Topic Archives: statins

[ed. note: Michael Jorrin, who I like to call Doc Gumshoe, is a longtime medical writer (not a doctor) who writes about non-financial health and medical issues for us a couple times a month (past submissions can be found on his author page here). Like all of our authors, he chooses his own topics and […]

[Ed. Note: Dr. KSS writes about medical topics and biotech stocks for the Irregulars. He has agreed to our trading restrictions, and his thoughts and words are his own. Enjoy!] Any discussion of cholesterol immediately turns Brobdingnagian, such are the extremes in question. Statins, which lower LDL cholesterol, are bombastically the best-selling drugs of all […]

Comments

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    Doctors who prescribe statins will tell you it is to "balance" your high and low cholesterol. It need not be high chole...

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    I feel compelled to add to Dr. KSS's post. I am a retired physician who was treated on and off with statins for high cho...

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    Thanks to Doc Gumshoe for another valuable, informative post. One point that bears repeating is the effects of statins ...

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    Well, if you're sticking to the biased data that predominates medical research, then the benefit of statins is only marg...

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    I think that is part of that the numbers show without a doubt that statins have helped and asking whom it has helped mor...

  • Michael Jorrin, "Doc Gumshoe"

    Answers to comments: To the tribe member who said it was not a “one-size-fits-all” guideline – precisely my point...

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    I was on statins, mostly maximum dosage for nearly 20 years when my Left Anterior Descending artery (the "widow maker") ...

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    Doc, Most US Dr.s still recommend statins for patients whose cholesterol exceeds guidelines even if they have had not ...

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    Statins are dangerous, and often come with many side effects that are worse than the problem they are trying to correct!...

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    Its all about the money. Re: Original Jupiter Study- In the statin group, there were 141 major cardiovascular events v...

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    The statins have significant side effects especially in the elderly. I stopped taking Lipitor at age 90. Since then,now...

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    Bempedoic acid is a significant advance. Why? Because it can be used in patients who can't tolerate statins because of m...

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    I'll pass. Cholesterol is not the enemy people believe it to be, and the evidence supporting the use of Statins or any c...

  • Michael Jorrin, "Doc Gumshoe"

    Esperion has worked hard to get bempedoic acid & the ezetimibe-bempedoic combo to the point where the FDA green light is...

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    There are many studies that seem to indicate that persons taking statin drugs appear to have statistically fewer adverse...

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    I'm 88. My blood pressure measures in the range of 120/65 +/- 5; pulse usually around 60 except mornings ~55. Not diabet...

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    Vascepa has been tested in conjunction with statins. I think they'd need to do new studies to show its effectiveness alo...

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    I have no faith in the use of statins in treating cholesterol and many physicians feel the same way. There has always be...

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    What about the long-term effects of taking statins? If you increase your life span by (say) 10%, by taking statins but ...

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    Great article Doc! One might think JAMA would be more thorough in vetting 'studies' such as these. Any thoughts on Vas...

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    The closest thing to a cure is a diet consisting solely of whole plant foods, devoid of all animal products. Since the v...

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    Another "cover-up" of natural cures? After sitting through most of their video presentation, I opted for their book and ...

  • SoGiAm

    $ESPR small position > Esperion Announces Late-Breaking Oral Presentation of Final Results of Phase 3 Long-Term Safety S...

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    All the plaque and the problems they cause didn't have any effect on my two grandmothers who were born in the late 1890'...

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    Why does big pharma not look at HDL? Because Statins do not.affect them....

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    My family typically lives into their 90's (previous 2 generations / both sides). I have high cholesterol, assume they di...

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    I too agree with these comments. I was put on statins etc. and scheduled for a high-priority triple bypass 18 years ago...

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    I agree with you 100%. Forty five years ago I was diagnosed with high cholesterol (300 Total) and was put on statins th...

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    STM, I claim no expertise. I couldn't use statins. I think $ESPR has an important niche. I don't believe that the man...

  • JohnM

    Author: Roger I guess whether statins provide longevity remains an issue. I had muscle deterioration and problems with...

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    Lannas, at this moment, you're right. I didn't sell $ESPR. I guess whether statins provide longevity remains in issue....

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    $ESPR ow Overreaction, price has already moved back up. The value of ESPR is to take place of statins not as add on, IM...

