Topic Archives: sepsis

Quickster: T2 Biosystems ($TTOO)

[Dr. KSS writes about medicine and biotech stocks for the Irregulars. He has agreed to our trading restrictions, chooses his own topics, and his words and opinions are his own. Visit his Stock Gumshoe page to see his biography, latest comments and past articles.] About 18 months ago, I came across tiny Boston-area diagnostics start-up […]

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  • Avatar

    Thanks, jk. I'll add that KSS's monthly marathon phone conferences were incredible and clearly a work of passion. Knowin...

  • SoGiAm

    Critical Pressure (pvt) - http://www.critical-pressure.com/technology.html I can't tell you how many times over the yea...

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    $ACOR np "Fatal sepsis attacks mar Acorda’s PhIII, triggering new safety measures and a pause on enrollment" https...

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    $TTOO - Interesting information from Seeking Alpha's transcript of the 11/2/17 conference call of the company's quarterl...

  • Dr. KSS MD PhD

    As I've set out gently to make clear to readers in recent weeks, let me iterate that right now, my enthusiasm for $AKAO ...

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    $TTOO Clinicians Discuss Positive Impact of T2MR Platform on Sepsis Care at IDWeek 2017 http://investors.t2biosystems....

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    $CWBR $Mitochondria $Sepsis and MOF The role of mitochondrial dysfunction in sepsis- induced multi-organ ...

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    TTOO going ballistic today and may be on its way to fulfill its great potential with its much needed test for sepsis. F...

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    $TTOO. Market seems to like this latest product. From a related article, 'Sepsis affects more than 1.6 million pat...

  • Dr. KSS MD PhD

    Ja....Viscountess Helen skewers again! So few people, even IN the industry, really GET the antibiotics space. Cubist was...

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    $TTOO smanuelm: You asked in a prior post as to what I am eyeing. My most recent purchase was on 8/8/17 for a full po...

  • Dr. KSS MD PhD

    Nobody's in trouble. I would just ask readers see this from an editorial perspective, which is that from the first menti...

  • Dr. KSS MD PhD

    As promised some deliberations on the $AKAO vs $MDCO situation. As most readers probably know, $MDCO took the wind ou...

  • JohnM

    3/26/17 clipssu Good morning Doc~ and Gummies while this isn’t BIO investing related I was fascinated by this. $N...

  • arch1

    Inflammatix [Stanford UC spinoff] has a new blood test that finds sepsis by detecting immune response factors,,, far fas...

  • SoGiAm

    $TTOO - other post in moderation. May want to review --> Quickster: T2 Biosystems ($TTOO) https://www.stockgumshoe....

  • SoGiAm

    TTOO - T2 Biosystems to Host Symposium at 27th European Congress of Clinical Microbiology and Infectious Diseases Speak...

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    Good morning Doc~ and Gummies while this isn't BIO investing related I was fascinated by this. $NoTicker but this is...

  • arch1

    Komodo dragons can bite a water buffalo and if saliva enters the bloodstream the buffola will soon die because of the mi...

  • Dr. KSS MD PhD

    Effect size: how washing hands prevented death from childbirth related sepsis in 19th century Vienna, as quantified by I...

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    The TTOO conf call message was "trust us", and the market said "ok" .. +/- unchanged today following yesterday's confcal...

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    $AKAO long Great post, Helen. Thank you. I might amplify here that when a sick patient with low temperature, tachy...

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    $AKAO: The only drug with a realistic chance of early FDA approval would be Achaogen's plazomicin. In all likelihood guv...

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    Thanks for the link. There are a lot of previous study results to look at as I don't remember the specific toxicity deta...

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    Great news about T2 Biosystems collaborating with Allergen. thanks Ben! Here are the main points from their announce...

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    $TTOO - T2 Biosystems announces five poster presentations at IDWeek 2016 - Annual Meeting of Infectious Diseases Soc...

  • Dr. KSS MD PhD

    As I see it, things look dandy for ScyNexis here. Sorry not to have replied earlier in the day. Congratulations all long...

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    Competition for $TTOO at some point in the future? Hope not. “A European scientific collaboration headed by scienti...

  • arch1

    I think this is important for all to see; pbrophyAugust 26, 2016 11:39 pm I was hoping to see more discussion in thi...

  • Dr. KSS MD PhD

    Hi Peter: Thanks for your post and readership. You might actually consider reposting your item over on the present threa...

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    I was hoping to see more discussion in this thread on TTOO specifically. Dr. KSS, I spoke with a doctor recently that c...

