Topic Archives: cholesterol

Doc Gumshoe is not in the habit of contradicting the conclusions, backed by research, that are stated in papers published by the Journal of the American Medical Association, commonly referred to as JAMA.    JAMA is, after all, one of a handful of the most prestigious medical journals on the planet, along with the New […]

[ed note: Michael Jorrin is longtime medical writer who has been sharing his thoughts with our readers as “Doc Gumshoe” for several years (he’s not a doctor, I gave him the name). He generally covers medical and health news and sometimes health promotions and hype, but he rarely opines about investments or specific stocks. All […]

[Ed. Note: Dr. KSS writes about medical topics and biotech stocks for the Irregulars. He has agreed to our trading restrictions, and his thoughts and words are his own. Enjoy!] Any discussion of cholesterol immediately turns Brobdingnagian, such are the extremes in question. Statins, which lower LDL cholesterol, are bombastically the best-selling drugs of all […]

Comments

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    One thing is for sure and that is Cholesterol drugs for many are the biggest rip off and Hype in the past 30 years. Firs...

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    Cholesterol is not a causative agent of heart disease. It is involved in plaque production after vascular wall inflammat...

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    Yet several more nails in the coffin of the "cholesterol hypothesis" of cardiovascular disease. LDL cholesterol plays ab...

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    Hope you can get it. My doctors are adhering to restrictions put on that delay use until too late. I asked them straigh...

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    It is easy to do a search which reveals that among "senior citizens"; the higher the overall cholesterol level is = a hi...

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    Unfortunate for you if you don't start buying in phases here.....this is a $100 stock in the next 24 mos....

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    Doctors who prescribe statins will tell you it is to "balance" your high and low cholesterol. It need not be high chole...

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    Hi Travis - any thoughts of AMRN? Another potential therapy for high cholesterol (LDL I would presume)....

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    Any Thoughts on AMRN? Another potentially Cholesterol lowering supplement or drug....

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    I feel compelled to add to Dr. KSS's post. I am a retired physician who was treated on and off with statins for high cho...

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    Thanks to Doc Gumshoe for another valuable, informative post. One point that bears repeating is the effects of statins ...

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    Well, if you're sticking to the biased data that predominates medical research, then the benefit of statins is only marg...

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    CRP has to be specifically tested. It's a separate risk marker. Keep in mind all of these measurements are markers, no...

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    Vitamin C is weak at best for preventing oxidization of cholesterol (it is a lipid after all, and C is water soluble). ...

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    Not hard to figure out why. Celery contains nitrates which boost nitric oxide production in the endothelium walls. The...

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    Nowhere does this article mention the effects of sugar and insulin resistance in causing heart disease. That is no sur...

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    Michael Jorrin, Thanks for your answer, but I'm afraid my question was ambiguous. I didn't ask if each of the condition...

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    Thanks for another interesting article, Sr Jorrin, aka Doc Gumshoe. I looked back at my latest test results from 3 wee...

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    I had a 'mild' heart attack which resulted in a stent and 80 mg statin prescription. After a year of headaches, I com...

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    Dr Linus Pauling discovered that inflamation in blood vessels is caused by inadequate levels of vitamin C, which alowed ...

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    My two cents worth. In May 2017 a heart cath showed I had 3 arteries 90-95% blocked (including the LAD), the RCA was 100...

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    Agreed. There have been several books written about this, including "The Cholesterol Myth." Lipitor has been the best se...

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    I have a high cholesterol rate (above 200), but I exercise vigorously and often (tennis), I eat a healthy diet, which i...

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    Another sample of 1. Have had high cholesterol all my life as does my 97-year-old mother and don't take meds. Started t...

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    Doc, Most US Dr.s still recommend statins for patients whose cholesterol exceeds guidelines even if they have had not ...

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    The thing that appears to be overlooked is the differentiation between saturated and polyunsaturated fats. The AHA was ...

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    I don't mean to slight your presentation, but, I read this long essay expecting to get a question at the end--and I don'...

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    Like cancer and heart disease, there won't be an artificial drug cure for Alzheimer's either. For all three, it isn't...

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    AMRN, AdCom for Viscera mid-Nov, PDUFA late Dec, outstanding results, much needed for Big Pharma pipelines, so likely a ...

