This edition of the epistles of Doc Gumshoe won’t be entirely about Alzheimer’s, but there are Alzheimer’s-related news items that jump to the top, based on timeliness, if nothing more. When Doc Gumshoe last wrote about what was happening on the Alzheimer’s front, a big chunk of the piece was the FDA’s surprising – and […]
Articles
This article was originally published back in August, 2019 when we were getting lots of questions about Chris Wood’s teaser pitch — the ad is still largely the same, most of the hints and projections are identical and he still expects that February 2020 approval will send the stock soaring (yes, we’re still getting this […]
The answer to that foolish question is certainly going to be “both.” But the finger pointing at the guilty party has wobbled around a good deal in the past few years, and just before Christmas, the American Heart Association came out with a set of dietary recommendations once again apparently putting at least some blame […]
[ed. note: Michael Jorrin, who I like to call Doc Gumshoe, is a longtime medical writer (not a doctor) who writes about non-financial health and medical issues for us a couple times a month (past submissions can be found on his author page here). Like all of our authors, he chooses his own topics and […]
[Michael Jorrin, who I call “Doc Gumshoe,” is a longtime medical writer who writes on health and medicine topics for us from time to time. He is not a doctor, and his commentary is not investment-focused. He chooses his own topics, and, as with all our guest columnists, the words and opinions are his alone […]
[ed note: Michael Jorrin, who we like to call “Doc Gumshoe”, is a longtime medical writer (not a doctor) who writes non-investment articles about medicine and health topics for us once or twice a month. As with all of our guest contributors and columnists, he chooses his own topics and his words are his alone] […]
A Non-Statin Pill That Really Lowers Cholesterol, Blood Pressure and Inflammation without Side Effects Would be a Good Investment, Right?[Ed. Note: Dr. KSS writes about medical topics and biotech stocks for the Irregulars. He has agreed to our trading restrictions, and his thoughts and words are his own. Enjoy!] Any discussion of cholesterol immediately turns Brobdingnagian, such are the extremes in question. Statins, which lower LDL cholesterol, are bombastically the best-selling drugs of all […]
[ed. note: We feature the writings of Doc Gumshoe, our favorite medical scribe, every few weeks here at Stock Gumshoe. He is not a doctor, but we value his insight, research, contrariness and skepticism … and, most importantly, his ability to explain complex health issues for our readers. You can see all of Michael’s previous […]
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Another great article Doc. Very educational and helpful. Regarding polypills and other attempts to reduce cardiovascul...
Doctors who prescribe statins will tell you it is to "balance" your high and low cholesterol. It need not be high chole...
I feel compelled to add to Dr. KSS's post. I am a retired physician who was treated on and off with statins for high cho...
Thanks to Doc Gumshoe for another valuable, informative post. One point that bears repeating is the effects of statins ...
Well, if you're sticking to the biased data that predominates medical research, then the benefit of statins is only marg...
I think that is part of that the numbers show without a doubt that statins have helped and asking whom it has helped mor...
Answers to comments: To the tribe member who said it was not a “one-size-fits-all” guideline – precisely my point...
I was on statins, mostly maximum dosage for nearly 20 years when my Left Anterior Descending artery (the "widow maker") ...
Doc, Most US Dr.s still recommend statins for patients whose cholesterol exceeds guidelines even if they have had not ...
Statins are dangerous, and often come with many side effects that are worse than the problem they are trying to correct!...
Its all about the money. Re: Original Jupiter Study- In the statin group, there were 141 major cardiovascular events v...
The statins have significant side effects especially in the elderly. I stopped taking Lipitor at age 90. Since then,now...
Bempedoic acid is a significant advance. Why? Because it can be used in patients who can't tolerate statins because of m...
I'll pass. Cholesterol is not the enemy people believe it to be, and the evidence supporting the use of Statins or any c...
Esperion has worked hard to get bempedoic acid & the ezetimibe-bempedoic combo to the point where the FDA green light is...
There are many studies that seem to indicate that persons taking statin drugs appear to have statistically fewer adverse...
I'm 88. My blood pressure measures in the range of 120/65 +/- 5; pulse usually around 60 except mornings ~55. Not diabet...
Vascepa has been tested in conjunction with statins. I think they'd need to do new studies to show its effectiveness alo...
I have no faith in the use of statins in treating cholesterol and many physicians feel the same way. There has always be...
What about the long-term effects of taking statins? If you increase your life span by (say) 10%, by taking statins but ...
