Topic Archives: cholesterol

Solving the Healthy Returns pitch: “Retire 10 TIMES RICHER” — What’s their “#1 Best Biotech to Cure Your Retirement Money Worries?”

We haven’t looked at a biotech teaser pitch in a little while, so this one for a new Mauldin Economics newsletter caught my eye… Chris Wood is helming Healthy Returns, along with celebrity doctor Michael Roizen (now referred to as a “wellness guru” and head of the Wellness Institute at the Cleveland Clinic, he is […]

A Non-Statin Pill That Really Lowers Cholesterol, Blood Pressure and Inflammation without Side Effects Would be a Good Investment, Right?

[Ed. Note: Dr. KSS writes about medical topics and biotech stocks for the Irregulars. He has agreed to our trading restrictions, and his thoughts and words are his own. Enjoy!] Any discussion of cholesterol immediately turns Brobdingnagian, such are the extremes in question. Statins, which lower LDL cholesterol, are bombastically the best-selling drugs of all […]

Comments

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    Pharmageddon Forty years ago Ancel Keys2 sold the concept of the cholesterol etiology of cardiovascular disease, an...

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    It seems unfortunate that a discussion of eggs and cholesterol in so many instances has degenerated into what I can only...

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    Not only does dietary cholesterol account for only about 15% of total serum cholesterol, but I have read that another co...

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    I'm 88. My blood pressure measures in the range of 120/65 +/- 5; pulse usually around 60 except mornings ~55. Not diabet...

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    Hi Doc Gumshoe, I am an egg lover and statin hater of longstanding. For many years, when young I ate cereal product usu...

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    Eggs are nearly perfect food. The 'culprits' have been widely determined to be sugar (say, high glucose corn syrup), car...

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    I am 80 and get regular blood tests, have all necessary vaccines up to date, take simvastatin and have very good cholest...

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    I have no faith in the use of statins in treating cholesterol and many physicians feel the same way. There has always be...

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    Nice analysis Dr. G, but what about ALSO looking at why the body makes cholesterol in the steroid tree, and its complex ...

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    I think the egg debate is definitely inconclusive at this point. As a pathologist who has cut through calcified atherosc...

  • RampageKy

    Learning that our bodies synthesize most of the cholesterol we use helped me realize that exercise is the controllable f...

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    The cholesterol story is on a par with man-made-warming. The former generates $50Bn in revenue thus funding volumes of s...

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    Thank you, Doc! My doctors have been bugging me to take statin drugs to lower my cholesterol levels and I cannot tolerat...

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    Excellent article. Heart disease runs in my family. My cholesterol was naturally high till I changed my diet. My fath...

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    Eat eggs every day with scrapple, ham or bacon. Statin keeps my cholesterol, under control. Every time I reduce my 2/d ...

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    The best way to fight alzheimers is a KETO diet ! brains need cholesterol ( cell making substance) KETO feeds brains ke...

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    Another "cover-up" of natural cures? After sitting through most of their video presentation, I opted for their book and ...

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    More evidence that cholesterol (LDL) has no effect on heart: https://www.irishtimes.com/news/health/no-evidence-high-...

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    Just a FYI for folks with a cholesterol problem. Some pharmaceuticals are a dangerous solution to a simple problem. AKA ...

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    I am so tired of being hyped. Although these type of ads have been a great and costly learning experience for me. The...

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    To all those that are saying that high cholesterol is not bad for you and does not cause heart disease you are wrong and...

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    Also research shows that once you are over 70 years old and have no history of heart disease those with higher cholester...

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    Due to inflammation reduction? KSS promoted this aspect, company seems to downplay it. Riding on the cholesterol fear ca...

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    My family typically lives into their 90's (previous 2 generations / both sides). I have high cholesterol, assume they di...

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    The above people who said statin drugs are a fraud perpetrated on the American people by Big Pharma are 100 percent corr...

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    I agree with you 100%. Forty five years ago I was diagnosed with high cholesterol (300 Total) and was put on statins th...

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    It will be a discovery of majestic proportions to discover a drug which is effective for dyslipidaemias - incorrect / el...

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    The better news is that we have been duped for about the last 50 years about what causes heart attacks and heart disease...

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    I was trying to figure this out myself, after doing a little research i think the ticker is ESPR.. @ $43/Share roughly.....

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    Ha, have to try that. Thanks Cleveland. See, that's the trouble with a lot of our society. Simple stuff that work...

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    STM, I claim no expertise. I couldn't use statins. I think $ESPR has an important niche. I don't believe that the man...

