We haven’t looked at a biotech teaser pitch in a little while, so this one for a new Mauldin Economics newsletter caught my eye… Chris Wood is helming Healthy Returns, along with celebrity doctor Michael Roizen (now referred to as a “wellness guru” and head of the Wellness Institute at the Cleveland Clinic, he is […]
Doc Gumshoe is not in the habit of contradicting the conclusions, backed by research, that are stated in papers published by the Journal of the American Medical Association, commonly referred to as JAMA. JAMA is, after all, one of a handful of the most prestigious medical journals on the planet, along with the New […]
Ray Blanco seems to love pitching a good “results coming soon” story for his FDA Trader ($1,495, no refunds) newsletter over at Agora, and this one is no different from dozens of others he has touted in the past… though the stock is one I haven’t seen him tease before. OK, fine, yes, I know […]
The ads that get the most attention tend to be either those that are most dramatically distributed, with seemingly every single email address getting multiple copies… or those that come with a big promise and a very high price. Today’s topic of interest is the latter, since we’re told that Stansberry Venture Value’s Dave Lashmet […]
[Ed note: Here is our latest piece from “Doc Gumshoe”, who is a medical writer (not a doctor) who shares his wisdom with us at Stock Gumshoe a couple times a month. He does not typically write specifically about investments, but does write about publicly traded companies and their drugs, and has agreed to our trading […]
[ed note: Michael Jorrin is longtime medical writer who has been sharing his thoughts with our readers as “Doc Gumshoe” for several years (he’s not a doctor, I gave him the name). He generally covers medical and health news and sometimes health promotions and hype, but he rarely opines about investments or specific stocks. All […]
This article originally appeared on July 22, 2015, and the bulk of it has not been updated or revised since. The meat of the ad is essentially the same, and if Lichtenfeld really “bet his paycheck” on this stock (which was and is Alnylam) on July 22 he’s so far lost about 65% of that […]
[ed note: Michael Jorrin, who we like to call “Doc Gumshoe”, is a longtime medical writer (not a doctor) who writes non-investment articles about medicine and health topics for us once or twice a month. As with all of our guest contributors and columnists, he chooses his own topics and his words are his alone] […]
A Non-Statin Pill That Really Lowers Cholesterol, Blood Pressure and Inflammation without Side Effects Would be a Good Investment, Right?
[Ed. Note: Dr. KSS writes about medical topics and biotech stocks for the Irregulars. He has agreed to our trading restrictions, and his thoughts and words are his own. Enjoy!] Any discussion of cholesterol immediately turns Brobdingnagian, such are the extremes in question. Statins, which lower LDL cholesterol, are bombastically the best-selling drugs of all […]
Will PCSK9 Inhibitors Be the Next Blockbusters in Cardiovascular Disease?
[Ed note: Here is our latest piece from “Doc Gumshoe”, who is a medical writer (not a doctor) who shares his wisdom with us at Stock Gumshoe a couple times a month. As always, Michael’s words and opinions are his own.] Lots of analysts and prognosticators give these cholesterol-lowering agents a big thumbs up. The […]
The Statin Guidelines: Looking at the Whole Cardiovascular Spectrum
[ed. note: We feature the writings of Doc Gumshoe, our favorite medical scribe, every few weeks here at Stock Gumshoe. He is not a doctor, but we value his insight, research, contrariness and skepticism … and, most importantly, his ability to explain complex health issues for our readers. You can see all of Michael’s previous […]
Comments
Pharmageddon Forty years ago Ancel Keys2 sold the concept of the cholesterol etiology of cardiovascular disease, an...
It seems unfortunate that a discussion of eggs and cholesterol in so many instances has degenerated into what I can only...
Not only does dietary cholesterol account for only about 15% of total serum cholesterol, but I have read that another co...
I'm 88. My blood pressure measures in the range of 120/65 +/- 5; pulse usually around 60 except mornings ~55. Not diabet...
Hi Doc Gumshoe, I am an egg lover and statin hater of longstanding. For many years, when young I ate cereal product usu...
Eggs are nearly perfect food. The 'culprits' have been widely determined to be sugar (say, high glucose corn syrup), car...
I am 80 and get regular blood tests, have all necessary vaccines up to date, take simvastatin and have very good cholest...
I have no faith in the use of statins in treating cholesterol and many physicians feel the same way. There has always be...
Nice analysis Dr. G, but what about ALSO looking at why the body makes cholesterol in the steroid tree, and its complex ...
I think the egg debate is definitely inconclusive at this point. As a pathologist who has cut through calcified atherosc...
Learning that our bodies synthesize most of the cholesterol we use helped me realize that exercise is the controllable f...
The cholesterol story is on a par with man-made-warming. The former generates $50Bn in revenue thus funding volumes of s...
Thank you, Doc! My doctors have been bugging me to take statin drugs to lower my cholesterol levels and I cannot tolerat...