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    $ESPR, long:- Some thoughts about $ESPR versus "MDCO's inclisiran" as as stated by Citicorp in Pascal's post: In the ...

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    $ESPR Roger appreciate your comments. And cheers! to 88! Here’s to many more! I too have struggled with muscle p...

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    Also if you research further you will find that us older people actually need a higher blood pressure to get the require...

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    $ESPR? "EXPR – if you are in it, stay for the duration of Phase 3. The drug will replace statins – a huge market....

  • JohnM

    CAPR - he is staying long. It's an exosome play with good Phase 2 data. Will be golden if current trial works. ONCS -...

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    $ESPR LONG Esperion Therapeutics (ESPR 60.66) target raised to $75 from $20 at Chardan Capital Markets. Firm notes ...

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    $CWBR $Mitochondria $heart diseases A newly published report by Johns Hopkins researchers, again, pointed to a Mi...

  • SoGiAm

    Welcome to the Gummune Fred & thank you for posting your statins experiences! Long #ZKSS, GREAT Gummune & $ESPR...

  • DrKSSMDPhD

    Indeed, the risk of becoming type II diabetic from statins is high....unacceptably so. Equally unacceptable is the MD pu...

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    Two friends that were on statins that became diabetic, a side effect. If he has been on MetFormin for 15 years and takin...

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    $CWBR Good question for Doc. Will you have a Mitochondria of a ten year old? Did you need statins at ten? Will I once a...

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    Long CWBR Does CWBR displace statins and ESPR's solution to lipidemia?...

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    I am one month short of 88. Quit using statins a few years ago after bad side effects and am using old E Indian medicin...

  • DrKSSMDPhD

    Statins can result in lower body levels of CoQ10,BUT there is no evidence yet that this is clinically meaningful. It may...

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    $statins, CoQ-10, heart If my memory serves me right, Dr. KSS or someone here once said that taking statins can reduc...

  • SoGiAm

    FING-B np - First product launch with Fingerprints' touch sensor FPC1028 http://hugin.info/132202/R/2136498/817619.pdf ...

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    $ESPR (of high relevance) NEJM EDITORIAL "Targeting Inflammation in Coronary Artery Disease" Robert A. Harrington, ...

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    $NVS - Was surprised I was the first to post about this, but double-checked and saw the above link from rfyjr. I add...

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    $Statins $ESPR (marketing relevance) - A new study nullified statins' advantage in cancer patients "Examining Bias i...

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    $ESPR - The trial results here are so good at every checkpoint, it seems criminal for the FDA not to issue some sort of ...

  • DrKSSMDPhD

    Absolutamente, reina mia! That alirocumab price is deeply discounted, and remember: the PSCK9i's have been SO successful...

  • DrKSSMDPhD

    it would be fascinating to do a kind of isobolographic waterfall curve here---not trying to confuse people, but for a fi...

  • JohnM

    Author: hedy1234 Comment: $STATINS COQ-10 can help with statin symptoms. ------------------------- Author: Dr. KS...

  • DrKSSMDPhD

    OK, let's do some critical thinking here. The study on which this all is based appeared in Annals of Internal Medicine h...

  • DrKSSMDPhD

    Yes, true, it can, especially in ubiquinol form, not ubiquinone. But two caveats: first, no large clinical trial has eve...

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    $STATINS COQ-10 can help with statin symptoms....

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    $WSJ article on stopping statins. Thanks for posting. Not sure if father-in-law ever complained of muscle aches, but aft...

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    jcasteleyn Don't have a WSJ subscription. Father-in-law fell and broke his hip, has off and on dementia-like symptoms (f...

  • DrKSSMDPhD

    Eyedoc is right. I had a tempestuous dream last night that somehow I was being seen by a physician semi-against my wishe...

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    Rick, thanks for posting this article. I am astonished that recurrent adverse reactions are this low. I believe that $ES...

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    $ESPR Here is a summary and opinion from the NEJM journal watch: MEDICAL NEWS | PHYSICIAN'S FIRST WATCH July 25, ...

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    Hi Dr. KSS. I'd like to add my experiences with Metf0rmin. I've been taking metformin since 2007 at the urging of my ph...

  • DrKSSMDPhD

    My perennial grievance with statins is that they intensify insulin resistance in both genders, albeit it to a greater de...

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    And one more from biopharma drive: "This could either be due to lower than expected efficacy, adverse events seen in ...

