Topic Archives: weight loss

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    On getting older (now 65), started experiencing negative health effects (overweight, hypertension, leaky gut), and so st...

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    $ZFGN Not necessarily. I'd never thought of it before, but the original purpose of the ketogenic diet (high fat, low...

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    re: HCG (human chorionic gonadotropin) for weight loss. My wife and I first used the spray in 2010. We followed the su...

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    $Metformin $CWBR I just read this article about Metformin - https://www.medscape.com/viewarticle/877965?src=soc_f...

  • Dr. KSS MD PhD

    A current perspective on $ZFGN is that analysts mostly have left it for dead and that bona fide insider ownership (using...

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    I basically did the same thing starting last January. My A1C went from 9.2 down to 6.1 with the exact same weight loss y...

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    Thank you Doc for another excellent well reasoned and laid out article. Yes, I agree with you - I have at least one pati...

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    $OHRP np; there has been a lot of press articles over Trodusquemine (MSI-1436) in the past couple weeks, based on resear...

  • Dr. KSS MD PhD

    I have to admit my interest in $ZFGN has waned too, for reasons I've described. Its next-gen agent clearly isn't as pote...

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    $CWBR - lp Look at the weight loss numbers. Both total and % of fat loss compared to liraglutide. I hope the hotel ba...

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    $CWBR no position Do not go for Ponce De Leon narrations, they end in tears and lack of patience. Although the mice a...

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    Vitamin K2 and weight loss: https://www.ncbi.nlm.nih.gov/m/pubmed/28952607/...

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    Dr KSS, I feel kind of stuck then. I did try going off simvastatin after considerable weight loss and while exercising...

  • JohnM

    Re: $ZGNX and fenfluramine, allisondbl, Belviq is like fenfluramine without the cardiac side effects. Belviq plus phente...

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    Re: $ZGNX and fenfluramine. The withdrawal of fenfluramine REALLY irked me. Fen/phen was a magic combination. The only w...

  • Dr. KSS MD PhD

    Hi Richardo....I can't find the post by Moriarty that you are referring to, but I think that Zafgen has probably debugge...

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    $Magnesium Glycinate Demonstrating a total lack of imagination and initiative, I obtained mine from Pure Encapsulations...

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    $No Ticker Peter, may I ask you where you get this magnesium? Can you get it over the counter? There are all kinds of...

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    I took our metformin conversation to heart also. I had my annual PCP visit a few weeks after. I carried a lot of weight ...

  • Dr. KSS MD PhD

    Here's a message about potassium and carbs from my good friend nutritionist and health blogger Sheila Amir: Hey there...

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    $ZFGN Cancer-induced anorexia inspires potentially powerful antiobesity drug By Ryan CrossAug. 30, 2017 , 1:54 PM ...

  • Dr. KSS MD PhD

    thanks, Marianne....I read it via your link. Interesting how they are placing more emphasis than before on glycemic cont...

  • Dr. KSS MD PhD

    Ja, please do. I have to say honestly I DON'T think anything major is wrong. I think the universe has probably just sent...

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    And to think Kevin Trudeau got 10 years for the books he wrote exposing the FDA, Big Pharma, Weight Loss industry, etc. ...

  • Dr. KSS MD PhD

    I reached out to Zafgen $ZFGN this past week for some clarification regarding clinical trial status. Apparently a 12-...

  • arch1

    Doc Thank you for clearing that up. Any agent that would make weight loss easier or even humanly possible would be a ric...

  • Dr. KSS MD PhD

    What failure by others? People have gone great guns in this space and even Zafgen had smashing success with the weight l...

  • Dr. KSS MD PhD

    In actual fact Zafgen's agents drive lipolysis preferentially as a weight loss mechanism. They DO appear to curb the com...

  • Dr. KSS MD PhD

    Eyedoc, yes I think it's doomed. Factor D is a serine proteinase that participates only to generate factor B via the alt...

  • Dr. KSS MD PhD

    Frank: terrific of you to find this work. I have to say my skepticism here is extreme, however. Ghrelin has been in the ...

  • Dr. KSS MD PhD

    Hard to believe any publication would be lauded for having pounded the table on Dendreon and Arena, Dendreon is the most...

  • Dr. KSS MD PhD

    One comment about the new Zafgen data is this, and it's curiosity-rousing though not long-thesis-puncturing: "As prev...

