Topic Archives: coagulation

In his tearjerker “Sisters of Mercy,” Leonard Cohen sings, I’ve been where you’re hanging and think I can see how you’re pinned. Although I am less inclined to bash the FDA than many, it has recently let modern medical practice place many patients in an undesirable situation. What if there was a very powerful drug, […]

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  • DrKSSMDPhD

    Rutledge Ellis Behnke invented AC5 by emulating nature. In coagulation and in hemostasis, RGD is a protein structural mo...

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    $ARTH Sorry nonsense. You went to IHUB and scared everyone there. You probably went several other places on the in...

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    K2 is not entirely free of bad side effects. K2 is involved in the blood coagulation process in that an individual treat...

  • DrKSSMDPhD

    Eyedoc, yes I think it's doomed. Factor D is a serine proteinase that participates only to generate factor B via the alt...

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    $ARTH Someone with a PHD in Molecular Biology of Coagulation Regulation would know something about $ARTH. Thank you D...

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    Conference https://fccdl.in/yoDfHt7g9 3:09.27 Dr. KSS PHD in Molecular Biology of Coagulation Regulation...

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    #Conference Call In the Conference Call Doc mentioned his focus in his PHD program. Did anyone catch what Doc's PHD i...

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    DR. KSS, I see some coagulation gauze products at drug stores that say they are for external use, but also suggest they ...

  • DrKSSMDPhD

    One comment about the new Zafgen data is this, and it's curiosity-rousing though not long-thesis-puncturing: "As prev...

  • AC/DC

    $ZFGN Well this is all one needs to read in todays press release? Thank you Doc. "There was no prothrombotic effec...

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    $ZFGN long - BOSTON, May 04, 2017 (GLOBE NEWSWIRE) -- Zafgen, Inc. (Nasdaq:ZFGN) today announced positive topline data f...

  • DrKSSMDPhD

    Diplacus....be of good cheer. No disrespect taken and no admonition intended. Look, let's walk you through this. Under a...

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    $ZFGN np and still pissed at mgmt but found this interesting in the earnings call: "over the past year we've learned ...

  • DrKSSMDPhD

    Bad genes? You? I doubt it! But genes adapt us for life in different settings. If you were with a group of people on the...

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    If I remember correctly, one area of DR KSS's PhD expertise is coagulation. Is there anything in the chemical make up ...

  • DrKSSMDPhD

    Someone, jokin I think, was asking yesterday about a clipping from Sciencedaily and its relevance to $ZFGN. The clipping...

  • DrKSSMDPhD

    Hi: Yes I'd be happy to help you. Coagulation is my favorite area of medicine. Just forward me a message via lynn@stockg...

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    Ok Newbie ----Arch Therapeutics (Symbol ARTH) Dr. KSS:Comments “I can tell you from my perspective as someo...

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    18% (12 patients) had a thrombotic event within 30 days 10 of which actually died. Only one of those patients had their ...

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    $ARTH, Here's my layman's take. This was a skin lesion trial. It doesn't seem like it would take much to get coagulati...

  • DrKSSMDPhD

    Hi sfimar and welcome to the Gummune. You pose a wise and good question, and as you'll see, you and I are of like mind. ...

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    $TTOO: It is worth mentioning that T2 recently signed a multi-year agreement to provide T2 Magnetic Resonance technology...

  • DBMD

    $PTLA tag on to Dr. KSS note. In brain bleeds, CNS and retroperitoneal bleeds on Xa inhbs like Xarelto the outcome of AA...

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    TTOO extends partnership with big time player Bayer today with blood coagulation disorders. This company in my opinion ...

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    http://www.dropbox.com user name: stock.gumshoe@outlook.com pswd: ForAllGummies https://www.dropbox.com/home/ARTH?p...

  • DrKSSMDPhD

    Hi....perfectly good question. Aspirin "thins" the blood on the basis of confounding one pathway for platelet aggregatio...

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    Ditto: ''It’s looking more and more as if beloranib really tweaks coagulation unfavorably''. Is this something we shou...

  • DrKSSMDPhD

    New data from Zafgen's Australian diabesity phase 2b trial. There were 3 clots: 1 previously reported, and 2 detected...

  • drbonz

    Interesting. From these, it looks like the control is not another agent but instead is Tegaderm, which is a sticky "Sar...

  • DrKSSMDPhD

    Good morning to all. I'm in the Finger Lakes region of New York visiting relatives and being reminded of the spectacular...

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    Dr.KSS: Wonderfully crafted article. The teaching points on coagulation were great and helped me with my questions on an...

  • DrKSSMDPhD

    From 16 Mar 16: http://www.prnewswire.com/news-releases/novuson-surgical-awarded-15-m-grant-by-nih-to-advance-direct-the...

  • DrKSSMDPhD

    Thank you Cleveland. That's quite nice of you. If he approached me, I would gladly help him. I believe in the product an...

