid receptors type 1 (CB1) and type 2 (CB2) ha...
$APTO has delivered multiple abstracts to ASH, and will present 3 in poster form. The remaining, including 2 on APTO-253...
$APTO lONG01-Nov-2017:11:14:00, Aptose to Present New CG806 Data at the 2017 ASH Annual MeetingSAN DIEGO and T...
Tacro promotes apoptosis of beta-cells in islets. Differential NFATc signalling voclo vs tacro. alters insulin elaborati...
APTO-253 induces apoptosis in about a third of AML cells but not all.I'm a bit surprised by palaver in other posts ...
$APTO, long, the lead agent from APTO induces apoptosis (programmatic suicide) in acute myeloid leukemia (AML) cells. T...
One of my favorite scenes. "Time to die" Immediately made me think of DrKSS's Oncotutorial and the discussion of apoptos...
A study that does more for $ARWR than for HBV patients, the intended target. http://stm.sciencemag.org/content/9/409/eaa...
$APTOThe following article is highly relevant to Aptose whose lead assets, one of the two, is an FLT3/BTK dual inhib...
Pulse Biosciences (PLSE) is much more than a dermatology play. Pulse uses nanosecond pulses to trigger apoptosis in cel...
Thanks for the great article.I'd like to venture some guesses on the thought experiments. The first, regarding colo...
There has been a glioblastoma multiforma that was held in remission for 5 years, using a low-temperature water extract o...
Sierra Oncology (SRRA) - cancer cells are pretty unstable. Better than Tesaro's drug at apoptosis of cancer cells withou...
Yes, I'd not seen the video...it apparently was released today, no?---but had already alluded to it in a draft of a colu...
#GlaucomaRetinal ganglion cells die from apoptosis in glaucoma. You can usually tell from examination that someone is...
Let me take a real-world clinical example that teaches us how you have to interpret all this telomere data with great gr...
Some immuno-fibotic morsels for those so inclined. Hope you all have had a recuperative weekend.1) Activated hep...
Hi Everyone, using Synthetic Hypercin for Cutaneuos T-Cell Lymphoma topical Rx. SGX-301 a phase 3 study currently Sollig...
Well THIS certainly rekindles debate: https://www.ncbi.nlm.nih.gov/pubmed/28148715?dopt=Abstract&utm_source=dlvr.it&...
It restores apoptosis by acting on bcl-2 function in CLL. We covered the development of this agent in the threads in 201...
lump, Doc also has high expectations for $APTO -- "$APTO’s lead agent is an apoptosis restorer now demonstrated to hav...
$ITEK npGreat question.The higher than usual starting IOP inclusion criteria for both MATrX-1 and MATrX-2 is a r...
It's hard to know here. The problem is that the toxicity concerns that felled birinapant were ones where the drug was be...
Two or three years ago I bought into a bio stock which is up at one point today 284%. Pretty good?? $TLOGTetraLogi...
Hi Jyoung007: Thanks for your kind words. I apologize for not getting back to you sooner...was distracted by the festive...
You? You're super-cool! Why would I be irked at you?You're right....ugly ducklings can become beautiful swans in Man...
No, pracinostat from $MEIP is an epigenetic modifier of transcription/translation, while the lead agent from Apto induce...
STM: For one thing, the mechanisms of apoptosis are extremely intricate, and working all of them out is a work in progre...
Twelve more? Oi! This one seems a little early to me--not even started P2, so plenty of time to watch from a distance. A...
I have to admit it may have been overpriced a little at its former peak. But a company trading for THIS pennies-a-servin...
Thanks Doc, what a cool idea with The Twelve Biotech's of Christmas . In the video Apoptosis kicked some arse. Some heft...
Watch this video first. It's a video of necrosis. Necrosis is what old-fashioned cancer treatment causes your cells to d...
This is for allisondbl and others interested in BioLineRx.Recall that our original interest in this US listed Israel...
Thanks, Doc. Have a safe westward passage. Looking forward to hearing of apoptosis redux.$BLRX long...
Thanks Mary Ellen! Getting ready to turn my general vector of peregrination westward and home.ALthough I no longer h...
One gets into a real quandary about how to regard this company as an investment. On the one hand, we once were favorable...
My point would be that since testing stratification was done with Opdivo in which it was test-driven using tumor situati...
To eyedoc and others: I wanted to bring a little more color to how I chose between $BMY and $MRK on the basis of their c...
JohnM: Cells become cancerified because the cells' DNA mutates, allowing it to multiply with abandon, escape the immune ...
Good morning, Doc. Just finishing the second cup of my dark roast Kona coffee out here on the left coast. I hope you are...
Very interesting, Ben. Synthetic lethality seems (at first look, anyway) as if it could be a major tool in the search fo...
$KPTI - Karyopharm Publishes Preclinical Data in Nature Demonstrating Selinexor's Potential in KRAS-Mutant Non-Small Cel...
Hi Tom: What's happening, I feel, is a pre-ASH reflation trade for $KPTI. This tends to happen right at this time of yea...