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    $TTOO (long) – I was investigating Sepsis Awareness month (September), 13Sep is world sepsis day, and 15Sep is the Sep...

  • arch1

    (c) I remember reading that in the time of non-existent sanitation and before anesthetics, people would beg for "cutt...

  • SoGiAm

    $SCYX longer - Also news this a.m. on CBS sepsis. Long ZKSS and Gummune. :-) Best2ALL ~ Ben...

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    $TTOO (long): Sepsis in the news today (NPR, Sepsis Alliance survey, Consumer Reports). Early detection is a recurring...

  • SoGiAm

    $TTOO related np yet - Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival ht...

  • SoGiAm

    $SCYX, crazy in share price, but with a desperately needed new antifungal.... .Fungal sepsis is always a serious, poten...

  • SoGiAm

    Found 7/27/16 in Da Man SS I am confident that in the models now being tested/trialled (ie, invasive fungemia, fungal se...

  • Dr. KSS MD PhD

    Answer to the QOD, regarding risk factors for fungal sepsis. Most people were correct in recognizing that chronic kidney...

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    I would guess (3) because I thought heavy Iv antiobiotics is the treatment for sepsis. 1) increases exposure, 2) limits ...

  • arch1

    Dr KSS Long term iv drug abusers,heroin, meth etc, seem to go for years without becoming septic. Fungus is ubiquitous, ...

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    We know (1) and (4) are risk factors. I am a bit confused about (3) - not sure why persistent antibiotic use would trigg...

  • Dr. KSS MD PhD

    Question of the Day 11 August 2016 In recent weeks, we've served up two long ideas related to the clinical fungal dis...

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    In reading about TTOO there was much made of potential savings for hospitals if sepsis was diagnosed early. Now I'm r...

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    Would disruptive TTOO tech adversely affect the likes of SCYX by reducing the need to use new branded antifungals when a...

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    The fact that I was lucky when my pneumonia-induced sepsis was caught very early actually heightens my enthusiasm for a ...

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    Looks like the FDA has only approved them for candida sepsis at this point. In fact, the major reason the stock tanke...

  • DBMD

    Thanks Glenn and Dr KSS. This technology should be able to screen for CA as well. In regards to the sepsis panel is it g...

  • arch1

    Primum non nocere. As sepsis often comes from hospital treatment it seems that anything that makes the person whole is...

  • drbonz

    Fascinating. Does this device diagnose only Candida sepsis or does it currently diagnose even bacterial sepsis?...

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    Thanks for another great article. I really appreciate the simple definition of sepsis, which makes this product much eas...

  • Dr. KSS MD PhD

    Flattery will get you everywhere (kidding). Welcome to the Gummune if you're new. The 078 side effects seen were AE's, n...

  • Dr. KSS MD PhD

    Quick comment: in at $TTOO. Glenn and I have tracked this company for 2 years and per an early am discussion feel the se...

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    Thanks, Doc! For what it's worth: My question about the precipitous drop in SCYX's PPS was the first I ever posted here...

  • Dr. KSS MD PhD

    Azole resistance is indeed a huge problem, and they're not excellent drugs. If you have fungal sepsis, would you prefer ...

  • Dr. KSS MD PhD

    Hello Tony: the answer to your question is a little complicated, and something I had to dig into to gage sentiment among...

  • Dr. KSS MD PhD

    CD-101, Cidara's echinocandin, is not available in oral form. The oral route is a great advantage for ScyNexis because i...

  • Dr. KSS MD PhD

    Fluconazole may remain first-line for vulvovaginal candidiasis, and SCY-078 become second line---still a large market. A...

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    Thnx a lot, Doc... GREAT comprehensive article!!! It would be interesting to note the percentage of sepsis mortality c...

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    While not exactly the same situation, I would also be concerned about the decrease in specialists who exercise hospital ...

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    $CCXI Reading thru the full data set its obvious; CCX168 is a stellar drug. I beats standard of care on every measure...

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    $FARN Went long $FARN this morning. The thing about Faron Pharmaceuticals and Traumakine for ARDS is this: you...

  • Dr. KSS MD PhD

    Astrolabe: I've looked over the Leading materials....interesting stuff they are doing. Some notes: (1) the current p...

  • Dr. KSS MD PhD

    Hi geoff: I started to mention as sweetener material that I think their Lpxc antibody for Pseudomonas aeruginosa could g...

  • Dr. KSS MD PhD

    Hi geoff: I started to mention as sweetener material that I think their Lpxc antibody for Pseudomonas aeruginosa could g...

  • arch1

    Some new info on blood filtration to remove sepsis induced cytokines to prevent organ failure; http://news.mit.edu/2016...