  • SoGiAm

    ARWR- Arrowhead Presents Promising New Preclinical Data on ARC-F12 at AAAAI 2016 PASADENA, Calif.--(BUSINESS WIRE)-- A...

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    It's better that these agents AC5 and TDM-621 DO NOT act as anti-coagulants. Non-coagulating hemostasis is the point...

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    I did not see one mention of TDM-621 acting pursuant to patient on a anticoagulant. That is strange. That is a big item...

  • DrKSSMDPhD

    in coagulation medicine, absence of evidence is not evidence of absence. For patients with clear clinical histories of c...

  • DrKSSMDPhD

    DBMD: Yes, I think every pt is now being assessed for functional antithrombin-III, functional plasminogen, fV Leiden, pr...

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    it’s good to hear the opinion that Puramatrix is different from AC5. The following is what had me thinking (and I ad...

  • DrKSSMDPhD

    I am because I see nothing that affects the long term story. It's a great drug. I wish they'd replace the CEO, but I ...

  • SoGiAm

    ARWR-8K: http://ir.arrowheadresearch.com/secfiling.cfm?filingid=1564590-15-6061&CIK=879407 includes updates on ARC-520, ...

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    The point was not to bring up RGDO. In fact I think some might have forgotten the science that was presented regarding h...

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    $ARTH Most posts that question $ARTH competitors overlook the ginormous fact that AC5 is a medical device. It is much e...

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    Found an interesting article about coagulation and anti-coagulation. Seems coagulation can be deadly! Perhaps one could...

  • drbonz

    Dr. If you reread my post, I certainly did not "bad mouth" $ARTH. I have bought quite a bit of it in fact. I simply p...

  • DrKSSMDPhD

    Not true. AC5 is hemostatic, not coagulative. The others are coagulative and incur serious problems. Use of a chitos...

  • DrKSSMDPhD

    Yes, correct. You could have an INR of 15 and zero platelets, and AC5 will still stop your bleeding immediately. It neit...

  • DrKSSMDPhD

    Today the FDA has approved an agent that competes with Arch's AC5, called Raplixa. http://www.fda.gov/NewsEvents/Newsro...

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    The results are positive for the predominantly classic type of wet CNV membrane. This type of CNV membrane, which requir...

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    Portola Announces Full Results From Positive Phase 3 ANNEXA(TM)-R Study Demonstrating That Andexanet Alfa Rapidly and Si...

  • AC/DC

    Doc, since you love companies dealing with blood coagulation, here is Opko Health ($OPK) that filed an IND for study of ...

  • DrKSSMDPhD

    CNBC has run him before....not sure why again. In fact there are at least 5 other products out there that do the same th...

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    There has been a great deal of discussion on this thread in the past 10 days regarding the risks and benefits of using p...

  • DrKSSMDPhD

    Those ASC's are GI's dirty little secret, in my view. We now see clearly, for example, why Joan Rivers died. People who ...

  • DrKSSMDPhD

    I was communicating with someone here yesterday evening about his situation with type 1 DM, TIA's and being on Plavix (...

  • DrKSSMDPhD

    To ScorpioRising and Kris Prasad: sorry for being a latecomer to the discussion about AAV-8. I appreciate the references...

  • DrKSSMDPhD

    To Frank Archambeau: cool paper on mathematical modeling of metastasis. Using maths to model biological systems is the h...

  • DrKSSMDPhD

    Frank, my PhD was done under a British guy who'd done his DPhil at Cambridge, and was in a lab that mainly studied the r...

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    Perosphere and Daiichi Sankyo ink third collaboration agreement on anticoagulant reversal drug • 1:55 PM Douglas W...

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    In retrospect I think of the complexity of blood coagulation that the Doc laid out. Also, that Coumadin has troubles but...

  • arch1

    Dr KSS Do you have an opinion on$PTLA that just passed a phase 3a going on to ph3b end of 2015? Reverses action of Eliq...

  • DrKSSMDPhD

    Just chatting with Michael Fitzhugh of Bioworld Today. Great guy! His report will run tomorrow: By Michael Fitzhugh, ...

  • DrKSSMDPhD

    Hi Larry: thanks for writing. Sorry he has this. A little more than half of cases are caused by an acquired mutation ...

  • jer_vic

    Last week, visiting my GP, I explained Regado's idea to him. He said the first thing the drug reps get asked when they s...

  • DrKSSMDPhD

    dgcannon: I can assure you that I did not "flame" you. There is only one thing I'd do that for, and that's someone tryin...

  • DrKSSMDPhD

    To Thomas Tucker: regarding Sanuwave, I retain a scientific optimism about it. As I recall, this company recently had so...

  • DrKSSMDPhD

    To BConway: wow, thanks for your very thoughtful and beautifully written post. We are kindred spirits or blood brothers:...

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    Thank you for the fabulous article and new stock recommendation Dr. Karma. I particularly enjoyed the way cool "simplif...

  • karmaswimswami

    To Tim Graber: Thanks for posting about Peregrine Pharma. It is a play on anti-phosphatidylserine antibodies. I wish ...

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