Excellent article. Heart disease runs in my family. My cholesterol was naturally high till I changed my diet. My fath...
Eat eggs every day with scrapple, ham or bacon. Statin keeps my cholesterol, under control. Every time I reduce my 2/d ...
The best way to fight alzheimers is a KETO diet ! brains need cholesterol ( cell making substance) KETO feeds brains ke...
Another "cover-up" of natural cures? After sitting through most of their video presentation, I opted for their book and ...
More evidence that cholesterol (LDL) has no effect on heart: https://www.irishtimes.com/news/health/no-evidence-high-...
Just a FYI for folks with a cholesterol problem. Some pharmaceuticals are a dangerous solution to a simple problem. AKA ...
I am so tired of being hyped. Although these type of ads have been a great and costly learning experience for me. The...
To all those that are saying that high cholesterol is not bad for you and does not cause heart disease you are wrong and...
Also research shows that once you are over 70 years old and have no history of heart disease those with higher cholester...
Due to inflammation reduction? KSS promoted this aspect, company seems to downplay it. Riding on the cholesterol fear ca...
My family typically lives into their 90's (previous 2 generations / both sides). I have high cholesterol, assume they di...
The above people who said statin drugs are a fraud perpetrated on the American people by Big Pharma are 100 percent corr...
I agree with you 100%. Forty five years ago I was diagnosed with high cholesterol (300 Total) and was put on statins th...
It will be a discovery of majestic proportions to discover a drug which is effective for dyslipidaemias - incorrect / el...
The better news is that we have been duped for about the last 50 years about what causes heart attacks and heart disease...
I was trying to figure this out myself, after doing a little research i think the ticker is ESPR.. @ $43/Share roughly.....
Ha, have to try that. Thanks Cleveland. See, that's the trouble with a lot of our society. Simple stuff that work...
STM, I claim no expertise. I couldn't use statins. I think $ESPR has an important niche. I don't believe that the man...
#ESPR Listened to the call this a.m. I understood deaths not related to ESPR. Many trial study participants are sick pe...
#ESPR 2 in moderation Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bemp...
$ESPR > Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bempedoic Acid ht...
I'm puzzled about the above comment that I supposedly made. I don't recall it, and certainly don't agree that the essay ...
Author: Roger I guess whether statins provide longevity remains an issue. I had muscle deterioration and problems with...
Lannas, at this moment, you're right. I didn't sell $ESPR. I guess whether statins provide longevity remains in issue....
$ESPR sp - (long no link) Esperion Announces Positive Top-Line Results from First Pivotal Phase 3 Study of Bempedoic Aci...
Variant Pharam was founded 2014 and is a Private company. Website: https://www.variantpharma.com/ Lead orphan drug...
Two very important things to consider are bad fats and sugar. Sugar causes glycation so the proteins don't work properl...
$NoTicker Speaking of cholesterol - Here is some fun and eyebrow raising work (N = not very many, yet), in which l...
$ESPR question for chartists: what support level are you seeing given the steady run-up until today? Decline today ...
$ESPR related sp - Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor http://www.cel...
$MDGL $ESPR MDGL Achieves Primary Endpoint in Patients with NASH. https://finance.yahoo.com/news/madrigal-mgl-3196-ac...
$KPTI np 8K Filed with the SEC http://investors.karyopharm.com/secfiling.cfm?filingid=1193125-17-358925&CIK=1503802 ...
i don't believe in the drugs prescribed by most doctors. I have read that former heads of the FDA pushed for acceptance ...
Thank you, Doc G. I appreciate the way you've identified trends in both causation and reduction, but also identified co...
$ESPR Esperion to Participate in Fireside Chat at the Jefferies 2017 London Healthcare Conference GlobeNewswire•No...
$CRISPR-Cas9 - Nanotech, gene editing used to edit cholesterol gene: U.S. study https://www.reuters.com/article/us-hea...
My personal suggestion is using this forum first for questions. People like Rice and Chow work very very hard, and if I ...
$AMYT. ralph, I’m not denying that you may be correct, since even the occasional Dr KSS recommendation has fallen by t...
I could not agree more with you Maryanne. Back in April, I ruptured my achilles tendon and was laid up at home for 3 mon...
$MRK $ESPR $CETP Barron's article: "Merck: Heartbreak over a cholesterol drug" In excerpts: In study data releas...
I agree on $ESPR. They are also actively looking for a partnership. $MRK might end up abandoning CETP and they dont want...
$ESPR (of high relevance) $MRK $CETP Merck hits a bloop single in an epic PhIII CETP cardio contest. Now what? (Endpo...
$PCSK9 $ESPR $AMGN New findings reported today at the ESC Congress: "PCSK9 Is A Co-Activator Of Platelet Function ...
$ESPR long - Prices at $49 - Esperion Prices Public Offering of Common Stock http://investor.esperion.com/releasedetai...