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    Dr. Paton, Since Ansel Keys 7-country-Study was a fraud report that generated entire Margarine and Statin industry,...

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    not to be flippant but everyone dies eventually and most do not have high cholesterol I would think?...

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    Can you furnish links to: "More people die with low cholesterol than with high."...

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    I'll pass. Cholesterol is not the enemy people believe it to be, and the evidence supporting the use of Statins or any c...

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    More people die with low cholesterol than with high. These drugs are more about making money than concern with peoples' ...

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    Potential adverse effects of NRF2 activation Genetic activation of NRF2 may promote the development of de novo cancerous...

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    Pharmageddon Forty years ago Ancel Keys2 sold the concept of the cholesterol etiology of cardiovascular disease, an...

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    It seems unfortunate that a discussion of eggs and cholesterol in so many instances has degenerated into what I can only...

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    Not only does dietary cholesterol account for only about 15% of total serum cholesterol, but I have read that another co...

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    I'm 88. My blood pressure measures in the range of 120/65 +/- 5; pulse usually around 60 except mornings ~55. Not diabet...

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    Hi Doc Gumshoe, I am an egg lover and statin hater of longstanding. For many years, when young I ate cereal product usu...

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    Eggs are nearly perfect food. The 'culprits' have been widely determined to be sugar (say, high glucose corn syrup), car...

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    I am 80 and get regular blood tests, have all necessary vaccines up to date, take simvastatin and have very good cholest...

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    I have no faith in the use of statins in treating cholesterol and many physicians feel the same way. There has always be...

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    Nice analysis Dr. G, but what about ALSO looking at why the body makes cholesterol in the steroid tree, and its complex ...

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    I think the egg debate is definitely inconclusive at this point. As a pathologist who has cut through calcified atherosc...

  • Jay Ram

    Learning that our bodies synthesize most of the cholesterol we use helped me realize that exercise is the controllable f...

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    The cholesterol story is on a par with man-made-warming. The former generates $50Bn in revenue thus funding volumes of s...

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    Thank you, Doc! My doctors have been bugging me to take statin drugs to lower my cholesterol levels and I cannot tolerat...

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    Excellent article. Heart disease runs in my family. My cholesterol was naturally high till I changed my diet. My fath...

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    Eat eggs every day with scrapple, ham or bacon. Statin keeps my cholesterol, under control. Every time I reduce my 2/d ...

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    The best way to fight alzheimers is a KETO diet ! brains need cholesterol ( cell making substance) KETO feeds brains ke...

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    Another "cover-up" of natural cures? After sitting through most of their video presentation, I opted for their book and ...

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    More evidence that cholesterol (LDL) has no effect on heart: https://www.irishtimes.com/news/health/no-evidence-high-...

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    Just a FYI for folks with a cholesterol problem. Some pharmaceuticals are a dangerous solution to a simple problem. AKA ...

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    I am so tired of being hyped. Although these type of ads have been a great and costly learning experience for me. The...

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    To all those that are saying that high cholesterol is not bad for you and does not cause heart disease you are wrong and...

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    Also research shows that once you are over 70 years old and have no history of heart disease those with higher cholester...

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    Due to inflammation reduction? KSS promoted this aspect, company seems to downplay it. Riding on the cholesterol fear ca...

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    My family typically lives into their 90's (previous 2 generations / both sides). I have high cholesterol, assume they di...

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    The above people who said statin drugs are a fraud perpetrated on the American people by Big Pharma are 100 percent corr...

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    I agree with you 100%. Forty five years ago I was diagnosed with high cholesterol (300 Total) and was put on statins th...

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    It will be a discovery of majestic proportions to discover a drug which is effective for dyslipidaemias - incorrect / el...

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    The better news is that we have been duped for about the last 50 years about what causes heart attacks and heart disease...

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    I was trying to figure this out myself, after doing a little research i think the ticker is ESPR.. @ $43/Share roughly.....

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    Ha, have to try that. Thanks Cleveland. See, that's the trouble with a lot of our society. Simple stuff that work...

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    STM, I claim no expertise. I couldn't use statins. I think $ESPR has an important niche. I don't believe that the man...

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    #ESPR Listened to the call this a.m. I understood deaths not related to ESPR. Many trial study participants are sick pe...