  • AC/DC

    $MRK Thanks for your comments on the hottest biotech news today. If I understand correctly Doc, to promote anacetrapib, ...

  • DrKSSMDPhD

    Esperion shares may sputter this morning on new from $MRK that anacetrapib met primary study goals in a CVOT. I hope rea...

  • JohnM

    12/7/14 Dr. KSS, MD PhD, author of this article, says: December 7, 2014 at 6:58 pm Well, all the statins cause loss...

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    $ESPR long. Hey Doc - in today's WSJ, "When Cholesterol Drugs Cost $14,000, an Insurance Tug-of-War" Sumathi Reddy write...

  • DrKSSMDPhD

    Which reminds me: at the last conference call, I did make an error. I alluded to $ESPR having a market cap of $3B, and t...

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    Do some research on statins and you may find you can save your money on those also. I have and I refuse to take them fro...

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    I saw no mention of the need to take large doses of C0Q-10 when choosing to take statins. Statins are known to reduce l...

  • DrKSSMDPhD

    Hi Phil: $RDUS was one Glenn and I worked up together years ago and I felt it would go the distance. I blinked about get...

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    Dear Doc G -- Thank you for the thoughtful response. I did not mean to imply that you have never differentiated between...

  • Michael Jorrin, "Doc Gumshoe"

    For a discussion of the difference between absolute and relative risk, may I refer you to the Doc Gumshoe piece from 201...

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    Stock Gumshoe has demonstrated that he has the analytical and investigative skills to uncover marketing scams by individ...

  • SoGiAm

    $ABVX and others from LaBiotech - 10 Hot European Biotechs to Observe in 2017 http://labiotech.eu/10-hot-biotechs-europ...

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    $ESPR - new study results should bode well for Esperion "Statins Increase Diabetes Risk by up to 50% in Older Women" ...

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    $ESPR Interesting Article: http://blogs.sciencemag.org/pipeline/archives/2017/03/20/what-pcsk9-is-telling-us-about-drug...

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    $ESPR -Waiting for Dr KSS to weigh in may not be wise. As recently as March 4th, he restated his views which have been ...

  • DrKSSMDPhD

    $ESPR's annual shareholder meeting will be live and online 17 April 2017 at 8 am. Would be good if 2-3 of this group ...

  • arch1

    I nominate that for post of the year! Re genes, a dear friend had very high cholesterol levels from the time when ...

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    $ESPR long long and increasing position - Thank you Doc for an amazing answer. Your knowledge is deep and you are such a...

  • DrKSSMDPhD

    This is for mtpoulsen and her query earlier today about $ESPR. I am glad she asked because we've needed to put it, af...

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    $ESPR long 1/2 position Esperion is up 57% since I established the position early February and the only catalyst I can ...

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    Allison and GUI, in addition to stock-specific links, there are links to 5 comments about statins on the "KSS Wisdom" ...

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    Sorry to hear about your stroke, Gui. I see that Dr Kss has given you some advice on use of statins. I know that you wil...

  • Gui_

    Thank you so much sir, that it is just the advice I was looking for from you whom I trust, I constantly fall into the tr...

  • DrKSSMDPhD

    A key thing is that women are about a third more likely than men to be tipped into DM-II by statins. This may owe to gen...

  • DrKSSMDPhD

    I am really sorry to hear you've experienced a stroke; I had definitely noticed your absence. I have to say that in this...

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    Hello Tia - I'm not sure there IS a single discussion on statins specifically as they're old school and the stocks in wh...

  • Gui_

    OT: Hello all, I haven't posted or read in some time, but could someone direct me to our discussion on statins? I'm a bi...

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    Those comments are very helpful, Frank, thank you. Medscape says that" Lipophilic statins cross the blood-brain barrie...

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    Thanks, Frank. When I heard Dr Toga talk about lipophilic statins, I just Googled it. It gave me a list of them....

  • arch1

    Taking statins that are lipohilic, over a long term , leads to smaller hippocampi in females.... is how I would take the...

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    $ESPR (np) Adadfarm: Chronic means "persisting for a long time or constantly recurring." Doctors use chronic fo...

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    I find the terminology "taking chronic lipophiic statins" extremely confusing; please explain further. How can a statin...

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    $ESPR long Arthur Toga, PhD, head of the brain imaging and mapping center at USC, Professor of Neurology, Ophthalmolo...

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