$ESPR np sold today at 53.00 Esperion Announces Proposed Public Offering of Common Stock 4:31 pm ET August 8, 2017 (Glo...
$ESPR - Esperion Announces Proposed Public Offering of Common Stock http://globenewswire.com/news-release/2017/08/08/10...
Hi: thanks for posting and asking. As regards Esperion, we still love the company, and it is one of multiple moving targ...
Eyedoc is right. I had a tempestuous dream last night that somehow I was being seen by a physician semi-against my wishe...
Hi Dr. KSS. I'd like to add my experiences with Metf0rmin. I've been taking metformin since 2007 at the urging of my ph...
And one more from biopharma drive: "This could either be due to lower than expected efficacy, adverse events seen in ...
Esperion shares may sputter this morning on new from $MRK that anacetrapib met primary study goals in a CVOT. I hope rea...
Glenn, tempest in a teapot really. Fewer than 10,000 Americans have been prescribed PCSK9is because the kind of familial...
$ESPR long. Hey Doc - in today's WSJ, "When Cholesterol Drugs Cost $14,000, an Insurance Tug-of-War" Sumathi Reddy write...
$epigenetics $genetics - interesting new findings Environmental factors dominate over host genetics in shaping hum...
Would it not be true that most of the medications prescribed to patients is do to the growth of baby boomers getting old...
Many people are allergic to niacin, including myself. Incredibly itchy midriff. I used it for my cholesterol...
Dear Doc G -- Thank you for the thoughtful response. I did not mean to imply that you have never differentiated between...
Stock Gumshoe has demonstrated that he has the analytical and investigative skills to uncover marketing scams by individ...
Sadly, the 'doc' is woefully behind in such matters. 'Under our belt?' Hardly, such drugs, while lowering cholesterol, h...
Hey, Thanks so much for this post! I am glad to see that you are taking the time to respond to different comments. Your...
$ESPR (long). Is it such a short time, reds 47? This paragraph is from their website. Top-line results from the globa...
RE:$ESPR/DR KSS note: since i am new to this community, i had not read your earlier analysis of the cholesterol alternat...
A report, if I may, on the cholesterol wars. As you know by now, Amgen's CVOT, a mere two-year one, for PCK9i Repatha...
$ESPR $AMGN Amgen discounts cholesterol drug, but payers want more http://www.reuters.com/article/us-heart-amgen-pri...
$ESPR http://www.investors.com/news/technology/esperion-dive-on-amgen-heart-study-counter-intuitive-on-pricing/ Esper...
AD to Dietary Cholesterol Study rigorous? The Study may be rigorous but it is flawed in design. Blood cholesterol and im...
There are other studies which point to an association of AD/dementia and the use of statin drugs. (See the works of Dr....
Interesting Raka I put Coconut Oil and Whey powder and Flax Seed Oil in my smoothies to fix my cholesterol. There are st...
Long the dash, Doc KSS and the Gummune. And thanks for an answer that has redefined my relation to my high cholesterol. ...
I nominate that for post of the year! Re genes, a dear friend had very high cholesterol levels from the time when ...
$ESPR long long and increasing position - Thank you Doc for an amazing answer. Your knowledge is deep and you are such a...
$ESPR long 1/2 position Esperion is up 57% since I established the position early February and the only catalyst I can ...
OT: Hello all, I haven't posted or read in some time, but could someone direct me to our discussion on statins? I'm a bi...
Oh, the initials are enough to puzzle anybody. LDL-C is just LDL cholesterol. I tend to stick the C on because LDL b...
I posted about this above. A huge cardiovascular outcomes trial of Amgen's PCSK-9 inhibitor Repatha has concluded, and...
Thanks Alanh! RE: $ESPR Go figure. I kept delaying getting back in given the time frame of the trials, but many may be r...
Quite the contrary. There is a significant amount of evidence that oxidation of ApoB-100 which is the protein that enca...
$ESPR, $AMGN As you've doubtless seen, a huge (27000 patient) cardiovascular outcomes trial of $AMGN's PCSK-9 inhibit...
Quote from Michael. Fossel's Book Telomerase Revolution: circulating monocytes and platelets begin to adhere to the e...
The first news was that statins achieve their effect by blocking cholesterol buildup. They do indeed block endogenous ch...
Opposable: Catabasis is a smart cadre of people and looks quite oversold here though I predict it will reflate only grad...
$CATB Catabasis Pharmaceuticals Halted, Duchenne Muscular Dystrophy Treatment Study Results Not Statistically Significa...
$ESPR $MRK $AMGN #CETP - An interesting and timely article on Merck's anacetrapib and a mini review of the CETP field. ...
What a wonderful world we live in. You and many others give us information to improve our health. All we have to do i...
Lowering cholesterol does not eliminate plaque buildup, nor deaths due to vascular blockage.Very few diabetic people eve...
Q10 does not lower colesterol, the importance of supplementing with Q10, is when you are using statins to lower choleste...