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    #ESPR Listened to the call this a.m. I understood deaths not related to ESPR. Many trial study participants are sick pe...

  • Gr8Full!

    #ESPR 2 in moderation Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bemp...

  • Gr8Full!

    $ESPR > Esperion Announces Positive Top-Line Results from Pivotal Phase 3 Long-Term Safety Study of Bempedoic Acid ht...

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    I'm puzzled about the above comment that I supposedly made. I don't recall it, and certainly don't agree that the essay ...

  • JohnM

    Author: Roger I guess whether statins provide longevity remains an issue. I had muscle deterioration and problems with...

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    Lannas, at this moment, you're right. I didn't sell $ESPR. I guess whether statins provide longevity remains in issue....

  • Gr8Full!

    $ESPR sp - (long no link) Esperion Announces Positive Top-Line Results from First Pivotal Phase 3 Study of Bempedoic Aci...

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    Variant Pharam was founded 2014 and is a Private company. Website: https://www.variantpharma.com/ Lead orphan drug...

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    Two very important things to consider are bad fats and sugar. Sugar causes glycation so the proteins don't work properl...

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    $NoTicker Speaking of cholesterol - Here is some fun and eyebrow raising work (N = not very many, yet), in which l...

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    $ESPR question for chartists: what support level are you seeing given the steady run-up until today? Decline today ...

  • SoGiAm

    $ESPR related sp - Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor http://www.cel...

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    $MDGL $ESPR MDGL Achieves Primary Endpoint in Patients with NASH. https://finance.yahoo.com/news/madrigal-mgl-3196-ac...

  • SoGiAm

    $KPTI np 8K Filed with the SEC http://investors.karyopharm.com/secfiling.cfm?filingid=1193125-17-358925&CIK=1503802 ...

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    i don't believe in the drugs prescribed by most doctors. I have read that former heads of the FDA pushed for acceptance ...

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    Thank you, Doc G. I appreciate the way you've identified trends in both causation and reduction, but also identified co...

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    $ESPR Esperion to Participate in Fireside Chat at the Jefferies 2017 London Healthcare Conference GlobeNewswire•No...

  • SoGiAm

    $CRISPR-Cas9 - Nanotech, gene editing used to edit cholesterol gene: U.S. study https://www.reuters.com/article/us-hea...

  • Dr. KSS MD PhD

    My personal suggestion is using this forum first for questions. People like Rice and Chow work very very hard, and if I ...

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    $AMYT. ralph, I’m not denying that you may be correct, since even the occasional Dr KSS recommendation has fallen by t...

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    I could not agree more with you Maryanne. Back in April, I ruptured my achilles tendon and was laid up at home for 3 mon...

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    $MRK $ESPR $CETP Barron's article: "Merck: Heartbreak over a cholesterol drug" In excerpts: In study data releas...

  • Subramania Kaushik

    I agree on $ESPR. They are also actively looking for a partnership. $MRK might end up abandoning CETP and they dont want...

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    $ESPR (of high relevance) $MRK $CETP Merck hits a bloop single in an epic PhIII CETP cardio contest. Now what? (Endpo...

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    $PCSK9 $ESPR $AMGN New findings reported today at the ESC Congress: "PCSK9 Is A Co-Activator Of Platelet Function ...

  • SoGiAm

    $ESPR long - Prices at $49 - Esperion Prices Public Offering of Common Stock http://investor.esperion.com/releasedetai...

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    $ESPR np sold today at 53.00 Esperion Announces Proposed Public Offering of Common Stock 4:31 pm ET August 8, 2017 (Glo...

  • SoGiAm

    $ESPR - Esperion Announces Proposed Public Offering of Common Stock http://globenewswire.com/news-release/2017/08/08/10...

  • Dr. KSS MD PhD

    Hi: thanks for posting and asking. As regards Esperion, we still love the company, and it is one of multiple moving targ...

  • Dr. KSS MD PhD

    Eyedoc is right. I had a tempestuous dream last night that somehow I was being seen by a physician semi-against my wishe...

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    Hi Dr. KSS. I'd like to add my experiences with Metf0rmin. I've been taking metformin since 2007 at the urging of my ph...

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    And one more from biopharma drive: "This could either be due to lower than expected efficacy, adverse events seen in ...

  • Dr. KSS MD PhD

    Esperion shares may sputter this morning on new from $MRK that anacetrapib met primary study goals in a CVOT. I hope rea...

