Topic Archives: obesity

The Zed Files

[Ed. Note: Dr. KSS writes for the Irregulars about medicine and biotech stocks. He has agreed to our trading restrictions, chooses his own topics, and his words and opinions are his own. Enjoy!] It could be the premise of a tawdry unrated movie that teenage boys sneak glimpses of on Netflix when they’re home alone. […]

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    The trouble is that curtailing smoking for valid health reasons has in part resulted in an epidemic of obesity - all th...

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    Obesity, type 2 diabetes and cancer are all metabolic diseases which can be prevented/reversed by a well formulated keto...

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    Indeed Sears does some weird stuff one would want to pass up but in general at least he gets his patients healthy. Meanw...

  • Gr8Full!

    Restaurant menu labeling is coming. Studies show it reduces average number of calories ordered by 30-50 calories. http:/...

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    I am a firm believer in the value of the Primary Care Physician to the overall health care "system" (ironic laugh here)....

  • Gr8Full!

    Primate fetal hepatic responses to maternal obesity: epigenetic signalling pathways and lipid accumulation http://onlin...

  • Gr8Full!

    The power of #music on the #brain. https://pbs.twimg.com/media/DXt6LTaXkAAAQ71.jpg ty https://twitter.com/LEAD_Coali...

  • Gr8Full!

    $ZFGN fp - March 6, 2018 4:05 PM EST Zafgen Reports Fourth Quarter and Full Year 2017 Financial Results; Announces Posi...

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    Current 2018 US Death Toll: Abortion - 137,080 Tobacco -43,934 Obesity - 38.537 Medical Error - 31,565 Alcohol - 12...

  • Dr. KSS MD PhD

    First peptide to enter clinic mid 1028. Activity read-out early 2019 with regard to NASH and to obesity. After 50 we ...

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    $Lump/Helen/Eyedoc Kudos, I couldn't have said it better myself. Gary, very succinct and poignant. I agree with you 100...

  • Dr. KSS MD PhD

    Not categorically. But in the right context (obesity, insulin resistance, metabolic syndrome) yes, naturally it is quite...

  • JohnM

    $ARTH - Internal trial should start in Ireland in the June quarter. KSS is 100% sure that they have a large contract man...

  • Dr. KSS MD PhD

    A current perspective on $ZFGN is that analysts mostly have left it for dead and that bona fide insider ownership (using...

  • achandra13

    $ZFGN: Just wanted to bring to peoples attention that ZFGN has been quietly rising and has gone up by 30% in the last mo...

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    Alcoholic liver disease will shortly overtake ischaemic heart disease with regard to years of working life lost. The ris...

  • arch1

    Doc Thank you for knowledgeable insight. I have long seen that childhood obesity becomes a life long problem....

  • Dr. KSS MD PhD

    Yes, it's a prevalent notion.....diminished fecal biome diversity, as can be driven by antibiotics, is strongly linked t...

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    $ZFGN Wow...good question. Are they too late? You would really need to drill down on Hatfield. A deep dive to gain co...

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    $CWBR $ZFGN I have also loaded up on CWBR but also continue to hold ZFGN. I reviewed this article from just a month...

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    $CWBR Long & OW ... Obesity market potential article: https://www.bloomberg.com/news/articles/2017-07-04/why-big-pha...

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    $CWBR (long) I was confused by this tweet: "$CWBR will target #AD #AMD #NASH, ASHD, Diabetes, Obesity, & Stati...

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    $CWBR Follow this person on Twitter for all the CWBR research--amazing $CWBR's Genetic Rx for Obesity - to be previe...

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    $CWBR COHBAR INC (OTCMKTS:CWBR) Pushing The Limits Of Life Through Mitochondria Research 10/14/17 Mitochondria ...

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    $CWBR Obesity Nash Go look at Page 16 Reduces Liver Fat Look at slide 3 CohBar CB4209--Doc almost fell out of his ...

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    $CWBR An interesting new research report that lends further support for the rationale of CohBar’s lead assets, CB42...

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    So Les you are getting thumbs down. Pathetic !! We need a new KSS world. Les Exactly right on !! That is exactly ...

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    $metformin Hi Roger, I have been taking metformin now for a few months with minimal issues. It is a very regularl...

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    Malignant Opiophobia is a cultural condition unique to US culture. We insist on seeing harm where none is occurring. ...

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    Re: $ZGNX and fenfluramine. The withdrawal of fenfluramine REALLY irked me. Fen/phen was a magic combination. The only w...