Great article Doc! One might think JAMA would be more thorough in vetting 'studies' such as these. Any thoughts on Vas...
The closest thing to a cure is a diet consisting solely of whole plant foods, devoid of all animal products. Since the v...
Another "cover-up" of natural cures? After sitting through most of their video presentation, I opted for their book and ...
$ESPR small position > Esperion Announces Late-Breaking Oral Presentation of Final Results of Phase 3 Long-Term Safety S...
All the plaque and the problems they cause didn't have any effect on my two grandmothers who were born in the late 1890'...
Why does big pharma not look at HDL? Because Statins do not.affect them....
My family typically lives into their 90's (previous 2 generations / both sides). I have high cholesterol, assume they di...
I too agree with these comments. I was put on statins etc. and scheduled for a high-priority triple bypass 18 years ago...
I agree with you 100%. Forty five years ago I was diagnosed with high cholesterol (300 Total) and was put on statins th...
STM, I claim no expertise. I couldn't use statins. I think $ESPR has an important niche. I don't believe that the man...
Author: Roger I guess whether statins provide longevity remains an issue. I had muscle deterioration and problems with...
Lannas, at this moment, you're right. I didn't sell $ESPR. I guess whether statins provide longevity remains in issue....
$ESPR ow Overreaction, price has already moved back up. The value of ESPR is to take place of statins not as add on, IM...
$ESPR, long:- Some thoughts about $ESPR versus "MDCO's inclisiran" as as stated by Citicorp in Pascal's post: In the ...
$ESPR Roger appreciate your comments. And cheers! to 88! Here’s to many more! I too have struggled with muscle p...
Also if you research further you will find that us older people actually need a higher blood pressure to get the require...
$ESPR? "EXPR – if you are in it, stay for the duration of Phase 3. The drug will replace statins – a huge market....
CAPR - he is staying long. It's an exosome play with good Phase 2 data. Will be golden if current trial works. ONCS -...
$ESPR LONG Esperion Therapeutics (ESPR 60.66) target raised to $75 from $20 at Chardan Capital Markets. Firm notes ...
$CWBR $Mitochondria $heart diseases A newly published report by Johns Hopkins researchers, again, pointed to a Mi...
Welcome to the Gummune Fred & thank you for posting your statins experiences! Long #ZKSS, GREAT Gummune & $ESPR...
Indeed, the risk of becoming type II diabetic from statins is high....unacceptably so. Equally unacceptable is the MD pu...
Two friends that were on statins that became diabetic, a side effect. If he has been on MetFormin for 15 years and takin...
$CWBR Good question for Doc. Will you have a Mitochondria of a ten year old? Did you need statins at ten? Will I once a...
Long CWBR Does CWBR displace statins and ESPR's solution to lipidemia?...
I am one month short of 88. Quit using statins a few years ago after bad side effects and am using old E Indian medicin...
Statins can result in lower body levels of CoQ10,BUT there is no evidence yet that this is clinically meaningful. It may...
$statins, CoQ-10, heart If my memory serves me right, Dr. KSS or someone here once said that taking statins can reduc...
FING-B np - First product launch with Fingerprints' touch sensor FPC1028 http://hugin.info/132202/R/2136498/817619.pdf ...
$ESPR (of high relevance) NEJM EDITORIAL "Targeting Inflammation in Coronary Artery Disease" Robert A. Harrington, ...
$NVS - Was surprised I was the first to post about this, but double-checked and saw the above link from rfyjr. I add...
$Statins $ESPR (marketing relevance) - A new study nullified statins' advantage in cancer patients "Examining Bias i...
$ESPR - The trial results here are so good at every checkpoint, it seems criminal for the FDA not to issue some sort of ...
Absolutamente, reina mia! That alirocumab price is deeply discounted, and remember: the PSCK9i's have been SO successful...
it would be fascinating to do a kind of isobolographic waterfall curve here---not trying to confuse people, but for a fi...
Author: hedy1234 Comment: $STATINS COQ-10 can help with statin symptoms. ------------------------- Author: Dr. KS...
OK, let's do some critical thinking here. The study on which this all is based appeared in Annals of Internal Medicine h...
Yes, true, it can, especially in ubiquinol form, not ubiquinone. But two caveats: first, no large clinical trial has eve...
$STATINS COQ-10 can help with statin symptoms....
$WSJ article on stopping statins. Thanks for posting. Not sure if father-in-law ever complained of muscle aches, but aft...
jcasteleyn Don't have a WSJ subscription. Father-in-law fell and broke his hip, has off and on dementia-like symptoms (f...