  • SoGiAm

    $ZFGN - Zafgen to Present Two Late-Breaking Abstracts for ZGN-1061 at the American Diabetes Association 77th Scientific ...

  • Dr. KSS MD PhD

    Yes. There is no scientific evidence from any randomized clinical trial to suggest benefit. I can think of no biomedical...

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    A Friday question blending 2 different Gummy threads: Which would be a better way to cure America's Obesity problem? T...

  • Dr. KSS MD PhD

    Zimmie: Yes, an interesting idea. But, one other answer to your question is AbiVax's bundle of inducible NK cell activat...

  • Dr. KSS MD PhD

    Thanks breek. Welcome, and we are thrilled that you are among us. I do seriously regard Zafgen as having got it right th...

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    Zafgen, Inc. (Nasdaq:ZFGN) today announced positive topline data from its Phase 1 clinical trial of ZGN-1061, the Compan...

  • Dr. KSS MD PhD

    Thanks geoffb for a toothy post. Let me add a couple of things. First, the inventor of the D-dimer test, Chuck Greenberg...

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    ZFGN (long) The 2 main "negatives" posted on twitter are easily countered: 1) "The Phase 1 results are for only 28...

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    $ZFGN - listened to the call and came away impressed as well. There is some hubbub on twitter about this not creating we...

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    $ZFGN - FP looking to add more Those twitter specialists are picking apart the results but they are forgetting what you...

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    $ZFGN -- "That’s not the kind of sud­den and mas­sive weight loss that be­lo­ranib could trig­ger in the first ...

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    $ZFGN long - BOSTON, May 04, 2017 (GLOBE NEWSWIRE) -- Zafgen, Inc. (Nasdaq:ZFGN) today announced positive topline data f...

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    $ZFGN Long (since 30s) Zafgen, Inc. Zafgen Announces Positive Topline Phase 1 Data for ZGN-1061, a Second Generatio...

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    $NTRP np I am very sad today that the trial did not have a more robust outcome. My father died from AD and my Mom from a...

  • Dr. KSS MD PhD

    I'll add, however, that I may NOT be adding on the dips as I think there is wisdom in limiting the size of any position ...

  • Dr. KSS MD PhD

    John: as a physician I am guilty as charged in that I belong to the doctor club. We are horrible in this respect and vie...

  • JohnM

    $ZFGN $VVUS $ARNA $OREX The two problems I've seen with weight-loss drugs are: 1. The FDA and many doctors seem to th...

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    Helen[and cleveland, eyedoc, dr kss] First, thanks helen for the call education, very helpful, second, at the risk of tr...

  • Dr. KSS MD PhD

    You are right Joe. Thanks for pointing this out. Folks what he's alluding to is the glorious summer of 2015 when good mi...

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    https://www.youtube.com/watch?v=v9Aw0P7GjHE&t=3572s For what it's worth. One main take away: Fung claims that long t...

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    Weight loss is a real struggle. I was up at 250 at my wedding, got motivated. I got down to 150 lbs only to find myself...

  • Dr. KSS MD PhD

    I appreciate eyedoc's thorough synopsis of Hughes's presentation on Zafgen, in which I remain long. I will be fascinated...

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    $ZFGN long I listened to Thomas Hughes, PhD presentation at Leerink yesterday. He focused on their new compound ZGN-...

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    I think I might be one of the few people in the world who really can't stand the smell or taste of coffee... I used to u...

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    Personal interest in PLX over anti-TNF trial but for my son recently diagnosed w/severe Crohn's w/a TNF of 29. Nothing i...

  • DBMD

    summary of medical weight loss strategies http://ascopubs.org/doi/full/10.1200/JCO.2016.66.8806...

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    Re ZFGN The upgrade today was from JMP Securities in San Francisco and if you go to their website you can read the analy...

  • Dr. KSS MD PhD

    This is in follow-on to the thought question posed earlier today after Sogiam''s post about $JNJ taking on an anti-CB-1 ...

  • arch1

    Re $ZFGN Weight loss without diet and exercise? The sky is the limit to live on the fat of the land.... :)...

  • Dr. KSS MD PhD

    Thanks eliamji. Biology is totally reducible, of course, to "mere" physics and chemistry. And I agree with you....at tho...

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    Dr. KSS - Thank you very much. I've been holding on to $ZFGN and will continue to do so. I was also going to see the rel...

  • Dr. KSS MD PhD

    Someone, jokin I think, was asking yesterday about a clipping from Sciencedaily and its relevance to $ZFGN. The clipping...

