Payola from Portola?In his tearjerker “Sisters of Mercy,” Leonard Cohen sings, I’ve been where you’re hanging and think I can see how you’re pinned. Although I am less inclined to bash the FDA than many, it has recently let modern medical practice place many patients in an undesirable situation. What if there was a very powerful drug, […]
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[ed note: Longtime commenter and reader Dr. KSS, a medical doctor and biotech investor, has agreed to share his thoughts with the Irregulars as one of our guest authors, educating us on health and medicine and sharing some of his biotech investing ideas. He has agreed to the same basic trading restrictions as other paid […]
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Rutledge Ellis Behnke invented AC5 by emulating nature. In coagulation and in hemostasis, RGD is a protein structural mo...
$ARTH Sorry nonsense. You went to IHUB and scared everyone there. You probably went several other places on the in...
K2 is not entirely free of bad side effects. K2 is involved in the blood coagulation process in that an individual treat...
Eyedoc, yes I think it's doomed. Factor D is a serine proteinase that participates only to generate factor B via the alt...
$ARTH Someone with a PHD in Molecular Biology of Coagulation Regulation would know something about $ARTH. Thank you D...
Conference https://fccdl.in/yoDfHt7g9 3:09.27 Dr. KSS PHD in Molecular Biology of Coagulation Regulation...
#Conference Call In the Conference Call Doc mentioned his focus in his PHD program. Did anyone catch what Doc's PHD i...
DR. KSS, I see some coagulation gauze products at drug stores that say they are for external use, but also suggest they ...
One comment about the new Zafgen data is this, and it's curiosity-rousing though not long-thesis-puncturing: "As prev...
$ZFGN Well this is all one needs to read in todays press release? Thank you Doc. "There was no prothrombotic effec...
$ZFGN long - BOSTON, May 04, 2017 (GLOBE NEWSWIRE) -- Zafgen, Inc. (Nasdaq:ZFGN) today announced positive topline data f...
Diplacus....be of good cheer. No disrespect taken and no admonition intended. Look, let's walk you through this. Under a...
$ZFGN np and still pissed at mgmt but found this interesting in the earnings call: "over the past year we've learned ...
Bad genes? You? I doubt it! But genes adapt us for life in different settings. If you were with a group of people on the...
If I remember correctly, one area of DR KSS's PhD expertise is coagulation. Is there anything in the chemical make up ...
Someone, jokin I think, was asking yesterday about a clipping from Sciencedaily and its relevance to $ZFGN. The clipping...
Hi: Yes I'd be happy to help you. Coagulation is my favorite area of medicine. Just forward me a message via lynn@stockg...
Ok Newbie ----Arch Therapeutics (Symbol ARTH) Dr. KSS:Comments “I can tell you from my perspective as someo...
18% (12 patients) had a thrombotic event within 30 days 10 of which actually died. Only one of those patients had their ...
$ARTH, Here's my layman's take. This was a skin lesion trial. It doesn't seem like it would take much to get coagulati...
Hi sfimar and welcome to the Gummune. You pose a wise and good question, and as you'll see, you and I are of like mind. ...
$TTOO: It is worth mentioning that T2 recently signed a multi-year agreement to provide T2 Magnetic Resonance technology...
$PTLA tag on to Dr. KSS note. In brain bleeds, CNS and retroperitoneal bleeds on Xa inhbs like Xarelto the outcome of AA...
TTOO extends partnership with big time player Bayer today with blood coagulation disorders. This company in my opinion ...
http://www.dropbox.com user name: stock.gumshoe@outlook.com pswd: ForAllGummies https://www.dropbox.com/home/ARTH?p...
Hi....perfectly good question. Aspirin "thins" the blood on the basis of confounding one pathway for platelet aggregatio...
Ditto: ''It’s looking more and more as if beloranib really tweaks coagulation unfavorably''. Is this something we shou...
New data from Zafgen's Australian diabesity phase 2b trial. There were 3 clots: 1 previously reported, and 2 detected...
Interesting. From these, it looks like the control is not another agent but instead is Tegaderm, which is a sticky "Sar...
Good morning to all. I'm in the Finger Lakes region of New York visiting relatives and being reminded of the spectacular...
Dr.KSS: Wonderfully crafted article. The teaching points on coagulation were great and helped me with my questions on an...
From 16 Mar 16: http://www.prnewswire.com/news-releases/novuson-surgical-awarded-15-m-grant-by-nih-to-advance-direct-the...