  • Dr. KSS MD PhD

    Glenn, tempest in a teapot really. Fewer than 10,000 Americans have been prescribed PCSK9is because the kind of familial...

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    $ESPR long. Hey Doc - in today's WSJ, "When Cholesterol Drugs Cost $14,000, an Insurance Tug-of-War" Sumathi Reddy write...

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    $epigenetics $genetics - interesting new findings Environmental factors dominate over host genetics in shaping hum...

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    Would it not be true that most of the medications prescribed to patients is do to the growth of baby boomers getting old...

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    Many people are allergic to niacin, including myself. Incredibly itchy midriff. I used it for my cholesterol...

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    Dear Doc G -- Thank you for the thoughtful response. I did not mean to imply that you have never differentiated between...

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    Stock Gumshoe has demonstrated that he has the analytical and investigative skills to uncover marketing scams by individ...

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    Sadly, the 'doc' is woefully behind in such matters. 'Under our belt?' Hardly, such drugs, while lowering cholesterol, h...

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    Hey, Thanks so much for this post! I am glad to see that you are taking the time to respond to different comments. Your...

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    $ESPR (long). Is it such a short time, reds 47? This paragraph is from their website. Top-line results from the globa...

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    RE:$ESPR/DR KSS note: since i am new to this community, i had not read your earlier analysis of the cholesterol alternat...

  • Dr. KSS MD PhD

    A report, if I may, on the cholesterol wars. As you know by now, Amgen's CVOT, a mere two-year one, for PCK9i Repatha...

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    $ESPR $AMGN Amgen discounts cholesterol drug, but payers want more http://www.reuters.com/article/us-heart-amgen-pri...

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    $ESPR http://www.investors.com/news/technology/esperion-dive-on-amgen-heart-study-counter-intuitive-on-pricing/ Esper...

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    AD to Dietary Cholesterol Study rigorous? The Study may be rigorous but it is flawed in design. Blood cholesterol and im...

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    There are other studies which point to an association of AD/dementia and the use of statin drugs. (See the works of Dr....

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    Interesting Raka I put Coconut Oil and Whey powder and Flax Seed Oil in my smoothies to fix my cholesterol. There are st...

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    Long the dash, Doc KSS and the Gummune. And thanks for an answer that has redefined my relation to my high cholesterol. ...

  • arch1

    I nominate that for post of the year! Re genes, a dear friend had very high cholesterol levels from the time when ...

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    $ESPR long long and increasing position - Thank you Doc for an amazing answer. Your knowledge is deep and you are such a...

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    $ESPR long 1/2 position Esperion is up 57% since I established the position early February and the only catalyst I can ...

  • Gui

    OT: Hello all, I haven't posted or read in some time, but could someone direct me to our discussion on statins? I'm a bi...

  • Michael Jorrin (aka Doc Gumshoe)

    Oh, the initials are enough to puzzle anybody. LDL-C is just LDL cholesterol. I tend to stick the C on because LDL b...

  • Anamorph

    I posted about this above. A huge cardiovascular outcomes trial of Amgen's PCSK-9 inhibitor Repatha has concluded, and...

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    Thanks Alanh! RE: $ESPR Go figure. I kept delaying getting back in given the time frame of the trials, but many may be r...

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    Quite the contrary. There is a significant amount of evidence that oxidation of ApoB-100 which is the protein that enca...

  • Anamorph

    $ESPR, $AMGN As you've doubtless seen, a huge (27000 patient) cardiovascular outcomes trial of $AMGN's PCSK-9 inhibit...

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    Quote from Michael. Fossel's Book Telomerase Revolution: circulating monocytes and platelets begin to adhere to the e...

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    The first news was that statins achieve their effect by blocking cholesterol buildup. They do indeed block endogenous ch...

  • Dr. KSS MD PhD

    Opposable: Catabasis is a smart cadre of people and looks quite oversold here though I predict it will reflate only grad...

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    $CATB Catabasis Pharmaceuticals Halted, Duchenne Muscular Dystrophy Treatment Study Results Not Statistically Significa...

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    $ESPR $MRK $AMGN #CETP - An interesting and timely article on Merck's anacetrapib and a mini review of the CETP field. ...

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    What a wonderful world we live in. You and many others give us information to improve our health. All we have to do i...

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    Lowering cholesterol does not eliminate plaque buildup, nor deaths due to vascular blockage.Very few diabetic people eve...

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    Q10 does not lower colesterol, the importance of supplementing with Q10, is when you are using statins to lower choleste...

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