  • Dr. KSS MD PhD

    Hi jokin: Smoking works its brain magic mainly by inducing dopamine release. You then feel good....quimbly all over. Tas...

  • Dr. KSS MD PhD

    A wise formulation about $ZFGN from the Thumbster. The biggest problem with Zafgen is that it never did enough backgr...

  • Dr. KSS MD PhD

    As I have presented before, the hold on beloranib is not going away. It's a terminated drug. Zafgen is developing a seco...

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    1. I watched the video on their website. I understand how they deploy and fill, but how on Earth do they deflate it. I...

  • Dr. KSS MD PhD

    I try to cover the biotech IPO market, and wonder if Obalon Therapeutics may be of interest to some people. I myself am ...

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    If it really solves obesity, if it really results in weight loss, the people who want it will do just about anything....

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    The study concluded that the effect appeared to be mediated by weight loss. The trial was conducted in China, which pres...

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    NASH: $ICPT $GILD $GNFT - Clinical trial shows moderate exercise is effective for nonalcoholic fatty liver disease, as c...

  • Dr. KSS MD PhD

    Regarding the Question of the Day for yesterday, 23 August, I was out late and postponed putting up the answers. The ...

  • Dr. KSS MD PhD

    Biotech question of the day: Obesity is among our biggest public health problems and personal frustrations. The biotechn...

  • JohnM

    $ZFGN - going to $0 causes financial pain. Leaving a loss in your portfolio (instead of maybe sharing it with the IRS) c...

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    Hi Anamorphic! Been lurking, but my investments lately have been in medicine- I turned into a kidney stone factory. Ve...

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    $RLYP New trial with patiromer, sponsored by the University of Texas Health Science Center at San Antonio. NCT0282362...

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    As far as I know, they haven't released that information--but I agree, and I wonder if there may be signs that an indivi...

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    So, manatee they may need to be switched to placebo plus maintained on whatever regimen is provided during the trial, du...

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    Hi Nuacht, As a non-scientist treating this like a giant puzzle, I guess I'd respond that we know (from results from ...

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    $ZFGN long. Is not the proposed benefit of the "on/off" treatment dependent on the patients not reversing their weight l...

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    With regard to $ZFGN: This coming from an admittedly uninformed investor without a scientific background: I am tru...

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    Doc, Since very little to no clotting has been attributed to the Obesity study could the administration of beloranib be...

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    $ZFGN, yeah, feeling a little nervous, too, because my position is largish. But when I think about the struggle of die...

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    $ZFGN (long) You'll want to look at that weight loss again... they were losing 14 to 15 kg, which was around 12-13 perc...

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    Long ZFGN. I wish is was impressed with the 2% weight loss in six months. eg, a 400# person would lose 8# compared to ...

  • Dr. KSS MD PhD

    Excellent new basic science study in new issue of Nature on neurotensin and its relationship to obesity and in particula...

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    $ZFGN Long and deep. The one thing that bothers me here is the sense of 'ownership' of the side effects, of a sort o...

  • SoGiAm

    $ZFGN ish Long - Nanoparticles Encapsulate Weight Loss Drugs to Reduce Side Effects http://www.medgadget.com/2016/05/na...

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    Here is an interesting article about the "biggest loser" participants and how they can't keep the weight off - Zafgen we...

  • Dr. KSS MD PhD

    Very engaging read over at NY TImes this am on the natural history of weight losers. http://www.nytimes.com/2016/05/0...

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    People in the United States voluntarily spend unbelievable amounts of money on weight loss programs and products. Not ev...

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    Mmmm, I do like your thinking here, Joe and Alan. I don't doubt that Zafgen could drop below cash value as this is one...

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    I sold my ESPR for just such a purchase, because ESPR has such a long way to go before news. ZFGN, on the other hand, ...

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    btl...I agree, I am not expecting a dramatic price move, although it sure would be welcome. It's more like the prospect...

  • achandra13

    $ZFGN Isn't this beautiful to read :-) "Patients with PWS had very high fat mass (approximately 50%) at baseline. Ap...

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    $ZFGN Those numbers look awesome. The PWS patients lost weight.....I thought a spectacular outcome was if they simply ...

  • JohnM

    To be approved for treating obesity, the FDA requires that a drug induces statistically significant placebo-adjusted wei...

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    $ZFGN...Speaking of which, some expert or at least informed interpretation of these results would be welcome Sunday nigh...

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