Topic Archives: apoptosis

[Ed. Note: Dr. KSS writes about medicine and biotech stocks for the Irregulars. His words and opinions are his own, and he has agreed to our trading restrictions.] Want to see something really cool? A hot video clip from a steamy biotech thriller? Watch this. Better yet, when you pull up the video viewing frame, […]

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    I hope you are aware that the first Polio vaccine was outlawed in multiple states (of USA) because it caused so much Pol...

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    There is plenty to fear from all sides in this argument. The inherent deception being put upon the general public is ver...

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    $APTO (FP) 6/4/18 SEC form 6K FILING -- Very positive news, but as of noon today it has not affected the share price...

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    Oops. Wrong on two counts: 1) microwaves are part of the electromagnetic spectrum, not sound; and 2) Most cancers are n...

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    $CWBR I saw this interesting study yesterday but was unsure of the source. Evidently the editors of the APA online n...

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    Decades ago you may have read (published once in NY Times) that NIH found high levels of ascorbic acid caused Apoptosis ...

  • Dr. KSS MD PhD

    Hi LostOkie: Thanks for your post and query. A good discussion. Sort of as is the case with most stocks in biotech, I'm ...

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    $AMBS SORRY everyone. Long post here. Hi Dr. KSS. If you don't mind, I'd like to have your opinion on something? I've ...

  • SoGiAm

    $FATE long, $APTO xxOWxx and $HTBX long, post in MODERATION, please release. Thank YOU! PRESENTATION Aptose Bioscie...

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    $APTO long SAN DIEGO and TORONTO, Dec. 11, 2017 (GLOBE NEWSWIRE) -- Aptose Biosciences Inc. (APTO) (APS.TO) today ann...

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    $apto ow $blph ow $SRRA ow my top three horsemen holdings for that proverbial greek island. $apto huge move after Dr KS...

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    $THIS and $THAT $WEED.TO, $POT, $MJ $TRPX np :) Abstract: Cannabinoid receptors type 1 (CB1) and type 2 (CB2) ha...

  • Dr. KSS MD PhD

    $APTO has delivered multiple abstracts to ASH, and will present 3 in poster form. The remaining, including 2 on APTO-253...

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    $APTO lONG 01-Nov-2017:11:14:00, Aptose to Present New CG806 Data at the 2017 ASH Annual Meeting SAN DIEGO and T...

  • Dr. KSS MD PhD

    Tacro promotes apoptosis of beta-cells in islets. Differential NFATc signalling voclo vs tacro. alters insulin elaborati...

  • Dr. KSS MD PhD

    APTO-253 induces apoptosis in about a third of AML cells but not all. I'm a bit surprised by palaver in other posts ...

  • JohnM

    $APTO, long, the lead agent from APTO induces apoptosis (programmatic suicide) in acute myeloid leukemia (AML) cells. T...

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    One of my favorite scenes. "Time to die" Immediately made me think of DrKSS's Oncotutorial and the discussion of apoptos...

  • SoGiAm

    A study that does more for $ARWR than for HBV patients, the intended target. http://stm.sciencemag.org/content/9/409/eaa...

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    $APTO The following article is highly relevant to Aptose whose lead assets, one of the two, is an FLT3/BTK dual inhib...

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    Pulse Biosciences (PLSE) is much more than a dermatology play. Pulse uses nanosecond pulses to trigger apoptosis in cel...

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    Thanks for the great article. I'd like to venture some guesses on the thought experiments. The first, regarding colo...

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    There has been a glioblastoma multiforma that was held in remission for 5 years, using a low-temperature water extract o...

  • JohnM

    Sierra Oncology (SRRA) - cancer cells are pretty unstable. Better than Tesaro's drug at apoptosis of cancer cells withou...

  • Dr. KSS MD PhD

    Yes, I'd not seen the video...it apparently was released today, no?---but had already alluded to it in a draft of a colu...

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    #Glaucoma Retinal ganglion cells die from apoptosis in glaucoma. You can usually tell from examination that someone is...

  • Dr. KSS MD PhD

    Let me take a real-world clinical example that teaches us how you have to interpret all this telomere data with great gr...

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    Some immuno-fibotic morsels for those so inclined. Hope you all have had a recuperative weekend. 1) Activated hep...

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    Hi Everyone, using Synthetic Hypercin for Cutaneuos T-Cell Lymphoma topical Rx. SGX-301 a phase 3 study currently Sollig...

  • Dr. KSS MD PhD

    Well THIS certainly rekindles debate: https://www.ncbi.nlm.nih.gov/pubmed/28148715?dopt=Abstract&utm_source=dlvr.it&...

  • Dr. KSS MD PhD

    It restores apoptosis by acting on bcl-2 function in CLL. We covered the development of this agent in the threads in 201...