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    hi Doc your concerns about fenfluramine $ZGNX were there "However, fenfluramine was withdrawn from global markets in 1...

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    $RYTM If you click on the pipeline link, you will see they are researching 4 ultra-rare causes of obesity: 1.Pro-opi...

  • SoGiAm

    $RYTM - Peptide-Based Biotech Rhythm Pharmaceuticals sets therms for $100 Million IPO September 25, 2017 Rhythm Pharm...

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    $Fasting on $microbiota Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gu...

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    The whole question of a study using nurses or nuns as a subject appears specious to me. They are not peas in a pod. We...

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    $ZFGN Cancer-induced anorexia inspires potentially powerful antiobesity drug By Ryan CrossAug. 30, 2017 , 1:54 PM ...

  • SoGiAm

    #Obesity - Energy dense foods may increase cancer risk regardless of obesity status - Scienmag #EnergyDense foods ht...

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    Arch, Long $ZFGN. My understanding of ZGN 1061 is it also diverts more calories to energy and tells the body to store le...

  • arch1

    Re $ZFGN, which I am still holding, If I understand correctly the means of weight control being pursued involves jiggeri...

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    As a Zafgan investor I note the Novo N has a couple of entries into the field per today's Endpoint News: Can Novo’s b...

  • SoGiAm

    Engineered Epidermal Progenitor Cells Can Correct Diet-Induced Obesity and Diabetes http://www.cell.com/cell-stem-cell/f...

  • SoGiAm

    Study: Loneliness, Social Isolation Greater Health Problem In US Than Obesity https://www.studyfinds.org/loneliness-so...

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    $ZFGN (relevance) "Thrombin promotes diet-induced obesity through fibrin-driven inflammation" (8/1/2017) Obesity ...

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    $ZFGN (relevance) "Thrombin promotes diet-induced obesity through fibrin-driven inflammation" (8/1/2017) Obesity ...

  • arch1

    Small molecule "hunger hormone" inhibitor; https://scienmag.com/biochemists-link-synthetic-compound-to-hunger-hormone...

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    Thanks Helen for a very interesting read especially with Diabetes and obesity tied in with Dementia. Cheers,Glenn...

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    $Diabetes $Obesity $Alzheimers Disease "Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disea...

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    $ARNA: I think ARENA has two shots that look reasonable.. the PAH (Pulmonary Arterial Hypertension) side first cab off t...

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    Denton: There are other natural treatments for Alzheimer's that do not involve the use of phamacuetical drugs. Dr....

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    $ZFGN Zafgen to Present at the JMP Securities Life Sciences Conference BOSTON, June 13, 2017 (GLOBE NEWSWIRE) -- Z...

  • SoGiAm

    $ZFGN - Zafgen Presents New Data Highlighting Potential of ZGN-1061 for the Treatment of Type 2 Diabetes and Obesity at...

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    $ABIO timeframe only have to wait until fall of this year for P2b readout thats nothing! Present market cap $22 mill...

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    This article comes across as 'Docs' conflicted response to the comments he has received of late calling for clarity in h...

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    $ZFGN Doc How big a threat is Rhythm Pharma to Zafgen? Have seen references that some believe Rhythm will control the ...

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    A Friday question blending 2 different Gummy threads: Which would be a better way to cure America's Obesity problem? T...

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    $No ticker Life expectancy varies from place to place in the US from as much as 86 years to as few as 66. What correl...

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    Todays Med City News notes that obesity drugs are not much prescribed because obesity was not considered an illness and ...

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    $ZFGN long. I have continued to hold my position through thick and thin with this company - though I did strongly consi...

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    Looks like Zafgen (ZFGN) comeback story is still in tact with ZGN-1061 and their edited presentation today. Keys I got ...

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    bioguy I don’t believe in kicking a (bio)guy when he’s already down, so no thumb down from me in this instance – y...

  • arch1

    Olympic rower James Cracknell, running for office says Cuba And N Korea have way to handle obesity. Yeah starve your pe...

  • achandra13

    $ZFGN Just wanted to remind people that Dr. KSS called out this one last month. Though I got burnt badly with ZFGN last ...

  • berthuis

    $ABVX(in Paris) long Abivax is not only interesting because of it's potential functional cure of HIV. It also has a pro...

  • Anamorph

    $ZFGN former very long, currently placeholder position Joe, I am going from memory here but while any effect on testi...

  • Dr. KSS MD PhD

    John: as a physician I am guilty as charged in that I belong to the doctor club. We are horrible in this respect and vie...