  • SoGiAm

    #ESPR 2 in moderation Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bemp...

  • SoGiAm

    $ESPR > Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bempedoic Acid ht...

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    I'm puzzled about the above comment that I supposedly made. I don't recall it, and certainly don't agree that the essay ...

  • JohnM

    Author: Roger I guess whether statins provide longevity remains an issue. I had muscle deterioration and problems with...

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    Lannas, at this moment, you're right. I didn't sell $ESPR. I guess whether statins provide longevity remains in issue....

  • SoGiAm

    $ESPR sp - (long no link) Esperion Announces Positive Top-Line Results from First Pivotal Phase 3 Study of Bempedoic Aci...

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    Variant Pharam was founded 2014 and is a Private company. Website: https://www.variantpharma.com/ Lead orphan drug...

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    Two very important things to consider are bad fats and sugar. Sugar causes glycation so the proteins don't work properl...

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    $NoTicker Speaking of cholesterol - Here is some fun and eyebrow raising work (N = not very many, yet), in which l...

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    $ESPR question for chartists: what support level are you seeing given the steady run-up until today? Decline today ...

  • SoGiAm

    $ESPR related sp - Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor http://www.cel...

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    $MDGL $ESPR MDGL Achieves Primary Endpoint in Patients with NASH. https://finance.yahoo.com/news/madrigal-mgl-3196-ac...

  • SoGiAm

    $KPTI np 8K Filed with the SEC http://investors.karyopharm.com/secfiling.cfm?filingid=1193125-17-358925&CIK=1503802 ...

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    i don't believe in the drugs prescribed by most doctors. I have read that former heads of the FDA pushed for acceptance ...

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    Thank you, Doc G. I appreciate the way you've identified trends in both causation and reduction, but also identified co...

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    $ESPR Esperion to Participate in Fireside Chat at the Jefferies 2017 London Healthcare Conference GlobeNewswire•No...

  • SoGiAm

    $CRISPR-Cas9 - Nanotech, gene editing used to edit cholesterol gene: U.S. study https://www.reuters.com/article/us-hea...

  • DrKSSMDPhD

    My personal suggestion is using this forum first for questions. People like Rice and Chow work very very hard, and if I ...

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    $AMYT. ralph, I’m not denying that you may be correct, since even the occasional Dr KSS recommendation has fallen by t...

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    I could not agree more with you Maryanne. Back in April, I ruptured my achilles tendon and was laid up at home for 3 mon...

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    $MRK $ESPR $CETP Barron's article: "Merck: Heartbreak over a cholesterol drug" In excerpts: In study data releas...

  • Subramania Kaushik

    I agree on $ESPR. They are also actively looking for a partnership. $MRK might end up abandoning CETP and they dont want...

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    $ESPR (of high relevance) $MRK $CETP Merck hits a bloop single in an epic PhIII CETP cardio contest. Now what? (Endpo...

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    $PCSK9 $ESPR $AMGN New findings reported today at the ESC Congress: "PCSK9 Is A Co-Activator Of Platelet Function ...

  • SoGiAm

    $ESPR long - Prices at $49 - Esperion Prices Public Offering of Common Stock http://investor.esperion.com/releasedetai...

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    $ESPR np sold today at 53.00 Esperion Announces Proposed Public Offering of Common Stock 4:31 pm ET August 8, 2017 (Glo...

  • SoGiAm

    $ESPR - Esperion Announces Proposed Public Offering of Common Stock http://globenewswire.com/news-release/2017/08/08/10...

  • DrKSSMDPhD

    Hi: thanks for posting and asking. As regards Esperion, we still love the company, and it is one of multiple moving targ...

  • DrKSSMDPhD

    Eyedoc is right. I had a tempestuous dream last night that somehow I was being seen by a physician semi-against my wishe...

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    Hi Dr. KSS. I'd like to add my experiences with Metf0rmin. I've been taking metformin since 2007 at the urging of my ph...

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    And one more from biopharma drive: "This could either be due to lower than expected efficacy, adverse events seen in ...

  • DrKSSMDPhD

    Esperion shares may sputter this morning on new from $MRK that anacetrapib met primary study goals in a CVOT. I hope rea...

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