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    lump, Doc also has high expectations for $APTO -- "$APTO’s lead agent is an apoptosis restorer now demonstrated to hav...

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    $ITEK np Great question. The higher than usual starting IOP inclusion criteria for both MATrX-1 and MATrX-2 is a r...

  • Dr. KSS MD PhD

    It's hard to know here. The problem is that the toxicity concerns that felled birinapant were ones where the drug was be...

  • arch1

    Two or three years ago I bought into a bio stock which is up at one point today 284%. Pretty good?? $TLOG TetraLogi...

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    Hi Jyoung007: Thanks for your kind words. I apologize for not getting back to you sooner...was distracted by the festive...

  • Dr. KSS MD PhD

    You? You're super-cool! Why would I be irked at you? You're right....ugly ducklings can become beautiful swans in Man...

  • Dr. KSS MD PhD

    No, pracinostat from $MEIP is an epigenetic modifier of transcription/translation, while the lead agent from Apto induce...

  • Dr. KSS MD PhD

    STM: For one thing, the mechanisms of apoptosis are extremely intricate, and working all of them out is a work in progre...

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    Twelve more? Oi! This one seems a little early to me--not even started P2, so plenty of time to watch from a distance. A...

  • Dr. KSS MD PhD

    I have to admit it may have been overpriced a little at its former peak. But a company trading for THIS pennies-a-servin...

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    Thanks Doc, what a cool idea with The Twelve Biotech's of Christmas . In the video Apoptosis kicked some arse. Some heft...

  • Dr. KSS MD PhD

    Watch this video first. It's a video of necrosis. Necrosis is what old-fashioned cancer treatment causes your cells to d...

  • Dr. KSS MD PhD

    This is for allisondbl and others interested in BioLineRx. Recall that our original interest in this US listed Israel...

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    Thanks, Doc. Have a safe westward passage. Looking forward to hearing of apoptosis redux. $BLRX long...

  • Dr. KSS MD PhD

    Thanks Mary Ellen! Getting ready to turn my general vector of peregrination westward and home. ALthough I no longer h...

  • Dr. KSS MD PhD

    One gets into a real quandary about how to regard this company as an investment. On the one hand, we once were favorable...

  • Dr. KSS MD PhD

    My point would be that since testing stratification was done with Opdivo in which it was test-driven using tumor situati...

  • Dr. KSS MD PhD

    To eyedoc and others: I wanted to bring a little more color to how I chose between $BMY and $MRK on the basis of their c...

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    JohnM: Cells become cancerified because the cells' DNA mutates, allowing it to multiply with abandon, escape the immune ...

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    Good morning, Doc. Just finishing the second cup of my dark roast Kona coffee out here on the left coast. I hope you are...

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    Very interesting, Ben. Synthetic lethality seems (at first look, anyway) as if it could be a major tool in the search fo...

  • SoGiAm

    $KPTI - Karyopharm Publishes Preclinical Data in Nature Demonstrating Selinexor's Potential in KRAS-Mutant Non-Small Cel...

  • Dr. KSS MD PhD

    Hi Tom: What's happening, I feel, is a pre-ASH reflation trade for $KPTI. This tends to happen right at this time of yea...

  • SoGiAm

    $KPTI - Karyopharm Announces Phase 1b Selinexor Sarcoma Data Published in Journal of Clinical Oncology Data Provide E...

  • Dr. KSS MD PhD

    Answer to the Question of the Day for 25 July 2016. The correct answers to this question come from a classic paper, w...

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    Dr. KSS I believe this is the NEJM article referred to: A Trial of Calcium and Vitamin D for the Prevention of Col...

  • arch1

    $RGLS Jaundice is indication of bilirubin in blood perhaps from apoptosis. http://www.aafp.org/afp/2004/0115/p299....

  • Dr. KSS MD PhD

    $VBLT is VBL Technologies, formerly Vascular Biogenics, an Israeli firm. I took a position because I was impressed with ...

  • Dr. KSS MD PhD

    Thanks, Noci, a million for finding this. Cause for great optimism! Selinexor has been racking up toxicity issues of bad...

  • Dr. KSS MD PhD

    More on $DNAI: I can't exclude the possibility of a ASCO pop here: by most measures, the company is a little undervalued...

  • Dr. KSS MD PhD

    My congratulations to AbbVie for garnering FDA approval for its new oral CLL agent. Periodically we discuss modes of ...

  • Dr. KSS MD PhD

    Hard for me to see it holding this. It's way way overvalued now. This is a reformulation of 2 main drugs for AML, and wi...

  • sogiam

    $TRXC-Hi Katerina (btw-I love your new avatar :-) ) You now own less of the pie. If the pie is as small as a human cell...

  • sogiam

    And you trust Roth? Roth Capital's New Buy Rating On TetraLogic: 'SMAC'ing Cancer Around' 8:30 am ET December 31, 2015...