Eyedoc is right. I had a tempestuous dream last night that somehow I was being seen by a physician semi-against my wishe...
Rick, thanks for posting this article. I am astonished that recurrent adverse reactions are this low. I believe that $ES...
$ESPR Here is a summary and opinion from the NEJM journal watch: MEDICAL NEWS | PHYSICIAN'S FIRST WATCH July 25, ...
Hi Dr. KSS. I'd like to add my experiences with Metf0rmin. I've been taking metformin since 2007 at the urging of my ph...
My perennial grievance with statins is that they intensify insulin resistance in both genders, albeit it to a greater de...
And one more from biopharma drive: "This could either be due to lower than expected efficacy, adverse events seen in ...
$MRK Thanks for your comments on the hottest biotech news today. If I understand correctly Doc, to promote anacetrapib, ...
Esperion shares may sputter this morning on new from $MRK that anacetrapib met primary study goals in a CVOT. I hope rea...
12/7/14 Dr. KSS, MD PhD, author of this article, says: December 7, 2014 at 6:58 pm Well, all the statins cause loss...
$ESPR long. Hey Doc - in today's WSJ, "When Cholesterol Drugs Cost $14,000, an Insurance Tug-of-War" Sumathi Reddy write...
Which reminds me: at the last conference call, I did make an error. I alluded to $ESPR having a market cap of $3B, and t...
Do some research on statins and you may find you can save your money on those also. I have and I refuse to take them fro...
I saw no mention of the need to take large doses of C0Q-10 when choosing to take statins. Statins are known to reduce l...
Hi Phil: $RDUS was one Glenn and I worked up together years ago and I felt it would go the distance. I blinked about get...
Dear Doc G -- Thank you for the thoughtful response. I did not mean to imply that you have never differentiated between...
For a discussion of the difference between absolute and relative risk, may I refer you to the Doc Gumshoe piece from 201...
Stock Gumshoe has demonstrated that he has the analytical and investigative skills to uncover marketing scams by individ...
$ABVX and others from LaBiotech - 10 Hot European Biotechs to Observe in 2017 http://labiotech.eu/10-hot-biotechs-europ...
$ESPR - new study results should bode well for Esperion "Statins Increase Diabetes Risk by up to 50% in Older Women" ...
$ESPR Interesting Article: http://blogs.sciencemag.org/pipeline/archives/2017/03/20/what-pcsk9-is-telling-us-about-drug...
$ESPR -Waiting for Dr KSS to weigh in may not be wise. As recently as March 4th, he restated his views which have been ...
$ESPR's annual shareholder meeting will be live and online 17 April 2017 at 8 am. Would be good if 2-3 of this group ...
I nominate that for post of the year! Re genes, a dear friend had very high cholesterol levels from the time when ...
$ESPR long long and increasing position - Thank you Doc for an amazing answer. Your knowledge is deep and you are such a...
This is for mtpoulsen and her query earlier today about $ESPR. I am glad she asked because we've needed to put it, af...
$ESPR long 1/2 position Esperion is up 57% since I established the position early February and the only catalyst I can ...
Allison and GUI, in addition to stock-specific links, there are links to 5 comments about statins on the "KSS Wisdom" ...
Sorry to hear about your stroke, Gui. I see that Dr Kss has given you some advice on use of statins. I know that you wil...
Thank you so much sir, that it is just the advice I was looking for from you whom I trust, I constantly fall into the tr...
A key thing is that women are about a third more likely than men to be tipped into DM-II by statins. This may owe to gen...
I am really sorry to hear you've experienced a stroke; I had definitely noticed your absence. I have to say that in this...
Hello Tia - I'm not sure there IS a single discussion on statins specifically as they're old school and the stocks in wh...
OT: Hello all, I haven't posted or read in some time, but could someone direct me to our discussion on statins? I'm a bi...
Those comments are very helpful, Frank, thank you. Medscape says that" Lipophilic statins cross the blood-brain barrie...
Thanks, Frank. When I heard Dr Toga talk about lipophilic statins, I just Googled it. It gave me a list of them....
Taking statins that are lipohilic, over a long term , leads to smaller hippocampi in females.... is how I would take the...
$ESPR (np) Adadfarm: Chronic means "persisting for a long time or constantly recurring." Doctors use chronic fo...
I find the terminology "taking chronic lipophiic statins" extremely confusing; please explain further. How can a statin...