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    Im gonna go out on a limb here and bring a rabbit out of the hat. The rabbit is called called Faron Pharmaceuticals. I...

  • Dr. KSS MD PhD

    $AKAO announced earlier this week its initiation of cohort 2 in the phase 3 CARE trial. Recall that cohort 1 is the m...

  • Gui_

    Shapeshifter: Candida Albicans Fungus Fungi in the mucus of patients with cystic fibrosis has been examined by resea...

  • Dr. KSS MD PhD

    Good question. I think the answer lies in how much PCSK9i is wicked up by the monoclonals now in use. But in general, a ...

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    $TTOO New Sepsis Detector Shrinks the Diagnosis from Days to Hours Sepsis affects more than a million people every y...

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    T2 Biosystems (NASDAQ:TTOO) today reported operating highlights and financial results for the third quarter ended Septem...

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    I'm a fairly new investor in biotech stocks and must say following along with all of you who contribute to this thread h...

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    Dr. KSS, I had emailed an inquiry via the Lyn link regarding a Canadian medical device company Spectral Medical [TSX:ED...

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    $KPTI $KITE From PropThink: A rumor began to circulate late this week that one patient had died after receiving Kite...

  • Dr. KSS, MD PhD

    Let's see what they say Monday on conf. call. The trial is in diffuse large B cell lymphoma, and mostly these are frail ...

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    They should check cystoscopes too. Hospital acquired MRSA infection lead to sepsis lucky to be here....

  • Dr. KSS, MD PhD

    Frank: personally I would hold but not add. I don't think the drug is kaput, but we need more data from them. I think I ...

  • Dr. KSS, MD PhD

    I, too, am pretty worried. I hedge on throwing in the towel here for the main reason that when adversity strikes like th...

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    This is quite concerning. Need to assess and determine if there is a credible long-term safety issue with this drug. By ...

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    Short $KPTI Puts: Shares of Karyopharm Therapeutics fell to their lowest point since December 2013 this morning after...

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    $TGXSF Tigenix – a Brussels based Biotech. They have a Phase III trial for Cx601 an adipose-derived allogeneic stem...

  • Avatar

    $TGXSF Tigenix - a Brussels based Biotech. They have a Phase III trial for Cx601 an adipose-derived allogeneic stem c...

  • DBMD

    Summary of an article from American Thoracic Society meeting: "Sepsis is an infection of the bloodstream that can lead...

  • Dr. KSS, MD PhD

    As regards ASCO and $TGTX, the abstracts Glenn posted last night definitely advance the cause. The main thing of relevan...

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    Dr Kss, have been tracking this company for awhile T2 Biosystems (TTOO) and it might be time to look at them at a buy.Th...

  • Dr. KSS, MD PhD

    My congratulations go to Alder Bio this am for good data in its phase 2b trial of an anti-interleukin-6 monoclonal calle...

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    re CART-T: Glenn, this article has both good and potential bad news. At the end it mentions "Mesothelin is also found ...

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    According to Doc... Achaogen’s pivotal phase 3 trial of plazomicin versus colistin for CRE sepsis is open label. This...

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    Sharon, the PR blackeye are all the patients who died from GI scope related CRE sepsis at UCLA in the absence of an FDA ...

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    I didn't like that either, but they are speaking to stockholders not a convention of internists. My understanding is tha...

  • Dr. KSS, MD PhD

    I agree with Joe Schelble's sentiment about $AKAO. This company will not go to market with plazomicin as Achaogen. Let m...

  • Dr. KSS, MD PhD

    Peter: I think in truth there is nothing crueler in medicine than taking away all hope. Even among my dying, I will not ...

  • Dr. KSS, MD PhD

    Sharon: I think there will be some waiting on $AKAO. Great company, great drug, but as of yet, we have not gotten an enr...

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    More about CERS : Scottrade’s company background: “Cerus Corporation is a biomedical products company focus...

  • Dr. KSS, MD PhD

    Hi Matt..I am presuming you mean $REGN? ($RGEN is Repligen). I can see no real reason not to enthuse about it, though I ...

  • Dr. KSS, MD PhD

    I agree, danger, that it has ick to it. In fact, I suspect they will get serious blowback about having done this from t...

  • analog68

    Doc, months ago you touched on sepsis. Hospital acquired infection rates are 750K a year and 75K die as of 2011 data in...

  • Dr. KSS, MD PhD

    Caveat: I have biases about ATNM that may impair my objectivity, but Glenn is right. Why does AML kill? Because often...

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