Thank you Cleveland. That's quite nice of you. If he approached me, I would gladly help him. I believe in the product an...
ARWR- Arrowhead Presents Promising New Preclinical Data on ARC-F12 at AAAAI 2016 PASADENA, Calif.--(BUSINESS WIRE)-- A...
It's better that these agents AC5 and TDM-621 DO NOT act as anti-coagulants. Non-coagulating hemostasis is the point...
I did not see one mention of TDM-621 acting pursuant to patient on a anticoagulant. That is strange. That is a big item...
in coagulation medicine, absence of evidence is not evidence of absence. For patients with clear clinical histories of c...
DBMD: Yes, I think every pt is now being assessed for functional antithrombin-III, functional plasminogen, fV Leiden, pr...
it’s good to hear the opinion that Puramatrix is different from AC5. The following is what had me thinking (and I ad...
I am because I see nothing that affects the long term story. It's a great drug. I wish they'd replace the CEO, but I ...
ARWR-8K: http://ir.arrowheadresearch.com/secfiling.cfm?filingid=1564590-15-6061&CIK=879407 includes updates on ARC-520, ...
The point was not to bring up RGDO. In fact I think some might have forgotten the science that was presented regarding h...
$ARTH Most posts that question $ARTH competitors overlook the ginormous fact that AC5 is a medical device. It is much e...
Found an interesting article about coagulation and anti-coagulation. Seems coagulation can be deadly! Perhaps one could...
Dr. If you reread my post, I certainly did not "bad mouth" $ARTH. I have bought quite a bit of it in fact. I simply p...
Not true. AC5 is hemostatic, not coagulative. The others are coagulative and incur serious problems. Use of a chitos...
Yes, correct. You could have an INR of 15 and zero platelets, and AC5 will still stop your bleeding immediately. It neit...
Today the FDA has approved an agent that competes with Arch's AC5, called Raplixa. http://www.fda.gov/NewsEvents/Newsro...
The results are positive for the predominantly classic type of wet CNV membrane. This type of CNV membrane, which requir...
Portola Announces Full Results From Positive Phase 3 ANNEXA(TM)-R Study Demonstrating That Andexanet Alfa Rapidly and Si...
Doc, since you love companies dealing with blood coagulation, here is Opko Health ($OPK) that filed an IND for study of ...
CNBC has run him before....not sure why again. In fact there are at least 5 other products out there that do the same th...
There has been a great deal of discussion on this thread in the past 10 days regarding the risks and benefits of using p...
Those ASC's are GI's dirty little secret, in my view. We now see clearly, for example, why Joan Rivers died. People who ...
I was communicating with someone here yesterday evening about his situation with type 1 DM, TIA's and being on Plavix (...
To ScorpioRising and Kris Prasad: sorry for being a latecomer to the discussion about AAV-8. I appreciate the references...
To Frank Archambeau: cool paper on mathematical modeling of metastasis. Using maths to model biological systems is the h...
Frank, my PhD was done under a British guy who'd done his DPhil at Cambridge, and was in a lab that mainly studied the r...
Perosphere and Daiichi Sankyo ink third collaboration agreement on anticoagulant reversal drug • 1:55 PM Douglas W...
In retrospect I think of the complexity of blood coagulation that the Doc laid out. Also, that Coumadin has troubles but...
Dr KSS Do you have an opinion on$PTLA that just passed a phase 3a going on to ph3b end of 2015? Reverses action of Eliq...
Just chatting with Michael Fitzhugh of Bioworld Today. Great guy! His report will run tomorrow: By Michael Fitzhugh, ...
Hi Larry: thanks for writing. Sorry he has this. A little more than half of cases are caused by an acquired mutation ...
Last week, visiting my GP, I explained Regado's idea to him. He said the first thing the drug reps get asked when they s...
dgcannon: I can assure you that I did not "flame" you. There is only one thing I'd do that for, and that's someone tryin...
To Thomas Tucker: regarding Sanuwave, I retain a scientific optimism about it. As I recall, this company recently had so...
To BConway: wow, thanks for your very thoughtful and beautifully written post. We are kindred spirits or blood brothers:...
Thank you for the fabulous article and new stock recommendation Dr. Karma. I particularly enjoyed the way cool "simplif...
To Tim Graber: Thanks for posting about Peregrine Pharma. It is a play on anti-phosphatidylserine antibodies. I wish ...