  • arch1

    Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat met...

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    Doc, I think that Hughes was setting the stage for the positive reception of top line data with a mending of as many fe...

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    $ZFGN long I listened to Thomas Hughes, PhD presentation at Leerink yesterday. He focused on their new compound ZGN-...

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    $ETRM - EnteroMedics (ETRM) Announces 3-Year Data from vBloc Diabetic Patient Study Published in Journal of Diabetes and...

  • LongOnLife

    Batan, The study you cited from JAMA (presumably authored by Rebecca Vigen ) has been widely debunked. Others have sh...

  • Dr. KSS MD PhD

    A little more about Aytu: I got the sense from the presentation that this company has only VERY recently gotten things i...

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    Nice! Thanks for that, Ben. Now what we need is for the docs to figure out the best bacteria for us to prevent obes...

  • SoGiAm

    Is obesity contagious? @nutrition_facts w/fascinating data/speculations on gut bacteria and pets that spread them http...

  • arch1

    Is this the cause of obesity? https://www.facebook.com/WomenAfter50/photos/a.490297121003785.116537.490293054337525/1...

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    Right with management owning less than 3%? Why would they sell? See their salaries per latest proxy. They have plow...

  • DBMD

    How cancer and obesity are related, and also a lot of the cancer therapy mechanisms in our bio portfolio like adiponecti...

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    Re ZFGN The upgrade today was from JMP Securities in San Francisco and if you go to their website you can read the analy...

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    Myron, the ALA omega-3 from land-based plants such as flax is the wrong omega-3. It is not comparable, effect-wise, to E...

  • SoGiAm

    Children genetically predisposed to both #obesity and response to fast food ads http://www.pnas.org/content/early/2016/1...

  • Dr. KSS MD PhD

    I commend insurers for not covering this asinine agent. This entire culture needs a cold dead reckoning with reality as ...

  • SoGiAm

    #OBESITY - Obesity / Weight Loss / Fitness Biology / Biochemistry Diabetes - Could turning white fat to brown hold key ...

  • SoGiAm

    From 2014! .... ETRM EnteroMedics up 20% this morning on AdCom recommendation: EnteroMedics Announces FDA Advisory Com...

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    Could someone tell me how to copy a shortcut to a previous post? I use to be able to do easily. It has changed. Thank yo...

  • arch1

    Kenny eyedoc and Oppo, I cannot argue with your logic as I cannot see a clear way to market with present management and ...

  • Steve M

    Dr. KSS; Does the promise of silencing galectin-3 obliterate the prospects of $ZFGN for obesity and $GNFTF for NASH? ...

  • Dr. KSS MD PhD

    I suspect we're about to see the biotech industry mount an all-out attack on galectin-3 because silencing it or knockdow...

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    Dr. KSS the only strange thing is that they claim to have spent on a cumlative basis $123.7 million on the "library of c...

  • SoGiAm

    Obesity plan is a failure Main content http://heartresearch.org.uk/latest-news/obesity-plan-failure We have strongly...

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    Telco I would say it differently—they have substantial capital requirements. If bremelanotide is worth a billion th...

  • SoGiAm

    #Infections, not #antibiotics, my be tied to childhood obesity, new analysis suggests http://www.nytimes.com/2016/11/01/...

  • SoGiAm

    Dr Atanas G Atanasov ‏@_atanas_ Anti-obesogenic and antidiabetic effects of plants and mushrooms https://www.researc...

  • SoGiAm

    #Obesity increases risk for 13 types of #cancer http://nyti.ms/2bjxaEr ; #Exercise can help! #WorldObesityDay #BreastCa...

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    Prometics $PLI.TO $3.10 PROMETIC’S PBI-4050 SIGNIFICANTLY REDUCES LIVER FIBROSIS IN PATIENTS WITH ALSTRÖM SYNDROME...

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    A wonderful review of #microbiome just published in Nature: *Signals from the gut microbiota to distant organs in phy...

  • SoGiAm

    $ZFGN tiny option position - I notice FEW members are following the rules and guidelines established by the author that ...

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    If it really solves obesity, if it really results in weight loss, the people who want it will do just about anything....

  • JohnM

    ZFGN NO POSITION "ZGN-1061 is a second-generation, differentiated MetAP2 inhibitor in development for severe and c...

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    $ZFGN...thanks, linling88. No position. Because they fired so many employees I thought there was no hope. Would lik...

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    Your opinions are respected and of great value here linling, and I certainly pay close attention to what you post. I agr...

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