$KPTI - Karyopharm Announces Phase 1b Selinexor Sarcoma Data Published in Journal of Clinical OncologyData Provide E...
Answer to the Question of the Day for 25 July 2016.The correct answers to this question come from a classic paper, w...
Dr. KSSI believe this is the NEJM article referred to:A Trial of Calcium and Vitamin D for the Prevention of Col...
$RGLS Jaundice is indication of bilirubin in blood perhaps from apoptosis.http://www.aafp.org/afp/2004/0115/p299....
$VBLT is VBL Technologies, formerly Vascular Biogenics, an Israeli firm. I took a position because I was impressed with ...
Thanks, Noci, a million for finding this. Cause for great optimism! Selinexor has been racking up toxicity issues of bad...
More on $DNAI: I can't exclude the possibility of a ASCO pop here: by most measures, the company is a little undervalued...
My congratulations to AbbVie for garnering FDA approval for its new oral CLL agent.Periodically we discuss modes of ...
Hard for me to see it holding this. It's way way overvalued now. This is a reformulation of 2 main drugs for AML, and wi...
$TRXC-Hi Katerina (btw-I love your new avatar :-) ) You now own less of the pie. If the pie is as small as a human cell...
And you trust Roth? Roth Capital's New Buy Rating On TetraLogic: 'SMAC'ing Cancer Around' 8:30 am ET December 31, 2015...
I still have a $KPTI position, but it's a starter one, and ardor has cooled all around for this stock. I do think their ...
Thanks for the reply. My main point is not really the apoptosis vs necrosis debate... it's the statistical significance ...
With all due respect to KSS, and I am thoroughly impressed with his research on SPHS and ZFGN, among other things, I wou...
Interesting points. I have to say I am still not persuaded it's necrosis regardless of what a publication said because: ...
Interesting points. I have to say I am still not persuaded it's necrosis regardless of what a publication said because: ...
gambly Ok lets accept that necrosis is caused by enzymic activity much as burning,stopping blood flow or corrosion would...
Here's the link to PRX causing necrosis and not apoptosis: http://c953383.r83.cf2.rackcdn.com/file_attachment/attachmen...
Fair enough. Thanks for your thoughts. However, it actually works according to necrosis, not apoptosis, according to the...
My personal feeling about $SPHS is that the phase 3 trial is pretty much doomed as regards its second, final endpoint. T...
Hi....the weird thing about Carter's case is that his primary is unknown. Occasionally, very rarely, melanomatous lesion...
Frank: personally I would hold but not add. I don't think the drug is kaput, but we need more data from them. I think I ...
I, too, am pretty worried. I hedge on throwing in the towel here for the main reason that when adversity strikes like th...
$KPTI is ready to begin recruiting for what may be the most important trial to date for it: https://clinicaltrials.gov/...
From SA: Luspatercept Fast Track'd for beta thalassemiaThe FDA designates luspatercept for Fast Track review for th...
A small triumph for Taiho Oncology, not yet traded on the US market, with this study appearing in NEJM: http://www.nejm....
TLOG I have been trying to find out about the clinical hold placed on the hepatitis B trial on Birinapant. "Cranial Ne...
Agree. I am hoping for good data from them. The newer agent they are alluding to would place MEI Pharma rather squarely ...
Jack, John,Vicki, I had asked Doc about this one back earlier in the year because it had perked my interest as well.Here...
$TLOG: Merck (NYSE:MRK) and TetraLogic Pharmaceuticals (NASDAQ:TLOG) will collaborate on a Phase 1 study to evaluate th...
KPTI-Karyopharm Granted U.S. Composition-of-Matter Patent for Selinexor (KPT-330) First-in-Class Oral SINE(TM) XPO1 Inh...
Hi Les....sorry...this has been a frantic week for me and I am behind on many things including reading posts. People may...
Dr.KSS, I am unable to track down the exact publication by Roger Newton's group that would be most pertinent--will sea...
DR.KSS, In view of all the speculation on this board of Esperion being bought out or just its compound ETC-1002 (Bemp...
Needham lowers price target on TetraLogic $TLOG from $16 to $10. I know of nothing objective driving this change, and do...
I was in no way advocating the increased use of glucose,,,merely pointing out the impossibility of not having it in your...
This is too good to be true but if it is the cost of cancer drugs will nose-dive. http://tinyurl.com/ogrmgwd Summary: ...
Allison and others....one of the more interesting things about inflammatory bowel disease still has to be how we are jus...
Vijay, you DA man! Look at this! Got screaming red hot biotechs coming out your eyeballs.....and it looks good! Amazing!...
Frenchy: A great post. This is a good way in which to take Irregulars behind the scenes, however, in that I want to show...
Joe: it's a DNA inhibition play, roughly along lines of RNAi.Bcl-2 is a gene whose product, in B-lymphocytes, blocks...
It's been a while since I have looked in on it, and imetelstat has had some controversy. Let me look into it. May be ton...
To Joe Schelble: about Curis($CRIS). I could see this one running another 20- 25 percent from here over the near term. W...