  • Dr. KSS MD PhD

    I still have a $KPTI position, but it's a starter one, and ardor has cooled all around for this stock. I do think their ...

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    Thanks for the reply. My main point is not really the apoptosis vs necrosis debate... it's the statistical significance ...

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    With all due respect to KSS, and I am thoroughly impressed with his research on SPHS and ZFGN, among other things, I wou...

  • Dr. KSS MD PhD

    Interesting points. I have to say I am still not persuaded it's necrosis regardless of what a publication said because: ...

  • Dr. KSS MD PhD

    Interesting points. I have to say I am still not persuaded it's necrosis regardless of what a publication said because: ...

  • arch1

    gambly Ok lets accept that necrosis is caused by enzymic activity much as burning,stopping blood flow or corrosion would...

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    Here's the link to PRX causing necrosis and not apoptosis: http://c953383.r83.cf2.rackcdn.com/file_attachment/attachmen...

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    Fair enough. Thanks for your thoughts. However, it actually works according to necrosis, not apoptosis, according to the...

  • Dr. KSS MD PhD

    My personal feeling about $SPHS is that the phase 3 trial is pretty much doomed as regards its second, final endpoint. T...

  • Dr. KSS, MD PhD

    Hi....the weird thing about Carter's case is that his primary is unknown. Occasionally, very rarely, melanomatous lesion...

  • Dr. KSS, MD PhD

    Frank: personally I would hold but not add. I don't think the drug is kaput, but we need more data from them. I think I ...

  • Dr. KSS, MD PhD

    I, too, am pretty worried. I hedge on throwing in the towel here for the main reason that when adversity strikes like th...

  • Dr. KSS, MD PhD

    $KPTI is ready to begin recruiting for what may be the most important trial to date for it: https://clinicaltrials.gov/...

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    From SA: Luspatercept Fast Track'd for beta thalassemia The FDA designates luspatercept for Fast Track review for th...

  • Dr. KSS, MD PhD

    A small triumph for Taiho Oncology, not yet traded on the US market, with this study appearing in NEJM: http://www.nejm....

  • DBMD

    TLOG I have been trying to find out about the clinical hold placed on the hepatitis B trial on Birinapant. "Cranial Ne...

  • Dr. KSS, MD PhD

    Agree. I am hoping for good data from them. The newer agent they are alluding to would place MEI Pharma rather squarely ...

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    Jack, John,Vicki, I had asked Doc about this one back earlier in the year because it had perked my interest as well.Here...

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    $TLOG: Merck (NYSE:MRK) and TetraLogic Pharmaceuticals (NASDAQ:TLOG) will collaborate on a Phase 1 study to evaluate th...

  • sogiam

    HN - LOL :-) Re: Having enough trouble learning about lymphocytic phageotic apoptosis, don’t need to learn about ran...

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    I am grateful a new blog is better. I'm not going to referee it though. Having enough trouble learning about lymphoc...

  • sogiam

    KPTI-Karyopharm Granted U.S. Composition-of-Matter Patent for Selinexor (KPT-330) First-in-Class Oral SINE(TM) XPO1 Inh...

  • Dr. KSS, MD PhD

    Hi Les....sorry...this has been a frantic week for me and I am behind on many things including reading posts. People may...

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    Dr.KSS, I am unable to track down the exact publication by Roger Newton's group that would be most pertinent--will sea...

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    DR.KSS, In view of all the speculation on this board of Esperion being bought out or just its compound ETC-1002 (Bemp...

  • Dr. KSS, MD PhD

    Needham lowers price target on TetraLogic $TLOG from $16 to $10. I know of nothing objective driving this change, and do...

  • arch1

    I was in no way advocating the increased use of glucose,,,merely pointing out the impossibility of not having it in your...

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    This is too good to be true but if it is the cost of cancer drugs will nose-dive. http://tinyurl.com/ogrmgwd Summary: ...

  • Dr. KSS, MD PhD

    Allison and others....one of the more interesting things about inflammatory bowel disease still has to be how we are jus...

  • Dr. KSS, MD PhD

    Vijay, you DA man! Look at this! Got screaming red hot biotechs coming out your eyeballs.....and it looks good! Amazing!...

  • Dr. KSS, MD PhD

    Frenchy: A great post. This is a good way in which to take Irregulars behind the scenes, however, in that I want to show...

  • Dr. KSS, MD PhD

    Joe: it's a DNA inhibition play, roughly along lines of RNAi. Bcl-2 is a gene whose product, in B-lymphocytes, blocks...

  • Dr. KSS, MD PhD

    It's been a while since I have looked in on it, and imetelstat has had some controversy. Let me look into it. May be ton...

  • Dr. KSS, MD PhD

    To Joe Schelble: about Curis($CRIS). I could see this one running another 20- 25 percent from here over the near term. W...

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